Endothelial progenitor cells (EPCs) may be recruited from the bone marrow to sites of tissue regeneration sustain neovascularization and reendothelialization after acute vascular injury. This feature makes them particularly suitable for cell-based therapy. In mature endothelium, store-operated Ca(2+) entry (SOCE) is activated following emptying inositol-1,4,5-trisphosphate-sensitive stores, controls a wide number functions, including proliferation, nitric oxide synthesis, permeability. The...

A post-COVID condition can reduce activity and quality of life, resulting in a significant socioeconomic health burden. Understanding its impact on patients' is important for the development personalized rehabilitation interventions. An independent association between obesity was found because complications comorbidities.Sixteen patients with symptoms (i.e., dyspnea, pain, poor sleep quality, muscle fatigue), admitted to Istituto Auxologico Italiano, Piancavallo (VB), Italy, were recruited...

Pain severity, depression, and sleep disturbances are key targets for FM rehabilitation. Recent evidence suggests that whole-body cryostimulation (WBC) might be an effective add-on treatment in the management of FM. The purpose this study was to evaluate effects WBC intervention a multidisciplinary rehabilitation program on pain intensity, depressive symptoms, disease impact, quality, performance-based physical functioning sample patients with obesity. We performed randomized controlled...

A growing body of work suggests that whole-body cryostimulation (WBC) could play a role as promising adjuvant therapy in various conditions rehabilitation interest. In fact, WBC is currently being used to relieve symptoms rheumatoid arthritis, fibromyalgia, ankylosing spondylitis, depression and anxiety, multiple sclerosis, sleep disturbances, muscle soreness after strenuous physical exercise, post-Covid syndrome obesity. not only symptomatic but rather represents an "adaptation therapy"...

Celiac disease is a chronic inflammatory disorder of the small bowel induced in genetically susceptible subjects by gluten ingestion. Diarrhoea, weight loss and malabsorption represent major clinical presentation disease. Here we examined possible alteration expression localization water channels [AQPs (aquaporins)] some solute transporters duodenal mucosa celiac patients. Duodenal biopsies from untreated celiacs, treated healthy controls were considered present study. The expressions AQPs...

Hematopoietic progenitor and stem cells (HPSCs) have been employed in cell-based therapy (CBT) to promote neovascularisation regeneration of ischemic organs, such as heart limbs. Furthermore, endothelial (EPCs) may favour tumour growth adverse vascular targeting treatment by incorporating into neovessels. CBT is hampered the paucity HPSCs harvested from peripheral blood suffers several pitfalls, including differentiation outcome transplanted low percentage engrafted cells. Therefore, will...

Purpose: Individuals with fibromyalgia and obesity experience significant impairment in physical functioning. Pain catastrophizing, kinesiophobia, pain acceptance have all been identified as important factors associated the level of disability. The objective this study was to evaluate role mediators association between perceived severity functioning individuals obesity. Patients Methods: In cross-sectional study, 165 women completed self-report questionnaires (ie, Numeric Rating Scale),...

Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease among people over age of 50 and occurs with symptoms such as musculoskeletal pain stiffness in neck, shoulders hips. To date, corticosteroids represent cornerstone PMR treatment, although it well known that their prolonged use associated several adverse effects, making crucial to find therapeutic alternatives use. The purpose this case report was describe effectiveness 10 whole-body cryostimulation (WBC) sessions...

Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease among people over 50 and occurs with symptoms such as musculoskeletal pain stiffness in neck, shoulders, hips. To date, corticosteroids represent cornerstone of PMR treatment. However, it well known that their prolonged use associated several adverse effects, making crucial to find therapeutic alternatives. The purpose this case report was describe effectiveness 10 whole-body cryostimulation (WBC) sessions on a...

Central sensitisation is defined as a multifactorial etiopathogenetic condition involving an increase in the reactivity of nociceptive neurons and alterations pain transmission perception central nervous system. Patients may present with widespread chronic pain, fatigue, sleep disturbance, dizziness, psychological (e.g., depression, anxiety, anger) social impairment. Pain can be spontaneous onset persistence, characterised by exaggerated response spread beyond site origin, sometimes...

Background: Chronic shoulder pain may cause significant functional disability and reduced psychosocial well-being. Detailed Case Description: In this case, we propose the use of neuroscience education whole-body cryostimulation (WBC) to treat a 64-year-old woman with severe limitations chronic right pain. The aim was overcome kinesiophobia improve her motor function, autonomy, quality life. Functional clinical assessments were conducted at admission, discharge, one-month follow-up via phone...

The ion pump Na+, K+-ATPase (NKA) is a receptor for the cardiotonic steroid ouabain. Subsaturating concentration of ouabain triggers intracellular calcium oscillations, stimulates cell proliferation and adhesion, protects from apoptosis. However, it controversial whether ouabain-bound NKA considered signal transducer. To address this question, we performed global analysis protein phosphorylation in COS-7 cells, identifying 2580 regulated events on 1242 proteins upon 10- 20-min treatment with...

Given the severity and prevalence of post-COVID-19 symptoms in general population, identification boosters for rehabilitation programs appears to be paramount importance. The purpose this case series is provide some preliminary evidence about role whole-body cryostimulation (WBC) as an effective adjuvant recovery patients with condition (PCC). We recruited seven previously confirmed SARS-CoV-2 infection PCC different severities a comprehensive program, including WBC. main were dyspnea,...

Emerging evidence suggests that there is a significant genetic component to human longevity. One or more variants located on chromosome 9p21.3 and tagged by the single-nucleotide polymorphism (SNP) rs1333049 (G/C) are major risk factors for age-related disorders, including acute myocardial infarction (AMI), stroke, dementia. We hypothesized this locus may have widespread effects aging phenotypes and, as such, influences ability achieve long healthy life.The aim of study was assess whether...

Phantom Limb Pain (PLP) is a challenging condition affecting significant proportion of amputees. In this article we describe the case 54-year-old Paralympic athlete with Syndrome following right leg amputation and widespread sports-related enthesitic pain, who underwent Whole Body Cryostimulation (WBC) cycle, an emerging treatment known for its rapid pain-relieving anti-inflammatory effects. Assessments were conducted before after 10-session WBC including pain quality life assessment, use...

Background: Tinnitus, which is often associated with reduced quality of life, depression, and sleep disturbances, lacks a definitive treatment targeting its pathophysiological mechanism. Inflammatory markers like TNF-α have been linked to tinnitus, thereby underlining the necessity for innovative therapies. This case study investigates potential benefits multi-approach rehabilitation intervention involving whole-body cryostimulation (WBC) 47-year-old male suffering from chronic...

Recent evidence suggests that whole-body cryostimulation (WBC) may be beneficial for patients with fibromyalgia (FM), but little is known about the duration of such effects. The purpose this study was to verify clinical–functional benefits after one cycle WBC. We conducted a follow-up on medium and long-term effects WBC well-being, use pain-relieving/anti-inflammatory medications, pain level, fatigue, sleep quality, psychological aspects as mood anxiety. Twelve months discharge, we...

Background/Objectives: The autonomic nervous system (ANS) is considered one of the mechanisms mediating benefits whole-body cold stimulation (WBC). Nevertheless, different treatment protocols, methodologies employed to assess ANS, and, in particular, difficulties interpreting numerous variables obtained represent important barriers understanding effects WBC on ANS. present study aimed explore cardiac control (CAR) as assessed using a single composite percentile-ranked proxy balance (ANSI),...