A5083425767- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Galectins and Cancer Biology
- Genetic factors in colorectal cancer
- Advanced Biosensing Techniques and Applications
- Systemic Lupus Erythematosus Research
- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- Bioactive Compounds and Antitumor Agents
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
Taipei Medical University
2025
Heilongjiang Academy of Sciences
2016-2024
Harbin Medical University
2014-2024
Guangxi University
2021-2023
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2021
Baylor College of Medicine
2014-2017
Abstract Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer (CRC) patients. The role differentially expressed lncRNAs 5-Fluorouracil chemoresistance has not fully explained. Here, we observed lncRNA H19 was associated with 5-Fu resistance CRC. Quantitative analysis indicated that significantly increased recurrent CRC patient samples. Kaplan–Meier survival high expression tissues free survival. Our functional studies demonstrated promoted cells...
Various 'omics' technologies, including microarrays and gas chromatography mass spectrometry, can be used to identify hundreds of interesting genes, proteins metabolites, such as differential metabolites associated with diseases. Identifying metabolic pathways has become an invaluable aid understanding the genes studying conditions. However, classical methods fail accurately consider joint power gene/metabolite key regions impacted by them within pathways. In this study, we propose a...
// Chen-Dan Zou 1, * , Wei-Ming Zhao Xiao-Na Wang 1 Qiang Li 2 Hui Huang Wan-Peng Cheng Jian-Feng Jin He Zhang Ming-Juan Wu 3 Sheng Tai Chao-Xia Xu Gao 4 Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China General Surgery, the Second Affiliated Hospital Academy Traditional Chinese Medicines, Heilongjiang Science, These authors have contributed equally to this work Correspondence to: Zou, e-mail: zouchaoxia006@126.com Gao, gaoxu_671227@163.com Keywords:...
Cell adhesion molecules (CADMs) comprise of a protein family whose functions include maintenance cell polarity and tumor suppression. Hypo-expression CADM2 gene expression has been observed in several cancers including hepatocellular carcinoma (HCC). However, the role mechanisms HCC remain unclear. The miRNA-10b (miR-10b) tissues lines were detected using real-time PCR Western blotting. Immunofluorescence was used to detect Epithelial-mesenchymal transition (EMT) progression lines....
Angiogenesis, a key factor in ischemic heart disease, is rapidly initiated response to hypoxic or conditions. MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the involvement these control angiogenesis renders them very attractive development new approaches for restoring angiogenic balance. In present study, we explored miR-483-5p, microRNA embedded intron insulin-like growth 2 (Igf2),...
Abstract Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a sequence-specific RNA-binding protein. We had reported that CPEB3 involved in hepatocellular carcinoma (HCC) progression. However, the underlying mechanisms of HCC remain unclear. In this study, we firstly performed RNA immunoprecipitation to uncover transcriptome-wide CPEB3-bound mRNAs (CPEB3 binder) HCC. Bioinformatic analysis indicates binders are closely related cancer progression, especially metastasis. Further...
Abstract Fibroblast activation protein alpha (FAP) is a marker of cancer-associated fibroblast, which also expressed in cancer epithelial cells. However, the role FAP colorectal (CRC) cells remains to be elucidated. Here we investigate expression pattern CRC tissues and prove that upregulated Loss- gain-of-function assays identified promotes migration invasion instead an effect on cell proliferation. Microarray are adopted identify different genes after knockdown gene set enrichment analysis...
Aim: To investigate the effect of hair follicle mesenchymal stem cells (HFMSCs) in ischemic stroke. Materials & methods: Rat transient stroke model was established to verify HFMSC transplantation. Behavioral experiment and TTC staining were used estimate neurological outcome after therapy. Pathological experiments therapeutic roles HFMSCs. Results: HFMSCs inhibited neural apoptosis promoted proliferation. The number around core increased Besides, grafted expressed neuron-specific marker...
Abstract Sepsis-induced acute lung injury (ALI) involves severe dysfunction and leads to high morbidity mortality rates due the lack of effective treatments. The somatic nuclear autoantigenic sperm protein (sNASP)/tumor necrosis factor receptor-associated 6 (TRAF6) axis plays a crucial role in regulating inflammatory responses during sepsis through Toll-like receptor 4 (TLR4) signaling. However, it is unclear whether deubiquitinating enzymes affect TRAF6/sNASP axis. In this study, we showed...
Heme metabolism system is involved in microRNA (miRNA) biogenesis. The complicated interplay between heme oxygenase-1 (HO-1) and miRNA has been observed various tissues diseases, including human malignancy. In the present study, our data showed that stable HO-1 overexpression hepatocellular carcinoma (HCC) cells downregulated several oncomiRs. most stably are miR-30d miR-107. Iron, one of catalytic products, was an important mediator this regulation. Cell function analysis demonstrated...
Colorectal cancer (CRC) is a malignancy that has high morbidity and mortality initiated from accumulative genetic events. Although much effort been made to elucidate the mechanism underlying this disease, it still remains unknown. Here, we discovered novel role for multiple epidermal growth factor-like domains protein 6 (MEGF6) in CRC, namely, induces epithelial-to-mesenchymal transition (EMT) promote CRC metastasis via transforming factor beta (TGFβ)/SMAD signaling pathway.RNA sequencing...
The liver is the most frequent site for metastatic spread in colorectal cancer (CRC) patients, and these patients have much poorer prognosis than those without metastasis. Previous studies shown that IgG Fc binding protein (FCGBP) plays important roles tumorigenesis, progression, prognosis, but its role CRC metastasis remains unclear.In this study, we are aimed to explore significance of FCGBP (LMCRC) patients.We analyzed expression RNA between primary samples Gene Expression Omnibus (GEO)...
Abstract Background The growth and development of muscle stem cells (MuSCs) are significant events known to affect plasticity, disease, meat production, quality, which involves the types functions mRNA non-coding RNA. Here, MuSCs were cultured from Guangxi fetal cattle. RNA sequencing was used analyze expression RNAs during cell proliferation differentiation phases. Results Two thousand one hundred forty-eight mRNAs 888 differentially expressed between phases, including 113 miRNAs, 662...
Substantial cancer genome sequencing efforts have discovered many important driver genes contributing to tumorigenesis. However, very little is known about the genetic alterations of long non-coding RNAs (lncRNAs) in cancer. Thus, there a need for systematic surveys lncRNAs. Through integrative analysis 5918 tumors across 11 types, we revealed that lncRNAs undergone dramatic genomic alterations, which are mutually exclusive with well-known genes. Using hypothesis functional redundancy mutual...
Abstract Premature ovarian insufficiency (POI) is a heterogeneous and multifactorial disorder. In recent years, there has been an increasing interest in research on the pathogenesis treatment of POI, owing to implementation second-child policy China. Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) RNA-binding that can bind specific RNA sequences. CPEB3 affect expression, cellular location, stability target RNAs. Cpeb3 highly expressed ovary; however, its functions remain...
The adenosine triphosphate-binding cassette (ABC) is a large group of proteins involved in material transportation, cellular homeostasis, and closely associated with chemoresistance. ATP-binding protein B4 (ABCB4) member ABCs which has similar structure to ABCB1, but fewer researches were performed. present study aimed investigate the putative mechanism ABCB4 5-fluorouracil (5-Fu) resistance. Then, we found that was significantly down-regulated 5-Fu resistant HCT8 cell lines by polymerase...
Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its cancer metastasis is still ambiguous. In this study, we observed effect HO-1 on mouse mammary carcinoma using vivo tumor model. Our results revealed that overexpression strongly inhibits lung 4T1 cells. vitro analysis, associated indices for epithelial-mesenchymal transition (EMT), migration, and proliferation cells were evaluated. The show EMT, addition,...
The protective role of M(3)-mAChR against apoptosis has been identified previously. However, the underlying mechanisms remain unclear. This study was performed to clarify signaling pathways anti-apoptotic effect mediated by activation in cultured cardiac H9c2 cells.Both rat ventricular cells and with stable expression were used.Activation cabarchol produced on etoposide-induced cells. Forced overexpression further enhanced this effect. Application 4-diphenyl-acetoxy-N-methyl-piperidine...
Abstract Heme oxygenase‐1 (HO‐1), which catalyzes the degradation of heme to iron, carbon monoxide, and biliverdin, performs a cytoprotective function. Previous studies on crystal structure human rat HO‐1 in complex with showed that Gly139His (G139H) Gly143His (G143H) mutants have no HO activity. In present study, we reported effect G139H, G143H, Ser142His mouse reaction vivo vitro . , mutant transfectants, only catalyzed heme, retaining 31.7% wild‐type activity, whereas G139H G143H...