A5016898440- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Ion channel regulation and function
- Cardiovascular and exercise physiology
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Coronary Interventions and Diagnostics
- Non-Invasive Vital Sign Monitoring
- Statistical and numerical algorithms
- Heart rate and cardiovascular health
- Cardiovascular Health and Risk Factors
- Natural Language Processing Techniques
- Music Therapy and Health
- Quality and Safety in Healthcare
- Topic Modeling
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Technology and Patient Monitoring
Leiden University
2007-2023
Leiden University Medical Center
2013-2023
Barts Health NHS Trust
2013
In patients with primary prevention implantable cardioverter-defibrillators (ICDs), the incidence of life-threatening ventricular arrhythmias resulting in ICD therapy is relatively low, prompting for better risk stratification. The aim this study was to assess value QRS-T angle prediction and mortality ischemic heart disease.ICD (n=412, 361 men; age, 63+/-11 years) disease a left ejection fraction < or = 40% were included. After device implantation, occurrence appropriate noted. A survival...
Serial electrocardiography aims to contribute electrocardiogram (ECG) diagnosis by comparing the ECG under consideration with a previously made in same individual. Here, we present novel algorithm construct dedicated deep-learning neural networks (NNs) that are specialized detecting newly emerging or aggravating existing cardiac pathology serial ECGs.We developed method for analysis and tested its performance detection of heart failure post-infarction patients, ischemia patients who...
Consistent improvement of image priors over the years has led to development better inverse problem solvers. Diffusion models are newcomers this arena, posing strongest known prior date. Recently, such operating in a latent space have become increasingly predominant due their efficiency. In recent works, these been applied solve problems. Working typically requires multiple applications an Autoencoder during restoration process, which leads both computational and quality challenges. work, we...
The study aimed to assess whether the 12-lead ECG-derived ventricular gradient, a vectorial representation of action potential duration heterogeneity directed toward area shortest duration, can improve ECG diagnosis chronic right (RV) pressure load. ECGs from 72 pulmonary arterial hypertension patients recorded <30 days before onset therapy were compared with matched healthy control subjects (n = 144). Conventional criteria for increased RV load gradient. In 38 cardiac magnetic resonance...
T‐wave alternans (TWA), an electrophysiologic phenomenon associated with ventricular arrhythmias, is usually detected from selected ECG leads. TWA amplitude measured in the 12‐standard and 3‐orthogonal (vectorcardiographic) leads were compared here to identify which lead system yields a more adequate detection of as noninvasive marker for cardiac vulnerability arrhythmias. Our adaptive match filter (AMF) was applied exercise tracings 58 patients implanted defibrillator, 29 had tachycardia or...
Cardiac sarcoidosis (CS) with right ventricular (RV) involvement can mimic arrhythmogenic cardiomyopathy (ARVC). Histopathological differences may result in disease-specific RV activation patterns detectable on the 12-lead electrocardiogram. Dominant subepicardial scar ARVC leads to delayed of areas reduced voltages, translating into terminal delay and occasionally (epsilon) waves a small amplitude. Conversely, patchy transmural CS lead conduction block therefore late activated preserved...
Background: Spontaneous nonsustained ventricular tachycardia (NSVT) on Holter, VT inducibility during electrophysiology study, and late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) have been associated with sustained arrhythmias (SVAs) in nonischemic dilated cardiomyopathy (DCM). This study aimed to analyze whether these parameters carry independent prognostic value for spontaneous SVA DCM. Methods: Between 2011 2018, patients the DCM clinical spectrum documented SVA,...
Patients with repaired tetralogy of Fallot (rTOF) have an increased risk ventricular tachycardia (VT), slow conducting anatomical isthmus (SCAI) 3 as dominant VT substrate. In patients right bundle branch block (RBBB), SCAI leads to local activation delay a shift terminal RV towards the lateral outflow tract which may be detected by QRS vector changes on sinus rhythm electrocardiogram (ECG).Consecutive rTOF aged ≥16 years RBBB who underwent electroanatomical mapping at our institution...
There is no consensus about the time instant relative to J point where ST deviation has be measured for detection of acute ischemia in ECG.We analyzed 53 ECGs, recorded preceding emergency catheterization coronary syndrome patients with a completely occluded culprit artery (cases), and 88 control ECGs cardiology outpatient clinic. ECG-amplitude measurements were made every 10 ms, between 20 ms before till 80 after point. STEMI-detection algorithms varied from traditional STEMI criterion...
BackgroundSeveral studies have reported changes in electrocardiographic variables after atrial septal defect (ASD) closure. However no temporal electro-and vectorcardiographic been described from acute to long-term follow-up at different ages. We aimed study electrical remodeling percutaneous ASD closure pediatric and adult patients.MethodsECGs of 69 children 75 adults (median age 6 [IQR 4–11] years 45 33–54] years, respectively) were retrospectively selected before (1–7 days), intermediate...
The power of exercise‐induced T‐wave alternans (TWA) to predict the occurrence ventricular arrhythmias was evaluated in 67 patients with an implanted cardiac defibrillator (ICD). During 4‐year follow‐up, electrocardiographic (ECG) tracings were recorded a bicycle ergometer test increasing workload ranging from zero (NoWL) patient′s maximal capacity (MaxWL). After classified as either ICD_Cases (n = 29), if developed tachycardia/fibrillation, or ICD_Controls 38). TWA quantified using our...
In a previous study we demonstrated that the institution of biventricular pacing in chronic heart failure (CHF) acutely facilitates arterial baroreflex. The baroreflex has important prognostic value CHF. We hypothesized acute response sensitivity (BRS) after cardiac resynchronization therapy (CRT) predictive for midterm response. One day implantation CRT device 33 CHF patients (27 male/6 female; age, 66.5 +/- 9.5 yr; left ventricular ejection fraction, 28 7%) measured noninvasive BRS and...