A5023561526- Bone and Dental Protein Studies
- dental development and anomalies
- Bone Metabolism and Diseases
- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Axon Guidance and Neuronal Signaling
- Developmental Biology and Gene Regulation
- Connexins and lens biology
- Tendon Structure and Treatment
- Connective tissue disorders research
- S100 Proteins and Annexins
- Laser Applications in Dentistry and Medicine
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
- Skin and Cellular Biology Research
- Cancer-related gene regulation
Chonnam National University
2008-2025
Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on management, tissue repair remains limited. Metformin, first-line medication for diabetes treatment, has positive effects bone health in nondiabetic patients. However, its potential repairing unclear. Therefore, this study aimed to evaluate the reparative of metformin periodontitis-damaged mice. A mouse model was used, which silk ligatures were removed from molars after inducing...
Abstract Background The association between diabetes mellitus (DM) and bone diseases is acknowledged. However, the mechanistic pathways leading to alveolar (AB) destruction remain unclear. This study aims elucidate mechanical forces (MF)‐induced AB in DM its underlying mechanism. Methods In vivo periodontal tissue responses MF were evaluated rats with diabetes. vitro human ligament (PDL) cells either treated advanced glycation end products (AGEs) alone or AGEs MF. Results vivo, transcription...
Abstract Aim To study the role of sclerostin in periodontal ligament (PDL) as a homeostatic regulator biophysical‐force‐induced tooth movement (BFTM). Materials and Methods BFTM was performed rats, followed by microarray, immunofluorescence, situ hybridization, real‐time polymerase chain reaction for detection identification molecules. The space analysed via micro‐computed tomography. Effects on osteoclastogenesis bone resorption were evaluated bone‐marrow‐derived cells mice. In vitro human...
Abstract Human mesenchymal stem cells (hMSCs), characterized by rapid in vitro expandability and multi‐differentiation potential, have been widely used the clinical field of tissue engineering. Recent studies shown that various signaling networks are involved growth differentiation hMSCs. Although Wnts their downstream components implicated regulation hMSCs, role Wnt hMSC self‐renewal is still controversial. Here, it was observed activation endogenous canonical with LiCl, which decreased...
Differentiated ameloblasts secret enamel matrix proteins such as amelogenin, ameloblastin, and enamelin. Expression levels of these are regulated by various factors. To find a new regulatory factor for ameloblast differentiation, we performed 2D-PAGE analysis using mouse lineage cell line (mALCs) cultured with mineralizing medium. Of identified proteins, family sequence similarity 50 member A (Fam50a) was significantly increased during differentiation mALCs. Fam50a protein also highly...
We aimed to identify a key molecule that maintains periodontal tissue homeostasis during biophysical force-induced tooth movement (BTM) by orchestrating alveolar bone (AB) remodelling.Differential display-PCR was performed molecules for BTM in rats. To investigate the localization and expression of identified molecules, immunofluorescence, real-time RT-PCR Western blotting were rats human ligament (PDL) cells. Functional test micro-CT analysis examine vivo effects on BTM.Secretory leucocyte...
Tooth development occurs through a complex and intricate set of gene‐expression cascades. Although its early events have been examined extensively, there are fewer reports on the late events, such as dental hard‐tissue formation. This study searched for genes involved in stages tooth development. Differential display–polymerase chain reaction revealed myelin basic protein (MBP) mRNA to be expressed differentially second molar root stage germs compared with third cap/early bell germs. The MBP...
The dental pulp is a highly innervated tissue transmitting pain-related sensations in the tooth. Consequently, understanding intricacies of its innervation mechanism odontogenesis crucial for gaining insights into pain and developing pain-modulating agents. This study examined neuroregulatory molecules such as neurotrophic factors (nerve growth factor [NGF], brain-derived [BDNF], neurotrophin-4 [NTF-4], neurturin [NRTN]) neuroinhibitory (slit2, ephrin isoforms netrin-1) rat teeth with...