A5050260140- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Parvovirus B19 Infection Studies
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- Dermatological and COVID-19 studies
- Immune Response and Inflammation
- MRI in cancer diagnosis
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Liver physiology and pathology
- Mesenchymal stem cell research
- Tryptophan and brain disorders
- T-cell and B-cell Immunology
- Prenatal Screening and Diagnostics
- Reconstructive Surgery and Microvascular Techniques
- Empathy and Medical Education
- Orthopedic Surgery and Rehabilitation
- 3D Printing in Biomedical Research
- Nerve injury and regeneration
Peking University
2020-2025
Shanghai Medical College of Fudan University
2006-2024
Fudan University Shanghai Cancer Center
2016-2024
Jiangxi Agricultural University
2024
Soochow University
2016-2024
Ruihua Affiliated Hospital of Soochow University
2017-2024
Tongji University
2018-2023
Tongji Hospital
2018-2023
Shanghai University of Medicine and Health Sciences
2022
Southwest University
2022
Clinical settings often face significant obstacles in treating large acute wounds. The alternative of therapeutic approach is needed urgently. Hydrogels derived from natural or synthetic materials may be designed to perform a variety functions for promoting wound healing. Herein, 3D bioprinted hydrogel patch accelerating healing, which fabricated with methacryloyl-substituted gelatin (GelMA) and silk fibroin (SilMA) dual-cross-linked by ultraviolet (UV) light. GelMA added (GelSilMA) shows...
Tissue engineering is a growing research area of great interest because it can produce bionic grafts to replace autologous tissue. Although many molding strategies have been tried, precellularization small-diameter vascular remains challenge. Here, novel approach for fabricating vessels developed through combining nanofiber electrospinning and specially-designed rotary bioprinter. Electrospun poly(ε-caprolactone) (PCL) provides good elasticity, the modification beneficial adhesion...
Background: Identification of pre-invasive lesions (PILs) and invasive adenocarcinomas (IACs) can facilitate treatment selection. This study aimed to develop an automatic classification framework based on a 3D convolutional neural network (CNN) distinguish different types lung cancer using computed tomography (CT) data. Methods: The CT data 1,545 patients suffering from or were collected Fudan University Shanghai Cancer Center. All the preprocessed through mask extraction reconstruction...
Background: Vascular smooth muscle cell (VSMC) migration and proliferation substantially contribute to neointimal hyperplasia related in-stent restenosis. N6-methyladenosine (m6A) catalyzed by the methyltransferase-like 3 (METTL3)-involved methyltransferase complex is most abundant RNA epigenetic modification in eukaryotes, but role of m6A methylation VSMC as well neointima formation remains highly controversial. Methods: Primary human rat VSMCs were utilized for vitro experiments....
BACKGROUND MEX3A is a member of the human homologous gene MEX-3 family. It has been shown to promote cell proliferation and migration in various cancers, indicating its potential clinical significance. However, role hepatocellular carcinoma (HCC) remains largely unexplored, with limited reports available literature. AIM To investigate expression significance HCC explore tumor progression. METHODS We analyzed mRNA adjacent tissues using data from The Cancer Genome Atlas (TCGA). correlation...
ABSTRACT Human parvovirus B19 frequently causes acute and chronic arthritis in adults. The molecular mechanism of arthritis, however, remains poorly understood. We previously showed that the transmission from rheumatoid synoviocytes to monocytic cells is associated with enhanced secretion tumor necrosis factor alpha (TNF-α), which triggers inflammation, interleukin-6. To determine role production TNF-α, we focused on function its nonstructural protein, NS1, established U937 lines transduced...
MicroRNAs (MiRNAs), which regulate the gene expression leading to translational inhibition or mRNA degradation, are involved in carcinogenesis and tumor progression. Previous studies have demonstrated that miR-221 was one of most consistent overexpressed miRNAs several types cancer. However, role human liver cancer progression is not yet fully elucidated. Levels plant homeodomain finger 2 (PHF2) expressions hepatocellular carcinoma (HCC) tissues cell lines were detected using western...
Abstract Skin epidermal stem cells (EpSCs) play an important role in wound healing. Quercetin is a phytoestrogen reported to accelerate skin healing, but its effect on EpSCs unknown. In this study, we investigated the of quercetin human EpSC proliferation and explored underlying mechanisms. We found that at 0.1~1 μM significantly promoted increased number S phase. The pro-proliferative was confirmed cultured tissue. Mechanistic studies showed upregulated expressions β-catenin, c-Myc, cyclins...
Epidermal stem cells (EpSCs) play a vital role in skin wound healing through re-epithelialization. Identifying chemicals that can promote EpSC proliferation is helpful for treating wounds. This study investigates the effect of morroniside on cutaneous mice and explores underlying mechanisms. Application 10‒50 μg/mL to promotes mice.
Abstract Human parvovirus B19 (B19) often causes acute polyarthritis in adults. In this paper, we analyzed nucleotide sequences of the genome patients with rheumatoid arthritis (RA), and then introduced nonstructual protein 1 (NS1) gene into C57BL/6 mice that had a genetic origin not susceptible to arthritis. The transgenic developed no lesions spontaneously, but were type II collagen (CII)-induced NS1 was expressed synovial cells on articular histologically characteristic granulomatous...
Skin epidermal stem cells (EpSCs) play critical roles in skin homeostasis and the repair of injury. Luteolin-7-glucoside (L7G) has been reported to accelerate wound healing through its anti-inflammatory antioxidative activity. But effect on EpSCs is not clear. In present study, we examined L7G proliferation human explored mechanisms involved. MTT assay showed that promoted EpSC a dose- time-dependent manner. BrdU incorporation Ki67 immunofluorescence staining confirmed proproliferative...
Objective: To test the microRNA-181c (miR-181c) expression in tissues and plasma of gastric cancer (GC) cases, analyze any correlations, explore possibility miR-181c as a potential molecular marker for GC diagnosis. Materials Methods: Relative levels cancers from 30 patients was tested using reverse transcription-real-time fluorescent quantitation PCR compared to that samples ulcer chronic gastritis patients. Results: The level significantly higher than (P = 0.000), 0.000). We determined...
Objective To identify the computed tomographic features to differentiate gastric schwannoma from gastrointestinal stromal tumor. Methods Computed images of 103 pathologically confirmed patients with (n = 23) or tumor 80) were retrospectively studied. Sex, morphology, location, border, growth pattern, enhancement necrosis, calcification, ulceration, and perigastric lymph nodes analyzed. Age, short diameter, long degree measured. Statistical analyses performed, receiver operating...
Microsatellites, known as simple sequence repeats (SSRs), are short tandem of 1 to 6 nucleotide motifs found in all genomes, particularly eukaryotes. They widely used co-dominant markers genetic analyses and molecular breeding. Triticeae , a tribe grasses, includes major cereal crops such bread wheat, barley, rye, well abundant forage lawn playing crucial role global food production agriculture. To enhance work expedite the improvement crops, we have developed TriticeaeSSRdb, an integrated...
Abstract Integrins, a class of membrane receptors, are major players in transmitting the mechanical force across plasma membrane. We previously reported that overexpression integrin β1 subunit imposed growth inhibitory effect on hepatocellular carcinoma cell line SMMC‐7721 through transcriptional activation p21 WAF1/CIP1 gene. In this study, we further determined molecular mechanisms underlying expression induced by overexpression. report herein upregulates WAF1/Cip1 transcription...
Angiopoietin-like 4 (ANGPTL4) is a secreted metabolism-modulating glycoprotein involved in the progression of tumours, cardiovascular diseases, metabolic syndrome and infectious diseases. In this study, more CD8+ T cells were activated to be effector ANGPTL4-/- mice. Impaired growth tumours implanted 3LL, B16BL6 or MC38 reduced metastasis by B16F10 observed Bone marrow (BM) transplantation experiments displayed that deficiency ANGPTL4 either host BM promoted cell activation. However,...