A5082944709- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Pregnancy and preeclampsia studies
- Renin-Angiotensin System Studies
- Biomedical Research and Pathophysiology
- Dialysis and Renal Disease Management
- Parasitic Infections and Diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal function and acid-base balance
- Cell Adhesion Molecules Research
- Genetic and Kidney Cyst Diseases
- Liver Disease and Transplantation
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Blood disorders and treatments
- Chronic Kidney Disease and Diabetes
- Metabolism and Genetic Disorders
- Methemoglobinemia and Tumor Lysis Syndrome
- Magnesium in Health and Disease
- Potassium and Related Disorders
- Amoebic Infections and Treatments
Pomeranian Medical University
2015-2025
New York Academy of Medicine
2003
The Blastocystis sp. is a common enteric parasite found in humans and various animals. spp. infections may be asymptomatic or symptomatic, with gastrointestinal extra-intestinal symptoms, such as diarrhea, nausea, abdominal pain, bloating, vomiting, anorexia. disease leading to symptoms usually observed participants immune deficiency. We report the case of weight loss diarrhea infection 64-year-old renal transplant recipient.
Diarrhea is a common occurrence following vascular organ transplantation, including kidney transplants. It can be induced by non-infectious factors, adverse effects of immunosuppressive drugs, or infectious agents such as viruses, bacteria, fungi, parasites. Intestinal protozoan parasites, include Cryptosporidium spp., are causes diarrhea particularly in immunocompromised patients. This review aims to summarize reports on epidemiology, pathogenesis, clinical presentation, diagnosis, and...
In the pharmacological treatment of prostate cancer, benign prostatic hyperplasia and androgenetic alopecia finasteride is commonly used. This drug inhibits 5α-reductase type 2, which why affects androgen homeostasis, since testosterone (T) cannot be reduced to dihydrotestosterone (DHT). As studies on sex-related renal injuries suggest a high probability androgen-induced dysfunction, aim this study was determine potential harmful effects kidneys rats. The performed sexually mature male...
To analyse the impact of most commonly used immunosuppressive drugs on occurrence apoptosis in native kidneys Wistar rats.The study involved 36 rats. animals being grouped according to regimen (tacrolimus, mycophenolate mofetil, cyclosporine A, rapamycin and prednisone). The rats all groups were treated with a 3-drug protocol for 6 months. medication dose was adjusted based available literature data. No administered control group. then killed. Autopsies performed isolated histopathology (HE...
Pregnancy puts a significant additional strain on kidneys. The aim of our study was to investigate the impact immunosuppressive drugs changes in native kidneys female Wistar rats after exposure during pregnancy. conducted 32 dams, subjected regimens commonly used therapy human kidney transplant recipients (cyclosporine A, mycophenolate mofetil and prednisone; tacrolimus, cyclosporine everolimus prednisone). animals received for 2 weeks before pregnancy 3 In all treated dams lower body weight...
Active vitamin D (1,25-dihydroxyvitamin D₃), PTH, fibroblast growth factor-23 (FGF-23) and Klotho protein are key regulators of phosphate metabolism. Hyperphosphatemia increased FGF-23 level in patients with end-stage renal disease associated morbidity mortality. The relationships among metabolism still being investigated. FGF-23, the humoral factor involved metabolism, is strongly serum phosphorus level. Klotho, a transmembrane expressed primarily tubules, functions as an obligatory...
Immunosuppressive drugs and their active metabolites can cross the placental barrier enter fetal circulation. The adverse effects on fetus include chromosomal aberrations, structural malformations, organ-specific toxicity intrauterine growth retardation. aim of our study was to investigate impact "safe" "contraindicated" immunosuppressive birth defects in juvenile Wistar rats after exposure pregnant female these drugs.The conducted 32 rats, subjected regimens most commonly used therapy human...
Post-transplant erythrocytosis (PTE) is estimated at 5-20%. Angiotensin II generated by angiotensin I-converting enzyme (ACE) stimulates erythropoiesis. The highest activity of ACE observed in DD genotype. question arises if gene polymorphism influences PTE.One-year prospective study included 89 kidney recipients (28 women and 61 men).Thirty-four (38%) proved to be genotype, 36 (40%) ID, 19 (22%) Absolute PTE [hematocrit level (HCT) >50% RBC > 5.5 mln/mm(3)] was found 14 (19%) patients....
BACKGROUND:It has been observed that the use of immunosuppressive drugs in patients after transplantation vascularized organs may be associated with changes concentration certain fractions plasma proteins. The these proteins was correlated an increased risk occurrence stage 3 chronic kidney disease (CKD). This article examines effect most commonly used on Wistar rats. MATERIAL AND METHODS:The study involved 36 rats grouped according to regimen (tacrolimus, mycophenolate mofetil, cyclosporine...
This experimental study assessed the impact of medications frequently used after kidney transplantation on immune system pregnant female Wistar rats. The evaluates medications, both approved and contraindicated during pregnancy in common therapeutic combinations. was conducted 32 rats, subjected to immunosuppressive regimens most commonly therapy human transplant recipients (cyclosporine A, mycophenolate mofetil prednisone; tacrolimus, cyclosporine everolimus prednisone). animals received...
Background: In our study, we assessed the impact of immunosuppressive drug combinations on changes in immune system juvenile Wistar rats exposed to these drugs during pregnancy. We primarily concentrated two organs – thymus and spleen. Methods: The study was conducted 40 (32+8) female administered full half dose drugs, respectively, subjected regimens commonly used therapy human kidney transplant recipients ([1] cyclosporine A, mycophenolate mofetil, prednisone; [2] tacrolimus, [3]...
Background. Determination of clearance endogenous creatinine using its plasma and urinary concentration (standard clearance), Cockroft Gault formula, or MDRD formula (estimated clearance) is commonly performed for assessment glomerular filtration rate. Although the evaluation renal function in this way useful, it biased with an error resulting from secretion tubules. This can be reduced by determining after administration cimetidine, which competitively blocks tubular transport. Methods. The...
Immunosuppressive drugs are widely used to avoid graft rejection, but they also known be strongly hepatotoxic. The goal of the current study was determine: (i) immunoexpression SOD1, CAT, GPX1; (ii) concentration MDA, GSH; (iii) activity SOD, GPX, in native liver a pregnant female rats undergoing immunosuppressive therapy. based on archival material obtained from Department Nephrology, Transplantology and Internal Medicine Independent Public Clinical Hospital No. 2 at Pomeranian Medical...
Kidney transplantation remains the treatment of choice in end-stage kidney disease. The introduction new immunosuppressive drugs has significantly extended survival time individuals after KTx, together with improving their quality life. As a consequence, number women planning motherhood is also increasing. Despite strict specialist control, such pregnancies are still considered high-risk, as impact on fetal development very significant. This study evaluates effect most common schemes...