A5073045675- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Biomedical Text Mining and Ontologies
- Airway Management and Intubation Techniques
- Clinical practice guidelines implementation
- Restraint-Related Deaths
- Atrial Fibrillation Management and Outcomes
- Anatomy and Medical Technology
- Biomarkers in Disease Mechanisms
- Peptidase Inhibition and Analysis
- Ethics in Clinical Research
- Salivary Gland Tumors Diagnosis and Treatment
- Surgical Simulation and Training
- Galectins and Cancer Biology
- Ovarian cancer diagnosis and treatment
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Screening and Detection
- Thyroid Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
Aarhus University Hospital
2018-2025
Aarhus University
2021
Odense University Hospital
2008-2018
University of Southern Denmark
2012-2016
Regional as well national series show an increasing incidence of thyroid cancer largely small size papillary carcinoma (PTC). Prognostic scoring systems have been developed, but these do not take into account the rapidly changing case mix, and adjustments may be required. The purposes this study were to evaluate treatment outcomes analyze value older prognostic tested on a relatively new, unselected cohort PTC patients.This was prospective conducted in Denmark, which has population 5.5...
Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on factors predicting long-term biochemical cure MTC patients are nonexistent at a level. A nationwide retrospective cohort study Denmark from 1997 2014 was conducted, aiming detect with survival similar that and identify prognostic for disease-specific cure.The included 220 identified Danish between 2014. As representative sample population, reference matched 50:1...
Background: With an observed general rise in papillary thyroid carcinoma incidence, microcarcinoma (PMC) is accordingly found more frequently and often incidentally by histological examination of surgical specimens from presumed benign disease. Only a few studies have specifically addressed the prognosis PMC, they been limited to retrospective single-center studies. Methods: This was national, unselected, prospective cohort study 406 patients diagnosed Denmark 1996 2008. Objective: The aim...
Recent studies have shown a significant increase in the temporal trend of medullary thyroid carcinoma (MTC) incidence. However, it remains unknown to which extent sporadic (SMTC) and hereditary MTC (HMTC) affect incidence over time. We conducted nationwide retrospective study using previously described RET cohorts combined with review medical records, pedigree comparison relevant registries. The included 474 patients diagnosed Denmark between 1960 2014. In period from 1997 2014, we recorded...
Background: Multiple endocrine neoplasia type 2A (MEN 2A) is a rare hereditary cancer syndrome caused by pathogenic variants in the rearranged during transfection (RET) gene and characterized medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO), primary hyperparathyroidism (PHPT), cutaneous lichen amyloidosis (CLA), Hirschsprung’s disease. Phenotypic data on RET C611Y variant remain sparse. Consequently, we aimed to establish clinical risk profile. Methods: We conducted nationwide...
Studies of primary hyperparathyroidism (PHPT) in multiple endocrine neoplasia type 2A (MEN 2A) shows divergence frequency, disease definition, reporting clinical characteristics and traces selection bias. This is a nationwide population-based retrospective study PHPT MEN 2A, suggesting representative with complete strict definition. The Danish cohort 1930-2021 was used. Of 204 cases, 16 had PHPT, resulting frequency 8% (CI, 5-12). Age-related penetrance at 50 years 4-15). seen the American...
Development of hypoparathyroidism (hypoPT) after total thyroidectomy (TT) may increase the risk kidney-related morbidity. We aimed to examine hypoPT and chronic kidney disease (CKD) in patients undergoing TT Denmark over a 20-year period.
Papillary microcarcinomas (PMC) of the thyroid gland are defined according to The WHO Committee as papillary carcinomas measuring 10 mm or less in diameter. A large proportion these tumours found coincidentally treatment symptomatic goitre and most cases follow an indolent course with excellent prognosis. However, a more aggressive behaviour regional distant metastases does occur. aim this study was evaluate if immunohistochemical markers cyclin D1 galectin-3 might indicate presence...
A recent study proposed new TNM groupings for better survival discrimination among stage groups medullary thyroid carcinoma (MTC) and validated these in a population-based cohort the United States. However, it is unknown how well perform populations outside Consequently, we conducted first aiming to evaluate if recently provide than current American Joint Committee on Cancer (AJCC) staging system (seventh eighth edition) nationwide MTC This retrospective included 191 patients identified from...
Total thyroidectomy is associated with a high risk of postoperative hypoparathyroidism, mainly due to the unintended surgical damage parathyroid glands or their blood supply. It possible that surgeons who also perform surgery see lower rates hypoparathyroidism. In single institution, we investigated effects restricting total operations for Graves' disease two performed both thyroid and surgeries. We aimed evaluate hypoparathyroidism in 10-year period primary attention toward patients...
Nonanaplastic follicular cell-derived thyroid carcinoma (NAFCTC) includes differentiated- (DTC) and poorly differentiated (PDTC). DTC has an excellent prognosis, while PDTC is situated between anaplastic carcinomas. Short-term studies suggest that patients diagnosed only on tumor necrosis and/or mitosis have a prognosis similar to those according the TURIN proposal. The purpose of this study was evaluate for NAFCTC based long-term follow-up illuminating significance mitosis. A cohort 225...
The completeness of REarranged during Transfection (RET) testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the on a population level is unknown. Similarly, it unknown if first Danish guidelines from 2002, recommending RET all MTC patients, improved Denmark. We conducted nationwide retrospective cohort study aiming to evaluate cohort. Additionally, we aimed assess before and after publication characterize who had not been tested.The included 200...
A woman in her mid-80’s collapsed while home due to a sudden onset of swelling on neck compromising the airway. She was intubated on-site and brought trauma-centre where she diagnosed with an intrathyroidal bleeding compression trachea. subacute left sided thyroid lobectomy performed, giving immediate relief displaced compressed The patient discharged after 3 days. final histopathological examination revealed microfollicular adenoma extensive bleeding.
Abstract Objective Total thyroidectomy (TT) carries a risk of hypoparathyroidism (hypoPT). Recently, hypoPT has been associated with higher overall mortality rates. We aimed to evaluate the frequency and in patients undergoing TT Denmark covering 20 years. Design Retrospective Cohort study. Patients measurements Using population‐based registries, we identified all Danish individuals who had undergone between January 1998 December 2017. included comparison cohort by randomly selecting 10...
Abstract Background Clinical practice guidelines aim to help with decision making. However, their quality differs. Guidelines of low are a waste resources and can cause patient harm. We compared the Norwegian, Danish, Swedish on papillary thyroid cancer those American Thyroid Association (ATA). Methods Three pairs appraisers independently rated using AGREE II-instrument, validated tool for assessing guideline quality. Further, recommendations extent surgery in low-risk PTC; prophylactic...
Operation with a 3D exoscope has recently been introduced in clinical practice. The consists of two cameras placed front the operative field. Images are shown on large screen high resolution. system can be used to enhance precise dissection and provides new possibilities for improved ergonomics, fluorescence, other optical-guided modalities.
Abstract Objective. CoolSeal is a new vessel sealing system for dissection and hemostasis during surgery. No clinical studies have investigated safety, advantages or disadvantages regarding the use of this device. The aim present study was to investigate safety compare it with conventional ligation technique LigaSure total thyroidectomy. We hypothesized that would reduce operating time bleeding without complications increase. Study design represents retrospective cohort tertiary reference...