A5035438280- Analytical chemistry methods development
- Protein Interaction Studies and Fluorescence Analysis
- Nanoparticle-Based Drug Delivery
- Biosensors and Analytical Detection
- Identification and Quantification in Food
- Spectroscopy Techniques in Biomedical and Chemical Research
- Electrohydrodynamics and Fluid Dynamics
- Microtubule and mitosis dynamics
- Adenosine and Purinergic Signaling
- Calcium signaling and nucleotide metabolism
- Polyamine Metabolism and Applications
- Pluripotent Stem Cells Research
- Cell Adhesion Molecules Research
- Radiation Therapy and Dosimetry
- Cancer-related gene regulation
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Melamine detection and toxicity
- Blood properties and coagulation
- Advanced Cellulose Research Studies
- melanin and skin pigmentation
- Mast cells and histamine
- PARP inhibition in cancer therapy
- Protein purification and stability
- Genomics and Chromatin Dynamics
Kobe University
2020-2022
Nara Women's University
2014-2016
Gifu University
1983
Accurate, simple, and valuable analytical methods for detection of food contamination are rapidly expanding to evaluate the validity product quality because ethnic considerations safety. Herein molecularly imprinted nanogels (MIP-NGs), capable porcine serum albumin (PSA) recognition, were prepared as artificial molecular recognition elements. The MIP-NGs immobilized on a quartz crystal microbalance (QCM) sensor pork in real beef extract samples. MIP-NGs-based QCM showed high affinity...
Regulation of nanomaterial-cell interaction is an important requisite for a variety biomedical applications such as drug delivery systems and theranostics. Here, we demonstrate the regulation using oriented adsorption intrinsic immunoglobulin G (IgG) on molecularly imprinted polymer nanogels (MIP-NGs) capable recognizing fragment crystallizable (Fc) domain IgG. The unique recognition property resulted in suppression immune response Fc receptor-possessing macrophages natural killer cells due...
Nanomaterials have a great potential for use in various biorelated applications such as drug delivery systems and vivo imaging; understanding nanoparticle–cell interactions is an important requisite these applications. Herein, the interactions, including cellular uptake mechanism, were investigated detail using polymer nanogels possessing molecular recognition ability (molecularly imprinted nanogels: MIP-NGs) capable of protein corona regulation via albumin refractory cancer cell lines...
Nanomaterials have become increasingly promising for biomedical applications owing to their specific biological characteristics. As drug delivery vehicles, nanomaterials circulate in the bloodstream deliver encapsulated components target tissues. Protein corona regulation is one of approaches that gives stealth capability avoid immune response. The aim this study was develop molecularly imprinted polymer nanogels (MIP-NGs) capable protein regulation, using intrinsic human serum albumin (HSA)...
In mammals, the small Arf GTPase‐activating protein (SMAP) subfamily of proteins consists closely related members, SMAP1 and SMAP2. These factors reportedly exert distinct functions in membrane trafficking, as manifested by different phenotypes seen single knockout mice. The present study investigated whether SMAP interact genetically. We report for first time that simultaneous loss SMAP2 promotes apoptosis distal region E7.5 mouse embryos, likely resulting embryonic lethality. Thus, at...
Isolating cancer cells from tissues and providing an appropriate culture environment are important for a better understanding of behavior. Although various three-dimensional (3D) cell systems have been developed, techniques collecting high-purity spheroids without strong stimulation required. Herein, we report 3D system the isolation using enzymatically synthesized cellulose oligomers (COs) demonstrate that this isolates only under coculture conditions with normal cells. CO suspensions in...
Radiation therapy is a powerful approach for cancer treatment due to its low invasiveness. The development of radiation sensitizers great importance as they assist in providing at dose. In this study, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-modified gold nanocomposites different shapes were created using the grafting-to serve novel sensitizer with high cellular uptake. effect shape nanocomposite on uptake by breast cell line MCF-7 was also investigated. PMPC-modified nanostars...