A5030626167- Family Support in Illness
- Childhood Cancer Survivors' Quality of Life
- Family and Disability Support Research
- Physiological and biochemical adaptations
- Marine Biology and Ecology Research
- Marine Bivalve and Aquaculture Studies
- Calcium Carbonate Crystallization and Inhibition
- Insect and Arachnid Ecology and Behavior
- Marine Biology and Environmental Chemistry
- Plant and animal studies
- Cephalopods and Marine Biology
- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- Insect and Pesticide Research
- Pancreatic function and diabetes
- Magnetic and Electromagnetic Effects
- Genetics and Neurodevelopmental Disorders
- Protist diversity and phylogeny
- Pharmacological Receptor Mechanisms and Effects
- Parkinson's Disease Mechanisms and Treatments
- Microtubule and mitosis dynamics
- Pharmacogenetics and Drug Metabolism
- Proteins in Food Systems
- Calcium signaling and nucleotide metabolism
- Genetic Neurodegenerative Diseases
RWTH Aachen University
1990-2025
Maastricht University
2024
Integrated Oncology (United States)
2024
Centrum für Integrierte Onkologie
2022
Universitätsklinikum Aachen
2021-2022
Utrecht University
1982-2001
Abstract Intracellular accumulations of altered, misfolded proteins in neuronal and other cells are pathological hallmarks shared by many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Mutations several genes give rise to familial forms ALS. Sigma receptor 1 have been found cause a juvenile form ALS frontotemporal lobar degeneration (FTLD). We recently described altered localization, abnormal modification loss function SigR1 sporadic In order further elucidate the...
Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of motor neurons (MNs) and their target muscles. Misfolded proteins which often form intracellular aggregates are a pathological hallmark ALS. Disruption functional interplay between protein degradation (ubiquitin proteasome system autophagy) RNA-binding homeostasis has recently been suggested as an integrated model that merges several ALS-associated into common pathophysiological pathway. The E102Q mutation...
•Care and case management for families with parental cancer underage children such as family-SCOUT is feasible.•Can be implemented in an outreach setting centered on a comprehensive center.•Is significantly associated meaningful reduction of psychosocial distress at the parent level. BackgroundCancer patients minor but also their suffer from significant psychological comorbidity. Protective factors predicting successful coping are well known. Corresponding systematic interventions rare...
Abstract The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status that crucial for adaptive response to limited availability. AMPK implicated in regulation many processes, including autophagy. However, precise mechanisms by which controls these processes and identities relevant substrates are not fully understood. Using microarrays, we identify Cyclin Y as an substrate phosphorylated at Serine 326 (S326) both vitro cells. Phosphorylation S326 promotes its...
Abstract Purpose Single motherhood is associated with increased psychosocial risks, affecting both mothers and their minor children. However, little known about the specific impact of maternal cancer in single (SMs). This study compared psychological burden, quality life, problems, parental concerns between SMs partnered (PMs) affected by caring for Methods Cross-sectional analysis baseline data from a multicenter, non-randomized, controlled trial Germany (Family-SCOUT). PMs were assessed...
Introduction: Parental cancer affects the whole family and can have negative impact on as a system well single members. This multicentre, prospective, interventional non‐randomized family‐SCOUT study aimed to implement comprehensive psychosocial intervention provide support for during after disease. The purpose of this is analyse contextual factors that subjective perceived effectiveness family‐scout families affected by parental from healthy parents’ perspective. Methods: Semi‐structured...
Abstract Background Families with minor children affected by parental cancer are at risk of considerable emotional and organizational stress that can severely burden all family members. So far, there has been a lack comprehensive support services for families. The aim this project is to implement evaluate complex psychosocial intervention these families providing advice, information, care on an emotional, psycho-social, communicative level during after the experience across healthcare...
Abstract. To study the reproductive potential of workers in stingless bee Trigona (Tetragonisca) angustula Illiger (Apidae, Meliponinae), we examined morphological quality their eggs. Worker‐eggs were all placed on inside upper wall brood cells. Normally, such eggs are consumed by queen and therefore referred to as trophic. The provisioning oviposition processes queenright colonies characterized occurrence circular aggregations workers, ‘rosettes’, around broodcell opening immediately after...
ABSTRACT In the first polar lobe of egg Bithynia tentaculata a cup-shaped mass small vesicles is described, which fills greater part lobe. It named ‘vegetal body’. With methyl green-pyronin vegetal body stains clearly, but after treatment with RNase no staining occurs, thus indicating presence RNA. The great importance for further development embryo and it argued that could be morphogenetic cytoplasm, responsible developmental effects
Abstract Purpose Within families affected by parental cancer, open communication impacts the well-being of parents and their children; however, limited research exists on patterns in these families. This sub-study addresses this through Family-SCOUT study, a multicenter, prospective, interventional, non-randomized investigation with intervention (IG) control group (CG). The purpose was to identify compare differences between IG CG as part process evaluation. question addressed both groups:...
This study aimed to assess the feasibility of a comprehensive psychosocial intervention for families coping with parental cancer.
Abstract Introduction Currently, no treatment that delays with the progression of Friedreich ataxia is available. In majority patients caused by homozygous pathological expansion GAA repeats in first intron FXN gene. Nicotinamide acts as a histone deacetylase inhibitor. Dose escalation studies have shown, short term dosages up to 4 g/day increase expression mRNA and frataxin protein levels asymptomatic heterozygous gene carriers. The long-term effects on clinical endpoints, activities daily...
Abstract. As in many other stingless bees, Melipona bicolor Lepeletier (Apidae: Meliponinae) workers lay two morphologically distinct types of eggs: slender ones that have a typical patterned chorion, and larger lack this pattern. In paper we report on the relation between egg morphology behaviour such eggs. most cases, laying each these is accompanied by unique sequence behaviours. After worker has laid unpatterned type egg, she generally leaves cell, giving queen possibility eating egg....
ABSTRACT Some novel structural features of the polar lobe egg Crepidula are described. The significance two kinds aggregate is discussed in relation to morphogenetic factors present lobes generally. Surface configurations also
In the first polar lobe of egg Bithyma tentaculata there is a cup-shaped mass small vesicles rich in RNA, called vegetal body. It passed to CD blastomere with and then its contents are distributed C D. When removed, embryos form neither mesentoblast nor mesoderm bands. They fail establish bilateral symmetry or eyes, foot, operculum shell. AB half develop only structures found lobeless embryos, while halves dependent adult such as foot AD- BC-2/4-embryos similarly both have structures. Three...
Families with one parent suffering from cancer are exposed to extraordinary emotional and organizational burdens, affecting underaged children. To help coordinated access social logistic support options thus reduce the stress on family members, project Brückenschlag was founded. The aim of this paper evaluate implementation pilot following healthcare utilization model by Andersen.
Rat intestinal epithelial cells were isolated by EDTA-chelation, combined with gentle shaking (modified Weiser procedure) or strong longitudinal vibration (Harrison/Webster procedure). Both methods yield large numbers of viable and are relatively easy to use. Electronmicroscopical biochemical data indicate that cell fractions from different levels the villous region can be obtained only modified procedure. When mechanical forces involved (Harrison-Webster villus epithelium is released...
Summary In late previtellogenic oocytes nuage material accumulates in the vicinity of nucleus and is often seen to be intimately associated with cisternae endoplasmic reticulum (ER). A similar association observed Ilyanassa has given rise proposition that granules become completely enclosed an envelope ER this structure transformed into so-called double-membrane vesicles, organelles which have only been found eggs Nassarius. This study provides evidence that, Nassarius, a temporary...