A5079855316- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Climate change and permafrost
- Graphene and Nanomaterials Applications
- CRISPR and Genetic Engineering
- Dendrimers and Hyperbranched Polymers
- Nanoplatforms for cancer theranostics
- Smart Materials for Construction
- Maritime Transport Emissions and Efficiency
- Gold and Silver Nanoparticles Synthesis and Applications
- Cryospheric studies and observations
- Geotechnical Engineering and Underground Structures
- Ship Hydrodynamics and Maneuverability
- Aquatic Ecosystems and Biodiversity
- Manufacturing Process and Optimization
- Photochromic and Fluorescence Chemistry
- Composite Structure Analysis and Optimization
- Supramolecular Self-Assembly in Materials
- Autoimmune and Inflammatory Disorders Research
- Fluid Dynamics Simulations and Interactions
- Arctic and Antarctic ice dynamics
- Robotic Locomotion and Control
- Inflammasome and immune disorders
- Photodynamic Therapy Research Studies
South China University of Technology
2019-2024
East China Normal University
2019-2024
Wuhan University of Technology
2022-2023
Shijiazhuang Tiedao University
2020
China Coal Research Institute (China)
2020
Tiandi Science & Technology (China)
2020
Sichuan University
2017
Qilu University of Technology
2016
Zhejiang University
2014
Southeast University
2007
We report the rational design of a polymer with unprecedented and robust efficiency for cytosolic delivery native proteins.
Developing protein drugs that can target intracellular sites remains a challenge due to their inadequate membrane permeability. Efficient carriers for cytosolic delivery are required protein-based drugs, cancer vaccines, and CRISPR-Cas9 gene therapies. Here, we report screening process identify highly efficient materials from library of dual-functionalized polymers bearing both boronate lipoic acid moieties. Both ligands were found be crucial binding, endosomal escape, release. Polymers with...
We achieve off-on control of enzyme activity via photothermal-induced phase transition polymers coated on the surface.
Abstract RNA interference with the ability to specifically silence target genes has shown great potential treat various diseases. The primary challenge for is effectively and selectively deliver genetic materials such as small interfering (siRNA) targeted tissues cells in vivo . Numerous efforts have been made overcome extracellular intracellular barriers during siRNA delivery. In this review, we focused on most recent advances design of functional polymers achieve efficient delivery via...
Polymer-mediated intracellular protein delivery systems are important for the development of protein-based biotechnologies and therapeutics. However, cargo proteins in presence serum remains challenging due to competitive binding with polymers. Here, we reported a dendrimer engineered high density 4-diethylaminophenyl groups on surface address this issue. The showed pH-responsive phase-transition behavior could assemble into stable nanoparticles solutions. It efficiently delivered living...
Abstract The development of reactive oxygen species (ROS)-responsive drug delivery and release has gradually attracted much attention in recent years as a promising therapeutic strategy. Singlet ( 1 O 2 ) the major ROS is widely used photodynamic therapy (PDT) cancer. In present study, we introduce combined treatment using ROS-sensitive thioketal (TK) linkage linker between upconversion nanoparticles (UNs)-based PDT doxorubicin (DOX)-based chemotherapy. UNs can not only play role PDT, but...
Abstract Numerous nanomedicines have been developed to improve the efficiency and safety of conventional anticancer drugs; however, complexities in carrier materials functional integration make it challenging promote these candidates for clinical translation. In this study, a facile method prepare carrier‐free nanodrug with inherent bone targeting osteoclastogenesis inhibition capabilities is reported. Phytic acid, naturally occurring nontoxic product, reacted cisplatin form uniform...
Intracellular protein delivery has attracted increasing attentions in biomedical applications. However, current systems usually have poor serum stability due to the competitive binding of proteins polymers during delivery. Here, we report a reversible cross-linking strategy improve for robust intracellular In proposed system, nanoparticles are assembled by cargo and cationic further stabilized glutathione-cleavable traceless cross-linker. The cross-linked show high efficient cell...
Boronic acid-engineered gold nanoparticles for effective cytosolic protein delivery with the help of hypertonicity.
Determining the development of artificial frozen walls by present methods is challenging where substantial seepage occurs because fixed monitoring points only indicate physical properties in small areas. Here we use ultrasonic acoustic to determine between two freezing pipes during freezing. Sensitivity analysis indicates that wave velocity sensitive properties, and sensitivity rank water content > temperature density. The attenuation coefficient has a low parameters, whereas dominant...
Abstract Determining the freezing state and frozen section thickness is fundamental to assessing development of artificial walls but commonly difficult or inaccurate because a limited number fixed position thermometer holes under complex field conditions. We report novel experimental design that measures soil temperature, water content, ultrasonic properties monitor movement cryofront (0°C isotherm), migration, acoustic parameters during progressive upward fine sand laboratory Ultrasonic...
The importance of Maritime transportation energy conservation and emission reduction has been increasingly recognized. A novel bio-inspired method utilizing the favorable hydrodynamic interaction in ship convoys is introduced this paper to achieve an bonus for whole formation system or/and members. Firstly, grid convergence analysis virtual captive model tests are conducted verify discretization validate adopted numerical method. Following this, simulations based on STAR CCM+ performed...
Modification with benzenesulphonate on a phase-transition polymer can improve the protein delivery efficacy, reduce cytotoxicity and adsorption.
Length–weight relationships (LWRs) are presented for 11 species [Acrossocheilus monticola (Günther, 1888), Squalidus wolterstorffi (Regan, 1908), Sinibrama taeniatus (Nichols, 1941), Gnathopogon herzensteini 1896), Rhynchocypris oxycephalus (Sauvage & Dabry de Thiersant, 1874), Rhodeus lighti (Wu, 1931), Platysmacheilus nudiventris Luo, Le Chen, 1977, Hemibagrus macropterus Bleeker, 1870, Glyptothorax fokiensis (Rendahl, 1925), Liobagrus marginatoides 1930), Sinogastromyzon szechuanensis...
Abstract Introduction: The ratio of poor sleep quality and life is one the most common complaints among college students, medical students had a higher than ordinary students. However, research on living Inner Mongolian was scarce. primary goals this study were to look into incidence symptoms many methods action diet involved in Mongolia China. Methods A cross-sectional done 1181 university ages 16 27. They evaluated using an anonymous, self-administered questionnaire demographic factors...
Being one kind of functional nanomaterials importance, magnetic nanomaterial with various excellent properties could be used in many fields, such as information, mechanics, and biomedicine. The main possible applications biomedicine will described the focus on earlier diagnosis effective treatment tumors. Also our recent interrelated results are included.