A5031104715- Colorectal Cancer Screening and Detection
- Machine Learning in Healthcare
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Text Readability and Simplification
- Pancreatitis Pathology and Treatment
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Artificial Intelligence in Healthcare and Education
- Nutritional Studies and Diet
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Topic Modeling
- Genetic factors in colorectal cancer
- Genetics, Aging, and Longevity in Model Organisms
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Biomedical Text Mining and Ontologies
Michigan State University
2023-2025
Stony Brook University
2020-2022
Mount Sinai Hospital
2022
Stony Brook University Hospital
2022
Applied Mathematics (United States)
2022
New York City Health and Hospitals Corporation
2022
The King's College
2022
SUNY Downstate Health Sciences University
2022
State University of New York
2022
Stony Brook School
2021
The emerging large language models (LLMs) are actively evaluated in various fields including healthcare. Most studies have focused on established benchmarks and standard parameters; however, the variation impact of prompt engineering fine-tuning strategies not been fully explored. This study GPT-3.5 Turbo, GPT-4, Llama-7B against BERT medical fellows' annotations identifying patients with metastatic cancer from discharge summaries. Results revealed that clear, concise prompts incorporating...
Abstract Background: Mismatch repair (MMR) status plays a critical role in colorectal cancer (CRC), influencing tumor biology and response to therapies. MMR-deficient (MMR-d) tumors, characterized by microsatellite instability (MSI), exhibit high mutation burdens increased T cell infiltration, whereas MMR-proficient (MMR-p) tumors typically demonstrate low density poor immune checkpoint inhibitor response. Despite well-documented clinical implications, the molecular cellular differences of...
Background. Fecal microbiota transplantation (FMT) is an effective treatment of recurrent Clostridioides difficile infections (rCDI), but has more limited efficacy in treating either ulcerative colitis (UC) or Crohn’s disease (CD), two major forms inflammatory bowel diseases (IBD). We hypothesize that FMT recipients with rCDI and/or IBD have baseline fecal bile acid (BA) compositions differ significantly from their healthy donors and will normalize the BA compositions. Aim. To study effect...
Pancreatic cancer is characterized by aggressive growth and resistance to treatment. Identification of unique biomarkers for diagnosis prognosis important treatment this disease. We investigated the expression patterns mucin 1 (MUC1), 2 (MUC2) cytokeratin 17 (CK17) in both normal tissues metastatic adenocarcinomas using immunohistochemistry (IHC). have shown that MUC1 (pan-epithelial membrane mucin), MUC2 (intestinal-type secretory mucin) CK17 can be used as a panel markers distinguish...
This study assesses the ability of state-of-the-art large language models (LLMs) including GPT-3.5, GPT-4, Falcon, and LLaMA 2 to identify patients with mild cognitive impairment (MCI) from discharge summaries examines instances where models' responses were misaligned their reasoning. Utilizing MIMIC-IV v2.2 database, we focused on a cohort aged 65 older, verifying MCI diagnoses against ICD codes expert evaluations. The data was partitioned into training, validation, testing sets in 7:2:1...
Impact of type 2 diabetes on adenoma detection in screening colonoscopies performed disparate populations
In the United States, individuals of Black/African Ancestry (AA) have a higher incidence and mortality from colorectal cancer (CRC) compared to White/European (EA). order develop an approach towards disentangling complex effects associated race socioeconomic factors on CRC outcome, we conducted manual chart review sporadic pathological diagnoses (total n = 334) at urban public hospital (UH) suburban university (SH). There were significant differences between SH UH patients with respect...
Abstract Background Compared to all other racial groups, black Americans are most likely be diagnosed with colorectal cancer (CRC) and die from the disease. These disparities have been largely attributed social economic conditions that impact prevalence of co-morbidities access quality health care. However, molecular cellular differences in CRC tumors between white subjects remain uncharacterized. Methods We analyzed paired tumor adjacent normal RNA sequencing reads collected 15 18 at...
INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of colorectal cancer. Retrospective studies have shown that T2DM adenoma (CRA), but there no clear consensus on the effects glycemic control and insulin resistance CRA development in subjects T2DM. In this prospective study, we investigated control, resistance, antihyperglycemic medication use incidence advanced METHODS: We measured fasting glucose, insulin, hemoglobin A1c, C-peptide levels undergoing routine...
Abstract Background U.S Multi-Society Task Force of Colorectal Cancer (MSTF) has suggested that screening begin at a younger age in Blacks to detect precancerous adenomas. Our group conducted multi-institution retrospective study clinical data collected 2012 identify biological factors associated with adenoma detection. However, the results investigation revealed included Urban Safety Net Hospital (USNH) had relatively lower detection rate (ADR) may have confounded other analysis study....
Abstract Background Fecal microbiota transplantation (FMT) is an effective treatment of recurrent Clostridioides difficile infections (rCDI). In comparison, FMT has more limited efficacy in treating either ulcerative colitis (UC) or Crohn’s disease (CD), two major forms inflammatory bowel diseases (IBD). We hypothesize that recipients with rCDI and/or IBD have baseline fecal bile acid (BA) compositions differ significantly from their healthy donors and may be normalized by FMT. Aim To study...