A5087750989- Attention Deficit Hyperactivity Disorder
- Prenatal Substance Exposure Effects
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Healthcare Technology and Patient Monitoring
- Vascular Anomalies and Treatments
- Anesthesia and Neurotoxicity Research
- Neuroendocrine Tumor Research Advances
- Iron Metabolism and Disorders
- Inhalation and Respiratory Drug Delivery
- Pediatric Hepatobiliary Diseases and Treatments
- Respiratory and Cough-Related Research
- Neonatal Health and Biochemistry
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Nitric Oxide and Endothelin Effects
- Hemoglobinopathies and Related Disorders
- Tracheal and airway disorders
- Children's Physical and Motor Development
- Patient Safety and Medication Errors
- Epilepsy research and treatment
- Behavioral and Psychological Studies
Hospital for Sick Children
1994-2004
University of Toronto
1998-2004
SickKids Foundation
1999
ContextNumerous women of childbearing age are exposed occupationally to organic solvents. Previous retrospective studies have reported conflicting results regarding teratogenic risk.ObjectiveTo evaluate pregnancy and fetal outcome following maternal occupational exposure solvents.DesignA prospective, observational, controlled study.SettingAn antenatal counseling service in Toronto, Ontario.PatientsOne hundred twenty-five pregnant who were solvents seen during the first trimester between 1987...
We reviewed the linear growth and plate morphology in all children with homozygous beta thalassemia followed Toronto, for whom monthly height percentiles were available before, a 36-month period after, initiation of nightly subcutaneous deferoxamine therapy. All patients less than 7 years age when begun on deferoxamine, had received minimum 36 months. Marked abnormalities metaphyseal readily observed distal ulnar, radial, tibial metaphyses 11 37 significant decline mean percentile was also...
<h3>Abstract</h3> <b>Objectives</b> To characterise the incidence and nature of medication errors during paediatric resuscitations. <b>Design</b> A prospective observational study simulated emergencies. <b>Setting</b> Emergency department a tertiary hospital. <b>Participants</b> Teams that included clinician who commonly leads "real" resuscitations, at least two assisting physicians, or three nurses. <b>Interventions</b> The teams conducted eight mock including ordering medications....
Ifosfamide is widely used in the treatment of pediatric solid tumors. Its main adverse effects are various forms renal tubular and glomerular damage. The authors sought to determine factors that predict risk for development severity ifosfamide-induced nephrotoxicity children examine long-term outcome this complication. A total 174 who had received ifosfamide cancers were studied. Nephrotoxicity was assessed by laboratory markers function a grading score (none, mild, moderate, severe)....
<h3>Background</h3> Many women of reproductive age are employed in industries involving exposure to organic solvents. Animal toxicological studies and human case reports demonstrate that high solvents causes neurodevelopmental toxicity exposed offspring. Data from occupationally their children few. <h3>Objective</h3> To compare the cognitive, language, motor performance behavioral achievements whose mothers were during pregnancy with those a matched unexposed control group....
The calcium antagonist amlodipine may have the potential for expanded use in children owing to its physiochemistry and pharmacokinetic profile that facilitates once-daily dosing a liquid formulation. Its safety efficacy not been previously evaluated children. A retrospective analysis of 15 pediatric bone marrow transplant patients who had incorporated into their antihypertensive drug regimen reveals significantly lower blood pressure as compared with baseline therapy (123.5 ±2.1 mmHg 117.2...
Objective: To evaluate the real-world efficacy, safety, and functional outcomes of PRC-063 (multilayer-release methylphenidate) versus lisdexamfetamine (LDX) in ADHD subjects a phase IV, open-label study. Method: The primary endpoint was change ADHD-DSM-5 Rating Scale (ADHD-5-RS) total score from baseline to Month 4. Secondary endpoints included non-inferiority comparison between LDX measures functioning evening behavior. Results: One hundred forty-three pediatric 112 adult were enrolled....
Copy number variations (CNVs) involving the JAG1 gene are rare and infrequently reported in scientific literature. Recently, a generally healthy young patient presenting with history of behavioural concerns was referred to us. Herein, we discuss patient, 7-year-old female possessing 0.797 Mb microduplication within short arm chromosome 20 at band 12.2. The generates considerable curiosity due rarity her case, which includes de novo partial duplication gene. exhibits wide range symptoms...
Depressive disorders are characterized by sadness, loss of interest, feelings guilt or low self-worth, disturbed sleep appetite, tiredness, and poor concentration. Mental disorders, including depression, prevalent globally, particularly in prison populations, where conditions exacerbate existing issues. This study aims to assess the level depression among convicted male prisoners aged 18-50 years Attock using Beck Depression Inventory (BDI).The primary objective is find out prevalence...