A5080750320- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Radiation Therapy and Dosimetry
- High-pressure geophysics and materials
- Laser-Matter Interactions and Applications
- Advanced Radiotherapy Techniques
- Ion-surface interactions and analysis
- Effects of Radiation Exposure
- Advanced Drug Delivery Systems
- Gamma-ray bursts and supernovae
- Astro and Planetary Science
- Pancreatic function and diabetes
- Atomic and Molecular Physics
- Medical Imaging Techniques and Applications
- Electrohydrodynamics and Fluid Dynamics
- Nuclear Physics and Applications
Queen's University Belfast
2014-2024
Massachusetts Institute of Technology
2024
École Polytechnique
2017
Laboratoire pour l'utilisation des lasers intenses
2017
Centre National de la Recherche Scientifique
2017
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2017
Université Grenoble Alpes
2016
National Physical Laboratory
2016
Centre Hospitalier Universitaire de Grenoble
2016
Needle-based injections currently enable the administration of a wide range biomacromolecule therapies across body, including gastrointestinal tract1–3, through recent developments in ingestible robotic devices4–7. However, needles generally require training, sharps management and disposal, pose challenges for autonomous systems. Here, inspired by jetting systems cephalopods, we have developed evaluated microjet delivery that can deliver jets axial radial directions into tissue, making them...
Protontherapy has emerged as more effective in the treatment of certain tumors than photon based therapies. However, significant capital and operational costs make protontherapy less accessible. This stimulated interest alternative proton delivery approaches, this context use laser-based technologies for generation ultra-high dose rate ion beams been proposed a prospective route. A better understanding radiobiological effects at dose-rates is important any future clinical adoption...
Abstract Interaction of intense lasers with nm thick targets provides an attractive regime for the acceleration ions all types. Acceleration heavy however is undermined in presence low charge contaminant species due to their higher charge-to-mass ratio. Here we show narrow-band very Au from ~15 foils driven by a sub-Petawatt laser, spectral peaks 1.5 ± 0.5 GeV at fluxes on order 10 12 particles per steradian. 3D and 2D particle-in-cell simulations complex interplay between different...
Accelerated proton beams have become increasingly common for treating cancer. The need cost and size reduction of particle accelerating machines has led to the pioneering investigation optical ion acceleration techniques based on laser-plasma interactions as a possible alternative. Laser-matter interaction can produce extremely pulsed bursts ultra-high dose rates (⩾ 109 Gy/s), largely exceeding those currently used in conventional therapy. Since biological effects ionizing radiation are...
A modification to the standard Thomson parabola spectrometer is discussed, which designed measure high energy (tens of MeV/nucleon), broad bandwidth spectra multi-species ions accelerated by intense laser plasma interactions. It proposed implement a pair extended, trapezoidal shaped electric plates, will not only resolve ion traces at energies, but also retain lower part spectrum. While longer (along axis undeflected beam direction) plate design provides effective charge state separation end...
Abstract The characteristics of laser driven proton beams can be efficiently controlled and optimised by employing a recently developed helical coil technique, which exploits the transient self-charging solid targets irradiated intense pulses. Here we demonstrate well collimated (<1° divergence) narrow bandwidth (~10% energy spread) beamlet ~10 7 particles at 10 ± 0.5 MeV obtained irradiating with few joules, sub-ps pulses an intensity ~2 × 19 W cm −2 . experimental data are in good...
Ongoing developments in laser-driven ion acceleration warrant appropriate modifications to the standard Thomson Parabola Spectrometer (TPS) arrangement order match diagnostic requirements associated particular and distinctive properties of laser-accelerated beams. Here we present an overview recent by our group TPS aimed enhance capability diagnosing multi-species high-energy In facilitate discrimination between ions with same Z/A, a recursive differential filtering technique was implemented...
Abstract Developing compact ion accelerators using intense lasers is a very active area of research, motivated by strong applicative potential in science, industry and healthcare. However, proposed applications medical therapy, as well nuclear particle physics demand strict control energy, the angular spectral distribution beam, beyond intrinsic limitations several acceleration mechanisms explored so far. Here we report on production highly collimated ( $$\sim 0.2^{\circ }$$ <mml:math...
Abstract Background There is currently significant interest in assessing the role of oxygen radiobiological effects at ultra-high dose rates. Oxygen modulation postulated to play a enhanced sparing effect observed FLASH radiotherapy, where particles are delivered 40–1000 Gy/s. Furthermore, development laser-driven accelerators now enables radiobiology experiments extreme regimes rates can exceed 10 9 Gy/s, and predicted depletion on cellular response be tested. Access appropriate...
Image plates (IPs) are a popular detector in the field of laser driven ion acceleration, owing to their high dynamic range and reusability. An absolute calibration these detectors laser-driven protons routinely produced tens MeV energy is, therefore, essential. In this paper, response Fujifilm BAS-TR IPs 1–40 is calibrated by employing resolution Thomson parabola spectrometers conjunction with CR-39 nuclear track determine proton numbers. While was placed front image plate for lower protons,...
The response of the BAS-TR image plate (IP) was absolutely calibrated using a CR-39 track detector for high linear energy transfer Au ions up to ∼1.6 GeV (8.2 MeV/nucleon), accelerated by high-power lasers. calibration carried out employing high-resolution Thomson parabola spectrometer, which allowed resolving with closely spaced ionization states 58+. A function obtained fitting photo-stimulated luminescence per ion different energies, is broadly in agreement that expected from stopping...
Purpose: This study introduces an advanced method to evaluate and extent the adjustment of prescribed dose maintain same clinical results, when changing calculation algorithm type (a), i.e density correction more recently (b) algorithm, AAA.Material methods: 10 cases with lung cancer were studied.For each case, 3 treatment plans generated.Plan 1 was generated using (a) Plan 2 algorithm.In plan calculated monitor units from as input.A global analysis based on 2D 3D gamma (γ) made under /...
Proton beams driven by the target normal sheath acceleration mechanism exhibit large divergence and a broad energy distribution with low particle number at high energy. Such undesirable characteristics of beam can be controlled optimised employing recently developed helical coil technique, which exploits transient self-charging solid targets irradiated intense laser pulses. Highly chromatic focusing broadband proton was achieved this technique TARANIS system, where selected slice tuned...
Abstract BackgroundThere is currently significant interest in assessing the role of oxygen radiobiological effects at ultra-high dose rates. Oxygen modulation postulated to play a enhanced sparing effect observed FLASH radiotherapy, where particles are delivered 40-1000 Gy/s. Furthermore, development laser-driven accelerators now enables radiobiology experiments extreme regimes rates can exceed 10^9 Gy/s, and predicted depletion on cellular response be tested. Access appropriate experimental...