A5048580584- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Urologic and reproductive health conditions
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Dietary Effects on Health
- Tissue Engineering and Regenerative Medicine
- Comparative Animal Anatomy Studies
- Effects and risks of endocrine disrupting chemicals
- Cancer Cells and Metastasis
- Congenital gastrointestinal and neural anomalies
- Extracellular vesicles in disease
- Selenium in Biological Systems
- Estrogen and related hormone effects
- Bone and Dental Protein Studies
- Nuclear Structure and Function
- RNA Interference and Gene Delivery
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mesenchymal stem cell research
Universidade Estadual de Campinas (UNICAMP)
2016-2024
Universidade Estadual Paulista (Unesp)
2014-2019
Abstract Telocytes are CD34‐positive interstitial cells, known to exert several functions, one of which is a role in tissue organisation, previously demonstrated by telocytes the myocardium. The existence prostate has recently been reported, however, there lack information regarding function these cells tissue, and possible prostatic development. This study used immunofluorescence techniques culture determine relationship between morphogenesis. Furthermore, immunofluorescent labelling was...
The prostate is a mammalian gland that shows complex process of organogenesis. Here, morphological study to characterize the organogenesis ventral lobe in male gerbils was conducted. urogenital sinus (UGS) dissected out and processed for paraffin embedding. Histological sections were subjected cytochemical, immunofluorescence, immunohistochemical, three-dimensional reconstruction techniques. We found first buds emerged from urethral epithelium between days 20 21 prenatal life, reaching...
Telocytes are CD34-positive cells with a fusiform cell body and long, thin cytoplasmic projections called telopodes. These were detected in the stroma of various organs, including prostate. The prostate is complex gland capable undergoing involution due to low testosterone levels; this condition can be reversed replacement. Telocyte function mature remains dermined, it not known whether telocytes take place tissue remodeling during regrowth. present study employed structural, ultrastructural...
Abstract Telocytes are interstitial cells present in the stroma of several organs, including prostate. There is evidence that these during prostate alveologenesis, which play a relevant role, but there no information about presence and possible changes telocytes aging. Throughout aging, undergoes spontaneous pro-pathogenic. Our study used histochemistry, 3D reconstructions, ultrastructure immunofluorescence to compare adult with senile Mongolian gerbil, order investigate senescence role for...
The development of the prostate in male rodents, which involves complex epithelial–mesenchymal interactions between urogenital sinus epithelium (UGE) and mesenchyme (UGM), has been deeply studied. In females, however, this process is not very clear. study, postnatal female Mongolian gerbils employing three-dimensional (3D) reconstructions, histochemical, immunohistochemical techniques was characterized. It observed that prostatic branching differentiation females induced by a single...
ABSTRACT The development of the prostate gland in females has not yet been clearly elucidated, and sexual dimorphism associated with such general is far from being understood. In present study, we used tridimensional (3D) reconstructions histochemical immunohistochemical techniques to describe its causes early postnatal male female Mongolian gerbils ( Meriones unguiculatus ). We observed that was smaller, had fewer branches throughout development, underwent differentiation earlier than...
Abstract Telocytes are cells present in the stroma of various tissues including prostate. The detection telocytes is still very much dependent on obtaining ultrastructural data that show presence telopodes, which cytoplasmic projections alternate between dilated regions, podoms, and thin segments, podomers. These structures distinctive characteristics telocytes. Thus, vitro assays important for study telocytes, more easily identified culture, also enables experimental manipulation these...
Abstract The postlactational involution of the mammary gland is a complex process. It involves collapse alveoli and remodeling extracellular matrix, which in turn implies set interrelations between epithelial, stromal, matrix elements. telocytes, new type CD34‐positive stromal cell that differs from fibroblasts morphological terms gene expression, were detected stroma several tissues, including gland; however, their function remains elusive. present study employed three‐dimensional...
Abstract The prostate is not an organ exclusive to the male. It also found in females of several species, including humans, which part Skene gland homologous male prostate. Evidence accumulating that changes stroma are central tumorigenesis. Equally, telocytes, a recently discovered type interstitial cell, essential for maintenance stromal organization. However, it still uncertain whether there telocytes female and if they play role present study used ultrastructural immunofluorescence...
The effects of intrauterine exposure to 17β-oestradiol (E2) are well studied for the male prostate and there accumulating evidences that high dosages leads a hypomorphic development. However, is lack information about E2 in rodent females, such research becomes relevant view presence functional proportion women, morphophysiological similarities between female rodents women. This study uses histochemical, immunohistochemical, immunofluorescence three-dimensional (3D) reconstruction techniques...
Finasteride is a drug that widely used in the treatment of benign prostatic hyperplasia, hair loss and even as chemotherapeutic agent adenocarcinoma. However, its use known to cause several side effects adults it can also changes embryonic development male prostate, which for concern given possibility accumulation finasteride environment. Nevertheless, no studies have investigated on prostate females, occurs species mammals. To evaluate intrauterine exposure (500μgkg-1 day-1) postnatal...
The prostate is an accessory reproductive gland that sensitive to the action of exogenous compounds known as endocrine disrupters alter normal hormonal function. Finasteride a widely used chemical acts inhibit conversion testosterone in its most active form, dihydrotestosterone. It intrauterine exposure finasteride causes changes male even at low dosages; however, it not whether these dosages are capable causing female prostate, which present large number mammalian species, including humans....
The presence of the prostate in female mammals has long been known. However, pieces information related to its development are still lacking. aim this study was explore budding dynamic during initial gerbils. Pregnant females were timed, fetuses euthanized, and urogenital sinus dissected out between embryonic days 20 24 (E20-E24 groups). Newborn pups (1-day-old; P1 group) underwent same procedures. based on epithelial buds which arose far from paraurethral mesenchyme (PAM). reached PAM at...
Abstract The development and maintenance of prostate function depend on a fine balance between oestrogen androgen levels. Finasteride inhibits 5α‐reductase, which is responsible for the conversion testosterone into its most active form, dihydrotestosterone. Enzymes that metabolize these hormones have highly relevant role in both normal metabolism occurrence pathological conditions. There are few studies impact finasteride male fewer female possible intersexual differences. Therefore, we...