A5069440561- Magnetic Properties of Alloys
- Nanoparticle-Based Drug Delivery
- Magnetic Properties and Applications
- Magnetic properties of thin films
- Hydrogen Storage and Materials
- Metallic Glasses and Amorphous Alloys
- Metallurgical and Alloy Processes
- Magnetic and Electromagnetic Effects
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Magnetic Properties and Synthesis of Ferrites
- Nanoplatforms for cancer theranostics
- Ear Surgery and Otitis Media
- Advanced Polymer Synthesis and Characterization
- Superconducting Materials and Applications
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Electromagnetic wave absorption materials
- Silk-based biomaterials and applications
- Dendrimers and Hyperbranched Polymers
- Induction Heating and Inverter Technology
- Fiber-reinforced polymer composites
- Rare-earth and actinide compounds
- Hydrogels: synthesis, properties, applications
The University of Tokyo
2015-2025
Innovation Center of NanoMedicine
2020-2024
University of Tokyo Hospital
2023
Kisarazu Hospital
2017
Mitsubishi Materials (Japan)
1999-2014
Central Research Institute
2001-2003
Musashi University
1997
Takeda (Japan)
1994-1996
Toshiba (Japan)
1989
Betacellulin, a member of the epidermal growth factor family, has been identified in conditioned medium cell lines derived from mouse pancreatic beta tumors. Betacellulin is 32-kilodalton glycoprotein that appears to be processed larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain betacellulin 50 percent sequence similarity with rat transforming alpha. potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Treatment of immunologically cold tumors is a major challenge for immune checkpoint inhibitors (ICIs). Interleukin 12 (IL-12) can invigorate ICIs against by establishing robust antitumor immunity. However, its toxicity and systemic induction counteracting immunosuppressive signals have hindered translation. Here, IL-12 activity spatiotemporally controlled safely boosting efficacy without the stimulation interfering responses generating nanocytokine that remains inactive at physiological pH,...
Gold-nanoparticle-incorporated molecularly imprinted nanogels acquire stealth capabilities in vivo through protein corona regulation using intrinsic dysopsonic proteins. The composite can be used radiation therapy to treat mouse pancreatic cancer.
Abstract Protein drugs have great potential as targeted therapies, yet their application suffers from several drawbacks, such instability, short half‐life, and adverse immune responses. Thus, protein delivery approaches based on stimuli‐responsive nanocarriers can provide effective strategies for selectively enhancing the availability activation of proteins in tissues. Herein, polymeric micelles with ability encapsulating are developed via concurrent ion complexation pH‐cleavable covalent...
Bone marrow (BM) has roles in health and disease, so systemically administered nanocarriers (NCs) targeting or avoiding BM are desirable. While the hydrodynamic diameter of NCs can be tuned to target avoid various organs, size dependence extravasation from vessels is unknown. To clarify passive transvascular transport BM, we performed vessel permeability measurements murine calvaria using confocal fluorescent microscopy with fluorescently labeled dextrans, albumin, polymeric micelles as...
MgO insulation coating with thickness of ca. 50nm was evaporated on the surface iron powder and fabricated soft magnetic composite(SMC) low loss. The had greater heat resistance than conventional phosphate coating, which enabled stress relieving annealing at higher temperature (600C). Electrical properties SMC examined. electrical resistivity annealed 700C 21μΩm. loss 50Hz for Bm = 1.5T 5.34W, 40% same level laminated steel plate (t0.35). These results show that has enough adhesiveness to obtain
Aberrant sialylation of cancer cells is emerging as an attractive method for generating effective antitumor strategies. However, sialic acid (SA) also present in healthy tissues, systems targeting SA tumors must be strategically designed to specifically activated intratumoral environment while avoiding systemic interaction. Phenylboronic (PBA) and its derivatives have shown potential developing such smart ligands based on triggered binding at pH. Because the affinity PBAs against can...
Regulation of nanomaterial-cell interaction is an important requisite for a variety biomedical applications such as drug delivery systems and theranostics. Here, we demonstrate the regulation using oriented adsorption intrinsic immunoglobulin G (IgG) on molecularly imprinted polymer nanogels (MIP-NGs) capable recognizing fragment crystallizable (Fc) domain IgG. The unique recognition property resulted in suppression immune response Fc receptor-possessing macrophages natural killer cells due...
Persistent postural-perceptual dizziness (PPPD) is induced by preceding conditions that cause balance disorders. To investigate the association between vestibular function and disorders in PPPD patients, a retrospective chart review was performed. Vestibular 55 patients measured using caloric test, cervical evoked myogenic potential testing to air-conducted sound (ACS cVEMP), ocular bone-conducted vibration (BCV oVEMP), video head impulse (vHIT). Patients were classified according type of...
Lipid nanoparticles (LNPs) exhibit high potential as carriers of messenger RNA (mRNA). However, the arduous preparation process mRNA-loaded LNPs remains a huge obstacle for their widespread clinical application. Herein, we tackled this issue by mRNA PEGylation through hybridization with polyethylene glycol (PEG)-conjugated oligonucleotides (PEG-OligoRNAs). Importantly, translational activity was preserved even after 20 PEG-OligoRNAs per mRNA. The straightforward mixing PEGylated...
Abstract Dynamic bursting in tumor vasculature has recently sparked interest as a novel particle transportation route for drug delivery. These bursts facilitate the transport of sub‐100 nm nanoparticles into tumors, though their contribution on access other blood‐borne particles remains unknown. To evaluate versatility this phenomenon, vivo kinetics variety intravenously injected and penetration xenografts allografts are compared. Dextran, polymeric micelles, liposomes, vesicles with...
Assessment of drug activation and subsequent interaction with targets in living tissues could guide nanomedicine design, but technologies enabling insight into how a reaches binds its target are limited. We show that Hoechst-based reporter system can monitor release engagement from nanoparticle delivery vitro vivo, elucidating differences target-bound distribution related to drug-linker properties. Drug is defined as chemical detachment or binding subcellular target, which the case Hoechst...
The hydrogenation-decomposition-desorption-recombination (HDDR) process is a unique method to produce anisotropic Nd/sub 2/Fe/sub 14/B-based magnet powder for bonded application. In this study, we studied the effect of appending intermediate Ar (IA) treatment, i.e., hydrogenated materials are annealed under an atmosphere before evacuation treatment in HDDR process, on magnetic properties powder. It was found that IA very effective enhance anisotropy optimum made from processed 12.6/Fe/sub...
Block copolymers composed of poly(ethylene glycol) (PEG) and poly(amino acids) (PAA) segments have shown exceptional features for developing biocompatible nanostructures. While the conventional methods synthesizing PEG–PAA provide excellent control degree polymerization polydispersity, these protocols involve several steps, which increase time costs, reduce number possible block copolymer designs. In this study, we developed a one-pot synthetic method by doing sequential ring-opening...
In this article, we aim to enlighten practitioners and patients involved with acupressure beads contribute their safer use by reporting a unique case of insidious intrusion an bead into the eustachian tube. A metallic object was found in tube patient while conducting magnetic resonance imaging (MRI) examination. The later confirmed be auricular bead, successfully removed performing tympanoplasty canal wall down mastoidectomy. assumed have passed through existing perforation tympanic...
Multi-arm star-shaped block copolymers with precisely tuned nano-architectures are promising candidates for drug delivery. Herein, we developed 4- and 6-arm consisting of poly(furfuryl glycidol) (PFG) as the core-forming segments biocompatible poly(ethylene glycol) (PEG) shell-forming blocks. The polymerization degree each was controlled by adjusting feeding ratio a furfuryl glycidyl ether ethylene oxide. size series found to be less than 10 nm in DMF. In water, polymers showed sizes larger...
The induced magnetic anisotropy of Co-Pt films on textured Ni-P-plated Al substrates depended the Pt content and texturing conditions. axis easy magnetization for Co film was along texture lines. surface grains an anisotropic Co-20at.%Pt those isotropic with same seemed to have almost shapes, no clear grain boundaries. No elongation or alignment normal grooves observed. remanent measured in circumferential radial directions affected strongly by content, a similar manner magnetostriction.<...
Nd12.6-xDyxFebal.CoyB6.2Zr0.1Ga0.3(x =0.3-1.9, y =5.8-18.3) alloys were processed by improved HDDR process with intermediate argon treatment and desorption under constant H2 pressure to increase remanence coercivity, respectively. In this study, we investigated effect of Co Dy contents on the magnetic properties powders. By process, powders containing 0.3 at.% 12 16 is increased a maximum 0.96 T, coercivity them 0.9 1.6 5.8 1570 kA/m. Undecomposed (Nd, Dy)2(Fe, Co)14B phase remains in...
A study evaluating the iron loss of a developed powder core under DC bias conditions with sinusoidal and square magnetizing voltage waveforms was conducted. It found that decreases when magnetic flux density increases. Also, variation in material caused by difference waveform is smaller than conventional steel core. Hence, suitable for applications such as inductors used power converters.