A5003969445- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cardiac Fibrosis and Remodeling
- Contact Dermatitis and Allergies
- Neuroinflammation and Neurodegeneration Mechanisms
- IL-33, ST2, and ILC Pathways
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- CAR-T cell therapy research
- Renin-Angiotensin System Studies
- Gut microbiota and health
- Immune responses and vaccinations
- Occupational exposure and asthma
- Cell Adhesion Molecules Research
- Erythrocyte Function and Pathophysiology
- Nuclear Receptors and Signaling
- Allergic Rhinitis and Sensitization
- Clostridium difficile and Clostridium perfringens research
- Inhalation and Respiratory Drug Delivery
- Signaling Pathways in Disease
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Ischemia and Reperfusion
- Drug-Induced Adverse Reactions
Federal Institute for Risk Assessment
2021-2025
Weizmann Institute of Science
2016-2020
Charité - Universitätsmedizin Berlin
2008-2017
German Rheumatism Research Centre
2014-2017
Freie Universität Berlin
2016
Hospital Santa Caterina
2014
Deutsches Herzzentrum der Charité
2008-2013
University Hospital Cologne
2013
University of Rostock
2013
Tissue Dynamics (Israel)
2013
Antibiotics disturbing microbiota are often used in treatment of poststroke infections. A bidirectional brain-gut axis was recently suggested as a modulator nervous system diseases. We hypothesized that gut may be an important player the course stroke.We investigated outcome focal cerebral ischemia C57BL/6J mice after 8-week decontamination with quintuple broad-spectrum antibiotic cocktail. These microbiota-depleted animals were subjected to 60 minutes middle artery occlusion or sham...
Background— This study is the first to examine effect of direct angiotensin II type 2 (AT ) receptor stimulation on postinfarct cardiac function with use novel nonpeptide AT agonist compound 21 (C21). Methods and Results— Myocardial infarction (MI) was induced in Wistar rats by permanent ligation left coronary artery. Treatment C21 (0.01, 0.03, 0.3 mg/kg per day IP) started 24 hours after MI continued until euthanasia (7 days MI). Infarct size assessed magnetic resonance imaging, hemodynamic...
Cytokines maintain intestinal health, but precise intercellular communication networks remain poorly understood. Macrophages are immune sentinels of the tissue and critical for gut homeostasis. Here, we show that in a murine inflammatory bowel disease (IBD) model based on macrophage-restricted interleukin-10 (IL-10) receptor deficiency (
Abstract Emerging evidence suggests a cardioprotective role of the angiotensin AT2R, albeit underlying cellular mechanisms are not well understood. We aimed in this article to elucidate potential cardiac AT2R regulating immune response ischemic heart injury. Seven days after myocardial infarction rats, double-immunofluorescence staining showed that was detected fraction CD8+ T cells infiltrating peri-infarct myocardium. developed method allowed isolation CD8+AT2R+ using modified MACS, and...
TH17 cells are major drivers of inflammation and involved in several autoimmune diseases. Tissue is a beneficial host response to infection, but it can also contribute autoimmunity. The crosstalk between tissue the immune system during an inflammatory key for preserving integrity restoring physiological processes. However, how inflamed regulates magnitude by controlling pro-inflammatory T not well characterized so far. Here we show that accumulating small intestine upon express IL-33...
The severity of global pandemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has engaged the researchers and clinicians find key features triggering viral infection lung cells. By utilizing such crucial information, scientists try combat spread virus. Here, in this work, we performed silico analysis protein-protein interactions between receptor-binding domain (RBD) spike protein human angiotensin-converting enzyme 2 (hACE2) receptor highlight alteration that happened...
Abstract The expression pattern of angiotensin AT2 receptors with predominance during fetal life and upregulation under pathological conditions tissue injury/repair process suggests that may exert an important action in adaptive mechanisms. Less is known about acute ischemia-induced cardiac injury. We aimed here to elucidate the role after myocardial infarction. Double immunofluorescence staining showed were mainly detected clusters small c-kit+ cells accumulating peri-infarct zone...
Abstract Myocardial infarction ( MI ) is a major condition causing heart failure HF ). After , the renin angiotensin system RAS and its signalling octapeptide II (Ang II) interferes with cardiac injury/repair via AT 1 2 receptors 1R, 2R). Our study aimed at deciphering mechanisms underlying link between cellular components of immune response relying on rodent model as well patients. Flow cytometric analyses showed an increase in expression CD 4 + 2R cells rat spleen post‐infarction, but...
Monocytes are circulating short-lived macrophage precursors that recruited on demand from the blood to sites of inflammation and challenge. In steady state, classical monocytes give rise vasculature-resident cells patrol luminal side endothelium. addition, feed compartments selected organs, including barrier tissues, such as skin intestine, well heart. Monocyte differentiation under conditions has been studied in considerable detail. contrast, monocyte non-inflammatory remains less...
Our aims were to assess the spatiotemporal development of brain pathology in a mouse model chronic hypoperfusion using magnetic resonance imaging (MRI), and test whether renin-angiotensin system (RAS) can offer therapeutic benefit. For first time, different patterns cerebral blood flow alterations observed hypoperfused mice that ranged from an immediate dramatic delayed decrease perfusion. Diffusion tensor revealed increases several quantitative parameters regions are indicative white-matter...
Protective immune responses depend on the formation of synapses between T cells and antigen-presenting (APCs). The two main LFA-1 ligands, ICAM-1 ICAM-2, are co-expressed many cell types, including APCs blood vessels. Although these molecules were suggested to be key players in studied vitro, their contribution helper priming vivo is unclear. Here, we used transgenic mice intravital imaging examine role dendritic (DC) ICAM-2 naive CD4 differentiation skin-draining lymph nodes. Surprisingly,...
Results regarding protective effects of dipeptidyl peptidase 4 (DPP4) inhibitors in renal ischaemia-reperfusion injury (IRI) are conflicting. Here we have compared structurally unrelated DPP4 a model IRI.IRI was induced uninephrectomized male rats by artery clamping for 30 min. The sham group but not subjected to IRI. or vehicle were given p.o. once daily on three consecutive days prior IRI: linagliptin (1.5 mg·kg-1 ·day-1 ), vildagliptin (8 ) and sitagliptin (30 ). An additional received...
Abstract Background Apart from Ni 2+ , Co and Pd ions commonly trigger T cell‐mediated allergic contact dermatitis. However, in vitro frequencies of metal‐specific cells the mechanisms antigen recognition remain unclear. Methods Here, we utilized a CD154 upregulation assay to quantify ‐, ‐specific CD4+ peripheral blood mononuclear (PBMC). Involved αβ cell receptor (TCR) repertoires were analyzed by high‐throughput sequencing. Results Peripheral incubation with NiSO 4 CoCl 2 PdCl increased +...
Dendritic cells (DC) are unrivaled in their potential to prime naive T by presenting antigen and providing costimulation. DC furthermore believed decode context virtue of pattern recognition receptors polarize through cytokine secretion towards distinct effector functions. Diverse polarized helper (TH) have been explored great detail. In contrast, studies instructing date largely restricted vitro settings or adoptively transferred DC. Here we report efforts unravel the response cognate cell...
Allergic contact dermatitis is a widespread T cell-mediated inflammatory skin disease, but
Abstract The small intestine hosts specialized lymphoid structures, the Peyer's patches, that face gut lumen and are overlaid with unique epithelial cells, called microfold (M) cells. M cells considered to constitute an important route for antigen uptake in mucosal immune system. Here, we used intravital microscopy define cell populations, which close contact potentially sample antigen. We present live evidence DCs enter pockets highlight abundance of mononuclear phagocytes these structures....