A5060833637- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Mosquito-borne diseases and control
- Tissue Engineering and Regenerative Medicine
- Glycosylation and Glycoproteins Research
- Antimicrobial Peptides and Activities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pleural and Pulmonary Diseases
- Cancer, Hypoxia, and Metabolism
- Smoking Behavior and Cessation
- TGF-β signaling in diseases
- Cancer Research and Treatments
- Biomedical Research and Pathophysiology
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Air Quality and Health Impacts
- Renal and related cancers
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- Macrophage Migration Inhibitory Factor
Taipei Medical University
2022-2025
National Cheng Kung University
2014-2019
Embryonic development and tumor genesis share numerous similarities, with OCT4 standing out as a pivotal transcription factor in embryonic development. Expression of is associated poor prognosis lung adenocarcinoma. VEGF-correlated chemokine-1 (VCC-1), also known C-X-C motif chemokine ligand 17 (CXCL17), has been suggested to play role promoting angiogenesis metastasis. In the present study, we show positive correlation between expression levels metastatic potential, where an increase...
Abstract Sepsis-induced acute lung injury (ALI) involves severe dysfunction and leads to high morbidity mortality rates due the lack of effective treatments. The somatic nuclear autoantigenic sperm protein (sNASP)/tumor necrosis factor receptor-associated 6 (TRAF6) axis plays a crucial role in regulating inflammatory responses during sepsis through Toll-like receptor 4 (TLR4) signaling. However, it is unclear whether deubiquitinating enzymes affect TRAF6/sNASP axis. In this study, we showed...
Elevated expression of prothymosin α (ProTα), a 12.5-kDa acidic protein encoded by the PTMA gene, is frequently observed in cancers, including lung cancer, where it correlates with poor prognosis. Although ProTα primarily localized to nucleus, advanced-stage tumors exhibit its translocation cytoplasm, indicating potential involvement disease progression. In this study, we aim elucidate molecular mechanisms which nuclear regulates epithelial-to-mesenchymal transition (EMT) and metastasis...
Elevated expression of prothymosin α (ProT) is frequently observed in cancers, but the underlying molecular mechanism remains poorly understood. Here, we report clinical relevance ProT and its correlation with lung cancer progression. We have shown that was highly expressed early-stage cancer, exhibiting nuclear localization; on contrary, a loss detected late-stage tumor specimens. Furthermore, impaired cell migration, suppressed TGF-β-induced epithelial-to-mesenchymal transition...
Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (lncRNA), promotes progression in different cancers. Crosstalk between HOTAIR documented. Prothymosin α (ProT) plays important roles inflammation. potential link ProT, cisplatin-induced cachexia remains unexplored. Here, we investigated contribution dissected signaling cascade involving...
Emphysema, a major consequence of chronic obstructive pulmonary disease (COPD), is characterized by the permanent airflow restriction resulting from enlargement alveolar airspace and loss lung elasticity. Transforming growth factor-β (TGFβ) signalling regulates balance matrix metalloproteinase (MMP)/tissue inhibitor (TIMP) to control homeostasis. Patients with COPD have dysregulated TGFβ reduced histone deacetylase (HDAC) activity through epigenetic up-regulation acetylation in promoters...
Abstract Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can be used cellular vehicles delivering oncolytic sites. Since telomerase activity is found in ~90% human carcinomas, but undetected normal adult cells, reverse transcriptase gene (TERT) promoter exploited regulating replication...
Thrombocytopenia is the hallmark finding in dengue virus (DENV) infection. Prothymosin α (ProT) has both intracellular and extracellular functions involved cell cycle progression, differentiation, gene regulation, oxidative stress response, immunomodulation. In this study, we found that ProT levels were elevated patient sera as well DENV-infected megakaryoblasts their culture supernatants. transgenic mice had reduced platelet counts with prolonged bleeding times. Upon treatment DENV plus...
Prothymosin α (ProTα) is a nuclear protein that serves role in oncogenesis, by promoting proliferation and inhibiting apoptosis various malignancies. The present study was designed to investigate ProTα expression resected human non‑small cell lung cancer define the clinicopathological associations of ProTα‑positive cancer. Immunohistochemical staining performed using tumor sample slides from 149 patients with cancer, who underwent surgical resection. Association between following parameters...
Polycystic kidney disease (PKD) is characterized by the expansion of fluid-filled cysts in kidney, which impair function and eventually leads to end-stage renal failure. It has been previously demonstrated that transgenic overexpression prothymosin α (ProT) induces development PKD; however, underlying mechanisms remain unclear. In this study, we used a mouse PKD model sustains kidney-specific low-expression Pkd1 illustrate aberrant up-regulation ProT occurs cyst-lining epithelial cells,...
Abstract Platinum-based drug like cisplatin is the standard first-line to treat patients with bladder cancer. However, tumors may recur and develop into multiple-drug resistant characteristics. The acquisition of resistance conventional chemotherapy a challenge in treatment cancer relapse. Cancer stem cell (CSC) hypothesis has been an attractive theory. CSCs can resist therapeutic assaults, giving rise multiple promotion tumor relapse metastasis. It shown that fraction cells expressing MDR1...
Additional file 1: Table S1. Clinicopathological parameter of the present study population.