A5100343677- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Maternal and fetal healthcare
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Cancer Risks and Factors
- Ectopic Pregnancy Diagnosis and Management
- Renal and related cancers
- Urological Disorders and Treatments
- Pregnancy-related medical research
- Power Quality and Harmonics
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Quantum chaos and dynamical systems
- Childhood Cancer Survivors' Quality of Life
- Nonlinear Dynamics and Pattern Formation
- Demographic Trends and Gender Preferences
- Ovarian cancer diagnosis and treatment
- Sentiment Analysis and Opinion Mining
- Complex Network Analysis Techniques
- Evaluation Methods in Various Fields
- Advanced Text Analysis Techniques
- Sex work and related issues
- Effects and risks of endocrine disrupting chemicals
- Gestational Trophoblastic Disease Studies
Huazhong University of Science and Technology
2004-2024
Tongji Hospital
2013-2023
The initiation of primordial follicle development is essential for female fertility, but the signals that trigger this process are poorly understood. Given potentially important roles microRNAs (miRNAs) in ovary, we aimed to study expression patterns and regulatory functions miRNAs during development. Expression miRNA neonatal mouse ovary were profiled by microarray, 24 whose abundances differed significantly between ovaries from 3- 5-day-old mice identified. Pathway enrichment analysis...
microRNAs (miRNAs/miRs) may have a crucial function in tumor metastasis through the regulation of plethora signaling pathways. Increasing evidence has shown that miR‑199a is important regulating ovarian cancer, although precise biological unclear at present. In current study, it was observed expression levels were higher OV2008 cells compared with C13* cells. However, lower mammalian target rapamycin (mTOR) protein detected by western blotting The increased using mimics and mTOR to decrease....
In order to overcome the essential difficulties in conventional nonlinear control with iteratively adjusting multiple parameters, a novel method for designing multidirection multibutterfly chaotic attractors (MDMBCAs) without reconstructing functions is proposed. By using unified pulse modified Lorenz system, family of complete can be produced, including 1-D, 2-D, and 3-D attractors. Theoretical analysis numerical simulations show that arbitrary MDMBCA all generated by conducting...
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare that characterized by congenital aplasia of the uterus and upper portion (2/3) vagina. Previous attempts to identify causal mutations MRKH have primarily resulted in negative outcomes. We investigated whether these reported variants are associated with (types I II) relatively large sample size Chinese Han patients, any gene-gene epistatic interactions exist among variants.This study included 182 unrelated women (155 type 27 228...
Background: To find a suitable indicator in selecting appropriate patients with cesarean scar pregnancy (CSP) for treatment ultrasound-guided suction curettage alone.Methods: A retrospective review of all women CSP treated at the Tongji Hospital, Wuhan, China, between 1 January 2013 and 31 December 2015 was conducted. The were grouped according to following management options: only (Group 1); combination other therapeutic options 2). clinical characteristics outcomes analyzed.Results: Of 174...
To evaluate the effects of systemic methotrexate in cesarean scar pregnancy (CSP) patients treated with ultrasound-guided suction curettage. A retrospective review all women presenting CSP curettage at Tongji Hospital, Wuhan, China, between January 1, 2013 and December 31, 2015, was conducted. Patients were grouped into those not before (group 1), by intramuscular injection 2) intravenous 3). The clinical characteristics outcomes analyzed. Among 107 patients, 47 curettage, 46 had...
Abstract Our understanding of how aging affects the cellular and molecular components human ovary contributes to age-related fertility decline is still limited. Here, we link single-cell RNA sequencing spatial transcriptomics characterize ovarian aging. Changes signatures eight types cells during were defined. We combined single cell with their location information divide granulosa into three subtypes theca & stroma five subtypes. Further analysis revealed increased senescence age...
Our previous study demonstrated that ovarian wild-type P53-induced phosphatase 1 (WIP1) expression decreased with age. We hypothesized WIP1 activity was related to aging. The role of in regulating aging and its mechanisms remain be elucidated. Adult female mice or without inhibitor (GSK2830371) treatment were divided into three groups (Veh, GSK-7.5, GSK-15) evaluate the effect on endocrine reproductive function reserve. In vitro follicle culture primary granulosa cell applied explore...
Abstract Background With the significant improvement of cure rate and survival cancer patients, survivors need to face quality life problems, such as decline in reproductive system development, ovarian reserves function, even fertility loss early menopause. These problems are often highly associated with chemotherapy-induced damage course treatment. However, there no ideal treatment strategies at present. In our attempt develop reagents approaches for delaying aging protecting injury, we...