A5102884076- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Retinal Development and Disorders
- Cell Adhesion Molecules Research
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma Management and Diagnosis
- Conservation, Biodiversity, and Resource Management
- Congenital Diaphragmatic Hernia Studies
- Speech Recognition and Synthesis
- Protein Degradation and Inhibitors
- Intraocular Surgery and Lenses
- Plant Pathogens and Fungal Diseases
- Speech and Audio Processing
- Phagocytosis and Immune Regulation
- Insect and Arachnid Ecology and Behavior
- Protease and Inhibitor Mechanisms
- Innovation in Digital Healthcare Systems
- Extracellular vesicles in disease
- Biometric Identification and Security
Kyushu University
2014-2024
Kyoto Institute of Technology
2022
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2021
Shinshu University
2017
Osaka City General Hospital
2010-2012
Tokushima University
2004
Choroidal neovascularization (CNV) is a serious complication of age‑related macular degeneration. The aim the present study was to investigate expression and distribution M1 M2 macrophages in laser‑induced CNV adult mouse model. mRNA levels M1, pan macrophage markers, macrophage‑associated angiogenic cytokines, were determined by reverse transcription‑quantitative polymerase chain reaction. Immunofluorescence studies performed determine location macrophages. markers increased greater extent...
Purpose: To investigate the roles played by M2 macrophages in a mouse model of oxygen-induced retinopathy (OIR). Methods: Oxygen-induced was induced C57BL/6J mice exposing postnatal day seven (P7) pups to 75% oxygen and then returning them room air at P12. Real-time RT-PCR immunofluorescence staining were used assess levels distributions different macrophage markers. Bone marrow–derived M1 mannosylated clodronate liposomes (MCLs) injected into vitreous on P12 examine effects P17. cocultured...
To determine whether vitreal concentrations of MCP-1, IL-6 and IL-8 are altered after vitrectomy in patients with proliferative diabetic retinopathy (PDR) to investigate the levels these cytokines associated postoperative macular oedema.Vitreous samples were collected from 36 eyes 33 PDR before pars plana without intraocular lens (IOL) implantation, also same during IOL implantation surgery approximately 7 months initial vitrectomy. Levels IL-6, vascular endothelial growth factor measured by...
Abstract Hypoxia-induced retinal neovascularization is a major pathological condition in many vision-threatening diseases. In the present study, we determined whether interleukin (IL)-12, cytokine that regulates angiogenesis, plays role mouse model of oxygen-induced retinopathy (OIR). We found expressions mRNAs both IL-12p35 and IL-12p40 were significantly reduced OIR retinas compared to room air-raised control. The sizes avascular areas neovascular tufts larger knock-out (KO) mice than wild...
<b><i>Objective:</i></b> To examine the relationship between early response to anti-vascular endothelial growth factor (VEGF) treatment and visual prognosis. <b><i>Methods:</i></b> We retrospectively separated 20 patients with persistent diabetic macular edema (DME) into two responder status groups based on reduction of central thickness (CMT) from baseline month 3: a delayed group (DRG) (≤25% CMT reduction, <i>n</i> = 11) an...
<b><i>Purpose:</i></b> To compare the effectiveness of intravitreal ranibizumab (IVR) for diabetic macular edema (DME) between eyes with and without previous vitrectomy. <b><i>Procedures:</i></b> We prospectively assessed best-corrected visual acuity (BCVA) central thickness (CMT) after IVR 6 months. <b><i>Results:</i></b> There were no significant differences in baseline BCVA CMT both groups. In nonvitrectomized group...
Abstract Ischemic proliferative retinopathy (IPR), such as diabetic (PDR), retinal vein occlusion and of prematurity is a major cause vision loss. Our previous studies demonstrated that periostin (PN) tenascin-C (TNC) are involved in the pathogenesis IPR. However, interactive role PN TNC angiogenesis associated with IPR remain unknown. We found significant correlation between concentrations PDR vitreous humor. mRNA protein expression were pre-retinal fibrovascular membranes excised from...
Retinal neovascularization (NV) due to retinal ischemia remains one of the principal causes vision impairment in patients with ischemic diseases. We recently reported that periostin (POSTN) may play a role development preretinal fibrovascular membranes, but its NV has not been determined. The purpose this study was examine expression POSTN retinas mouse model oxygen-induced NV. also studied function on using Postn KO mice and human endothelial cells (HRECs) culture. In addition, we used...
Age-related macular degeneration (AMD) and central serous chorioretinopathy (CSC) are common diseases that can cause vision loss in older younger populations. These share pathophysiological conditions derived from retinal pigment epithelium (RPE) dysfunction. Tumor necrosis factor receptor superfamily 10A (TNFRSF10A)-LOC389641 with the same lead single-nucleotide polymorphism (SNP) (rs13278062) is only overlapped susceptibility locus found both AMD CSC through genome-wide association...
We report the case of a 17-year-old man with precursor B-lymphoblastic lymphoma involving an intracardiac mass and myocardial infiltration. Intensified chemotherapy followed by autologous peripheral blood stem cell transplantation resulted in long-term complete remission for over 5 years. As most frequent sites involvement are skin, soft tissue, bone, lymph nodes, reports cases harboring cardiac relatively few. This is rare displaying involvement, which infiltration was one initial manifestations.
This study aims to investigate the changes in metamorphopsia after administering treat-and-extend regimen of anti-vascular endothelial growth factor therapy for branch retinal vein occlusion-associated macular edema. We retrospectively examined 27 patients (27 eyes) with macula edema due occlusion who received intravitreal injections agents using ≥18 months. evaluated best-corrected visual acuity, central thickness, recurrence, and amount quantified by M-CHARTS. The acuity (logarithm minimum...
Epiretinal proliferation (EP) is thought to be glial cell arising from the inner retina, seen in cases of lamellar or full-thickness macular holes (FTMH). Embedding EP within hole considered supportive for FTMH closure and functional recovery. We report a recurrent case that was successfully closed after primary vitrectomy with embedding technique. In surgery, internal limiting membrane (ILM) peeling avoided reduce potential risk retinal nerve fiber layer damage associated glaucoma. The...
Abstract Many species of fish, bird, and insect form groups individuals that move together, called schools, flocks, or swarms, characteristic shape speed. Here we study a model traces movements many individuals, in which each individual moves at constant speed, changes its movement angle response to neighbors within radius interaction. Outside short range separation (or repulsion), moving direction achieve similar as (alignment) toward them (cohesion). Between pair an interaction range, both...