A5091038978- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Racial and Ethnic Identity Research
- Complement system in diseases
- Innovations in Medical Education
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Cultural Competency in Health Care
- Muscle and Compartmental Disorders
- Healthcare cost, quality, practices
- Pancreatitis Pathology and Treatment
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- HIV-related health complications and treatments
- Adenosine and Purinergic Signaling
- Radiation Dose and Imaging
- Surgical Simulation and Training
- Innovative Teaching Methods
- Palliative Care and End-of-Life Issues
- Lanthanide and Transition Metal Complexes
- Immunotherapy and Immune Responses
- Simulation-Based Education in Healthcare
- COVID-19 and healthcare impacts
Icahn School of Medicine at Mount Sinai
2008-2022
Mount Sinai Hospital
2022
Dokter Bosman
2021
Mount Sinai Hospital
2020
ABSTRACT Importance Preliminary reports indicate that acute kidney injury (AKI) is common in coronavirus disease (COVID)-19 patients and associated with worse outcomes. AKI hospitalized COVID-19 the United States not well-described. Objective To provide information about frequency, outcomes recovery dialysis patients. Design Observational, retrospective study. Setting Admitted to hospital between February 27 April 15, 2020. Participants P atients aged ≥18 years laboratory confirmed Exposures...
Abstract Decay-accelerating factor (DAF) is a cell surface regulator that accelerates the dissociation of C3/C5 convertases and thereby prevents amplification complement activation on self cells. In context transplantation, DAF has been thought to primarily regulate antibody-mediated allograft injury, which in part serum complement-dependent. Based our previously delineated link between CD4 T responses, we evaluated effects donor Daf1 (the murine homolog human DAF) deficiency CD8...
While activation of serum complement mediates antibody-initiated vascular allograft injury, increasing evidence indicates that also functions as a modulator alloreactive T cells. We tested whether blockade at the C5 convertase step affects cell-mediated cardiac rejection in mice. The anti-C5 mAb BB5.1, which prevents formation C5a and C5b, synergized with subtherapeutic doses CTLA4Ig to significantly prolong survival C57BL/6 heart grafts were transplanted into naive BALB/c recipients....
Memory T-cells are mediators of transplant injury, and no therapy is known to prevent the development cross-reactive memory alloimmunity. Activated vitamin D immunomodulatory, deficiency, common in hemodialysis patients awaiting transplantation, associated with a heightened alloimmune response. Thus, we tested hypothesis that D3 supplementation would alloreactive T-cell formation D-deficient patients.We performed 12-month single-center pilot randomized, controlled trial 50,000 IU/week...
The purpose of this laboratory exercise is to model the changes in preload, afterload, and contractility on a simulated pressure-volume loop correlate those findings with common measurements clinical cardiovascular physiology. Once students have modeled these healthy heart, are asked look at case cardiogenic shock. Effects contractility, afterload explored, as well hemodynamic effects number student-suggested treatment strategies.
Most Americans indicate they are religious and/or spiritual and wish to have their beliefs taken into account when engaging with health care providers, yet gaps in medical education practice remain. To underscore the importance of spirituality as a significant social determinant health, team at Icahn School Medicine Mount Sinai New York developed mandatory training for students integrated all 4 years undergraduate curriculum.From 2014 2020, small group faculty took an innovative approach,...
Chan, Lili; Jaladanki, Suraj K.; Kaufman, Lewis; Sharma, Shuchita; Leisman, Staci A.; He, John C.; Murphy, Barbara T.; Coca, Steven G.; Nadkarni, Girish N. Author Information
Orozco Scott, Paloma C.; Catlett, Jerrel L.; Seah, Carina; Leisman, Staci A. Author Information