A5062448911- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Peripheral Nerve Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Vestibular and auditory disorders
- Genetic Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Epilepsy research and treatment
- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Migraine and Headache Studies
- Myofascial pain diagnosis and treatment
- Nerve Injury and Rehabilitation
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Neuroscience and Music Perception
- Shoulder Injury and Treatment
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
Affiliated Hospital of North Sichuan Medical College
2024-2025
Taipei Veterans General Hospital
2013-2022
National Yang Ming Chiao Tung University
2011-2020
The Neurological Institute
1998-2018
National Yang Ming University Hospital
2001-2014
Memorial Hospital
2013
Chang Gung University
2013
Chang Gung Memorial Hospital
2013
Cognitive Neuroimaging Lab
2011
Carrier (United States)
2011
Inherent fuzzy entropy is an objective measurement of electroencephalography (EEG) complexity, reflecting the robustness brain systems. In this study, we present a novel application multi-scale relative inherent using repetitive steady-state visual evoked potentials (SSVEPs) to investigate EEG complexity change between two migraine phases, i.e. inter-ictal (baseline) and pre-ictal (before attacks) phases. We used wearable headband device with O1, Oz, O2 Fpz electrodes collect signals from 80...
Abstract A genetic analysis identified 2 patients, approximately one‐tenth of our patients with familial parkinsonism, who had expanded trinucleotide repeats in SCA2 genes. The reduction 18 F‐dopa distribution both the putamen and caudate nuclei confirmed that nigrostriatal dopaminergic system was involved parkinsonian mutation.
Background Mutations in the PRRT2 gene have recently been identified patients with familial paroxysmal kinesigenic dyskinesia infantile convulsions (PKD/IC) and sporadic PKD/IC from several ethnic groups. To extend these recent genetic reports, we investigated frequency identities of mutations a cohort Taiwanese PKD/IC. Methodology Principal Findings We screened all 3 coding exons for 28 Among them, 13 had 15 were apparently cases. In total, 7 disparate patients, including 8 cases 5 The not...
The characteristics of the white matter network in schizophrenia patients with metabolic syndrome (MetS) remain unclear. This study analyzed MetS undergoing risperidone or clozapine treatment and explored their potential association index cognitive function. Diffusion tensor imaging was used to evaluate 19 comorbid (MetS-SZ) 20 without (nMetS-SZ), as well 25 healthy controls (HC). Differences these metrics were compared among through groups using ANCOVAs post-hoc testing. Associations...
Abstract Sympathetic skin response (SSR) and R–R interval variation (RRIV) were studied in 36 chronic, nondiabetic uremics to compare with their nerve conduction studies (NCS) clinical dysautonomia. Abnormal SSR was noted 5 (13.9%) patients, abnormal RRIV 14 (38.9%), NCS 26 (72.2%). The patients classified into three groups: group (GP) 1: “normal,” n = 21 (58.3%), normal SSR; GP 2: “isolated parasympathetic dysfunction,” 10 (27.8%), 3: “sympathetic sudomotor (13.9%), SSR. A significant...
Transcranial magnetic stimulation (TMS) of the motor cortex can interrupt voluntary contralateral rhythmic limb movements. Using method "resetting index" (RI), our study investigated TMS effect on different types bimanual Six normal subjects participated. For unimanual movement, each subject tapped either right or left index finger at a comfortable rate. fingers both hands in same (in-phase) direction opposite (antiphase) direction. was applied to hemisphere separately various intensities...
Abstract Among 242 patients with apparently sporadic Parkinson's disease, a 70‐year‐old man CAG repeat number of 37 in the SCA2 gene was identified. He has remained responsive to levodopa 14 years after onset and had no overt signs suggesting cerebellar dysfunction. Although it is not possible confirm if this patient de novo mutation gene, genetic defect seems be contributing his parkinsonian features further supports concept that sporadic, late‐onset, levodopa‐responsive disease may have...
This functional magnetic resonance imaging study verified an antagonistic pattern in which a concomitant deactivation of ipsilateral primary sensorimotor (SM1) was coupled to the contralateral SM1 activation healthy controls during unimanual hand grasping. Of note, dramatic reduction (loss pattern) observed movement intact hands by patients with unilateral brachial plexus injury. We propose that disappearance activities injury reflects interhemispheric inhibition, may mirror adaptive...
ABSTRACT Background The objective of this study was to clarify the excitability profiles somatosensory cortices in patients with paroxysmal kinesigenic dyskinesia. Methods Whole‐head magnetoencephalography used record evoked fields elicited by paired‐pulse electric stimulation median nerve 15 dyskinesia and a control group 18 age‐matched, healthy volunteers. Twelve were studied both drug‐off drug‐on state. Results inhibition ratios primary cortical P35m responses secondary significantly...
Theta burst stimulation is a type of pattern-specific repetitive transcranial magnetic that requires less time and lower intensity to induce long-lasting effects comparable those other protocols. This pilot study investigated whether continuous theta (cTBS) on the primary motor cortex reduced headache frequency in patients with migraine.Nine migraine were recruited into our study. All received 20 cTBS sessions (bursts 3 50-Hz TMS pulses at 200-ms intervals for 40 seconds), administered every...
Nonsuicidal self-injury (NSSI) is one of the major public health problems endangering adolescents. However, neural mechanisms NSSI still unclear. The purpose this study was to explore regional brain activity and corresponding circuits in drug-naïve adolescents with using amplitude low-frequency fluctuations (ALFF) combined functional connectivity (FC) analysis. Thirty-two (NSSI group) 29 healthy controls matched for sex, age, level education (HC were enrolled study. ALFF seed-based FC...
Background: Kennedy's disease (KD) is an X-linked recessive polyglutamine disease. Traditionally, it a lower motor neuron syndrome with additional features such as gynecomastia and tremor. Sensory symptoms are minimal if ever present. We used multimodal evoked potential (EPs) tests to study the distribution of involvement Methods: Visual, brainstem auditory, somatosensory EPs were studied in six KD patients. All them had typical presentations been proved genetically. Results: Abnormal...
<h3>Objective:</h3> To characterize movement-related neural oscillatory activity and to clarify its neurophysiologic role in paroxysmal kinesigenic dyskinesia (PKD). <h3>Methods:</h3> We recorded neuromagnetic event-related desynchronization (ERD) synchronization (ERS) activities response a self-paced finger-lifting task 16 patients with PKD 17 healthy controls. <h3>Results:</h3> The amplitude of α-ERD was comparable between the controls PKD, whereas either contralateral or ipsilateral β-ERS...