A5085709707- Sinusitis and nasal conditions
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Nasal Surgery and Airway Studies
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Head and Neck Surgical Oncology
- Antimicrobial Peptides and Activities
- Otitis Media and Relapsing Polychondritis
- Whipple's Disease and Interleukins
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- interferon and immune responses
- Immune cells in cancer
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Nanocomposite Films for Food Packaging
- Protein Hydrolysis and Bioactive Peptides
- biodegradable polymer synthesis and properties
- NF-κB Signaling Pathways
- Eosinophilic Esophagitis
Northwestern University
2010-2022
University of Oklahoma
2018
University of Oklahoma Health Sciences Center
2017-2018
D.Y. Patil University
2017
ENT and Allergy
2015
Sutter Davis Hospital
2011
The Ohio State University
2007-2009
Lung Institute
2007-2009
Abstract Macrophages and their precursors, monocytes, are key cells involved in the innate immune response. Although both monocytes macrophages produce caspase-1, enzyme responsible for pro-IL-1β processing; limited ability to activate release functional IL-1β. In this context, because mutations pyrin gene (MEFV) cause inflammatory disorder familial Mediterranean fever, is believed regulate IL-1β processing. To determine whether variations expression explain difference between processing...
Abstract Background Chronic rhinosinusitis ( CRS ) is a disease characterized by inflammation of the nasal mucosa and paranasal sinuses. This may result in part from decreased epithelial barrier innate immune responses, leading to frequent bacterial fungal colonization. The objectives this study were investigate expression proteins palate lung epithelium clone PLUNC family patients with . Methods Nasal tissue samples collected control subjects without polyps. Expression members was analyzed...
Abstract Relative to monocytes, human macrophages are deficient in their ability process and release IL-1β. In an effort explain this difference, we used a model of IL-1β processing that is dependent upon bacterial escape into the cytosol. Fresh blood monocytes were compared with monocyte-derived (MDM) for response challenge Francisella novicida. Although both cell types produced similar levels mRNA intracellular pro-IL-1β, only readily released processed mature Baseline expression profiling...
We report that S100 proteins were reduced in patients with chronic rhinosinusitis (CRS). S100A8/9, which is important epithelial barrier function, was particularly decreased elderly CRS. Epithelial expression of S100A8/9 partly regulated by the IL-6 trans-signaling pathway. The goal this study to investigate whether or not age-related reduction CRS associated blunting trans-signaling. levels IL-6, soluble receptor (sIL-6R), gp130 (sgp130), and from control subjects (n = 10), without nasal...
Objectives/Hypothesis Chronic Rhinosinusitis ( CRS ) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest polyclonal autoantibody response. We previously found antibodies against BP180, component the hemidesmosome complex dominant epitope in autoimmune bullous pemphigoid, were at elevated levels polyp tissue. Given critical role hemidesmosomes maintaining epithelial integrity, we sought to investigate distribution...
IL-6 is a pleiotropic cytokine implicated in the pathogenesis of disorders such as sepsis and cancer. We noted that human monocytes are excellent producers compared with monocyte-derived macrophages. Because macrophages from molecule containing ankyrin repeats induced by LPS (MAIL) knockout animals have suppressed production, we hypothesized regulation MAIL key to production humans may explain differences between To test this hypothesis fresh were for expression response LPS. LPS-induced...
Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down-regulates immune functions. Translocation B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis. Group 3 innate lymphocytes (ILC3s) are important in barrier maintenance due to their expression cytokine IL-22, a critical regulator tissue responses repair during homeostasis inflammation. We found perturbed ILC3 function vitro vivo, revealing an unknown IL-23-mediated MAPK signaling...
IkappaBzeta is a novel member of the IkappaB family NFkappaB regulators, which modulates activity in nucleus, rather than controlling its nuclear translocation. specifically induced by IL-1beta and several TLR ligands positively regulates NFkappaB-mediated transcription genes such as IL-6 NGAL an binding co-factor. We recently reported that IL-1 cytokines, IL-18, strongly synergize with TNFalpha for IFNgamma production KG-1 cells, whereas same cytokines alone have minimal effects on...
Glucocorticoids (GCs) are commonly prescribed to patients with a variety of inflammatory disorders, including bowel disease (IBD). GCs mediate their immunomodulatory effects through many different mechanisms and target multiple signaling pathways. The GC dexamethasone downmodulates innate adaptive immune cell activation. IBD is the manifestation dysregulated response involving cells. Group 3 lymphocytes (ILC3s) have critical roles in mucosal inflammation. ILC3s secrete high levels cytokine...
The rationale of this elementary work was to develop starch based bio-coat for food items using permutation combination different sources (corn, potato, tapioca) and various plasticizers (glycerine, rice bran oil, sesame castrol soya bean oil olive oil). An eco-friendly alternative conventional petro-plastic polymer with a futuristic application as edible wraps intended the outcome. Amalgamation corn, tapioca potato in even proportions, generated finest bio-plastic sheet; glycerine chosen...
Abstract Macrophages and their precursors, monocytes, are key cells involved in the innate immune response. Although both monocytes macrophages produce caspase-1, enzyme responsible for processing of proIL-1β; limited ability to process release functional IL-1β. In this context, since mutations pyrin gene (MEFV) cause inflammatory disorder familial Mediterranean fever, protein is believed regulate To determine whether variations levels explain difference between monocyte IL-1β release, was...