A5027476864- Pleistocene-Era Hominins and Archaeology
- Forensic and Genetic Research
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Archaeology and ancient environmental studies
- Evolution and Genetic Dynamics
- Forensic Anthropology and Bioarchaeology Studies
- Race, Genetics, and Society
- Genetic and phenotypic traits in livestock
- Evolution and Paleontology Studies
- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Education, Psychology, and Social Research
- Isotope Analysis in Ecology
- Chronic Kidney Disease and Diabetes
- Plant and animal studies
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Marine animal studies overview
- demographic modeling and climate adaptation
- Indigenous Studies and Ecology
- Demographic Trends and Gender Preferences
- Chromosomal and Genetic Variations
University of Copenhagen
2022-2024
Lundbeck Foundation
2022-2023
Globe University
2021-2022
Max Planck Institute for Evolutionary Anthropology
2016-2021
Max Planck Society
2017
Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans. A striking observation support of this is an apparent monotonic decline ancestry observed humans Europe over the past 45,000 years. Here, we show artifact likely caused by gene flow between human populations, which not taken into account statistics previously used estimate ancestry. When apply a statistic avoids assumptions about demography taking advantage two high-coverage...
The value of dirty DNA Environmental can identify the presence species, even from distant past. Surveying three cave sites in western Europe and southern Siberia, Vernot et al. identified nuclear confirmed that it is close relatives anatomically modern humans—Neanderthal Denisovan individuals. A phylogenetic analysis modeling show sediment samples several layers corresponds to previously studied skeletal remains. These results demonstrate environmental data be applied study population...
We present a new R package admixr, which provides convenient interface for performing reproducible population genetic analyses (f3, D, f4, f4-ratio, qpWave and qpAdm), as implemented by command-line programs in the ADMIXTOOLS software suite. In traditional workflow, user must first generate set of text configuration files tailored to each individual analysis, often using combination shell scripting manual editing. The non-tabular output then need be parsed extract values interest prior...
Y chromosome evolution in Neanderthals The genomes of archaic hominins have been sequenced and compared with that modern humans. However, most individuals high-quality sequences available female. Petr et al. performed targeted sequencing the paternally inherited chromosomes from three two Denisovans (see Perspective by Schierup). Comparisons diverse human indicated that, similar to maternally mitochondria, Neanderthal were more closely related each other Denisovan chromosome. This result...
One of the goals population genetics is to understand how evolutionary forces shape patterns genetic variation over time. However, because populations evolve across both time and space, most processes also have an important spatial component, acting through phenomena such as isolation by distance, local mate choice, or uneven distribution resources. This dimension often neglected, partly due lack tools specifically designed for building evaluating complex spatio-temporal models. To address...
Ancient genome sequencing technologies now provide the opportunity to study natural selection in unprecedented detail. Rather than making inferences from indirect footprints left by present-day genomes, we can directly observe whether a given allele was present or absent particular region of world at almost any period human history within last 10,000 years. Methods for studying using ancient genomes often rely on partitioning individuals into discrete time periods regions world. However,...
Abstract Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans due deleterious alleles had accumulated the Neandertals after they split from human lineage. A striking observation support of this is an apparent monotonic decline ancestry observed Europe over past 45 thousand years. Here we show artifact caused by gene flow between West Eurasians and Africans, which not taken into account statistics previously used estimate...
Abstract One of the goals population genetics is to understand how evolutionary forces shape patterns genetic variation over time. However, because populations evolve across both time and space, most processes also have an important spatial component, acting through phenomena such as isolation by distance, local mate choice, or uneven distribution resources. This dimension often neglected, partly due lack tools specifically designed for building evaluating complex spatio-temporal models. To...
1 Abstract Geographic space is a fundamental dimension of evolutionary change, determining how individuals disperse and interact with each other. Consequently, has an important influence on the structure genealogies distribution genetic variants over time. Recently, development highly flexible simulation tools computational methods for genealogical inference greatly increased potential incorporating into models population variation. It now possible to explore spatial ecological parameters...
Abstract Ancient genome sequencing technologies now provide the opportunity to study natural selection in unprecedented detail. Rather than making inferences from indirect footprints left by present-day genomes, we can directly observe whether a given allele was present or absent particular region of world at almost any period human history within last 10,000 years. Methods for studying using ancient genomes often rely on partitioning individuals into discrete time periods regions world....
Beluga whales play a critical role in the subsistence economies and cultural heritage of Indigenous communities across Arctic, yet effects hunting on beluga remain unknown. Here, we integrate paleogenomics, genetic simulations, stable δ 13 C 15 N isotope analysis to investigate 700 y Mackenzie Delta area northwestern Canada. Genetic identification zooarchaeological remains, which is based radiocarbon dating, span three time periods (1290 1440 CE; 1450 1650 1800 1870 CE), indicates shifts sex...
Geographic space is a fundamental dimension of evolutionary change, determining how individuals disperse and interact with each other. Consequently, has an important influence on the structure genealogies distribution genetic variants over time. Recently, development highly flexible simulation tools computational methods for genealogical inference greatly increased potential incorporating into models population variation. It now possible to explore spatial ecological parameters can variation...
Abstract Ancient DNA has allowed the study of various aspects human history in unprecedented detail. However, because majority archaic specimens preserved well enough for genome sequencing have been female, comprehensive studies Y chromosomes Denisovans and Neandertals not yet possible. Here we present sequences first Denisovan ( Denisova 4 8 ), as three late Spy 94a , Mezmaiskaya 2 El Sidrón 1253 ). We find that split around 700 thousand years ago (kya) from a lineage shared by Neandertal...