A5102749643- Retinoids in leukemia and cellular processes
- Bone Metabolism and Diseases
- Natural product bioactivities and synthesis
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Bone and Dental Protein Studies
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Sesquiterpenes and Asteraceae Studies
- Inflammasome and immune disorders
- Cancer Research and Treatments
- Advanced X-ray and CT Imaging
- Lipid Membrane Structure and Behavior
- Genetic and Kidney Cyst Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neonatal Respiratory Health Research
- T-cell and Retrovirus Studies
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Legionella and Acanthamoeba research
- NF-κB Signaling Pathways
Chonnam National University
2003-2025
Korea University
2007-2024
Korea Basic Science Institute
2023
Korea Institute of Science and Technology
2023
Korean Association Of Science and Technology Studies
2023
Friedrich Miescher Institute
2023
Okinawa Institute of Science and Technology Graduate University
2023
The University of Texas Southwestern Medical Center
2023
Southwestern Medical Center
2023
Gwangju Institute of Science and Technology
2023
Abstract Supplementation of mesenchymal stem cells (MSCs) at sites bone resorption is required for homeostasis because the non-proliferation and short lifespan properties osteoblasts. Calcium ions (Ca 2+ ) are released from surfaces during osteoclast-mediated resorption. However, how elevated extracellular Ca concentrations would alter MSCs behavior in proximal largely unknown. In this study, we investigated effect on phenotype depending concentrations. We found that promoted cell...
The cause of chronic inflammatory periodontitis, which leads to the destruction periodontal ligament and alveolar bone, is multifactorial. An increasing number studies have shown clinical significance NLRP3-mediated low-grade inflammation in degenerative disorders, but its causal linkage age-related periodontitis has not yet been elucidated. In this study, we investigated involvement NLRP3 inflammasome therapeutic potential inhibition bone loss by using vivo vitro models. poor quality bones...
Abstract Defects in plasma membrane repair can lead to muscle and heart diseases humans. Tripartite motif-containing protein (TRIM)72 (mitsugumin 53; MG53) has been determined rapidly nucleate vesicles at the site of damage, but underlying molecular mechanisms remain poorly understood. Here we present structure Mus musculus TRIM72, a complete model TRIM E3 ubiquitin ligase. We demonstrated that interaction between TRIM72 phosphatidylserine-enriched membranes is necessary for its oligomeric...
<title>Abstract</title> Osteoclasts are essential for bone remodeling; however, their hyperactivity leads to pathological loss. While inflammasome-activated caspases known influence osteoclastogenesis, the role of caspase-11, beyond its conventional function in pyroptosis, remains unclear. Here, we identified caspase-11 as a pivotal regulator RANKL-induced osteoclast differentiation. Caspase-11 expression and activity were elevated tissues exhibiting excessive resorption RANKL-stimulated...
Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on management, tissue repair remains limited. Metformin, first-line medication for diabetes treatment, has positive effects bone health in nondiabetic patients. However, its potential repairing unclear. Therefore, this study aimed to evaluate the reparative of metformin periodontitis-damaged mice. A mouse model was used, which silk ligatures were removed from molars after inducing...
Hosts utilize macroautophagy/autophagy to clear invading bacteria; however, bacteria have also developed a specific mechanism survive by manipulating the host cell autophagy mechanism. One pathogen, Legionella pneumophila, can hinder using effector protein RavZ that cleaves phosphatidylethanolamine-conjugated LC3 on phagophore membrane. However, detailed molecular mechanisms associated with function of hitherto remained unclear. Here, we report biochemical characteristics RavZ-LC3...
The peroxisome proliferator-activated receptor (PPAR)-α agonist fenofibrate is used as a lipid-lowering agent to reduce cholesterol and triglyceride in blood. In this study, we investigated whether affects osteoblast differentiation of osteogenic precursor cells. Quantitative real-time PCR alkaline phosphatase (ALP) staining assays revealed that can enhance the C3H10T1/2 MC3T3-E1 contrast with fenofibrate, PPARγ rosiglitazone decreased or did not affect expression genes these Fenofibrate...
Abstract The acquired drug resistance as well extramedullary tissue infiltration of leukemic cells is a major obstacle in leukemia treatment. Excessive egress cell blasts results invasion into various organs or tissues, which facilitated by the catalytic activities matrix metalloproteinases (MMPs). However, migration chemoresistant remains unclear. Here, we generated drug‐resistant variants human acute myeloid line (AML‐2/WT) stepwise exposure to anticancer drugs and evaluated level MMP‐2...
Osteoporosis is a major public health concern, which requires novel therapeutic strategies to prevent or mitigate bone loss.Natural compounds have attracted attention as potential agents due their safety and efficacy.In this study, we investigated the regulatory activities of boeravinone B (BOB), natural rotenoid isolated from medicinal plant Boerhavia diffusa, on differentiation osteoclasts mesenchymal stem cells (MSCs), two main cell components responsible for remodeling.We found that BOB...
Aminoacyl tRNA synthetase-interacting multifunctional protein 1 (AIMP1) has been reported to have antitumor effects in various tumor models. However, mechanisms by which AIMP1 ameliorates tumorigenesis are not well understood. As NK cells a major cell type involved activities and is known activate professional APCs, we determined whether induced activation directly or via these APCs. the expression of surface markers on murine total splenocytes, although did induce cells. The inductive...
The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues regulate cellular functions, including cell migration. migration of mesenchymal stem cells (MSCs) bone remodeling sites is important for homeostasis. Recently, we have suggested that osteopontin (OPN) significant chemoattractant in MSC sites. objective this study was determine whether the unit OPN control We found loss induced by silencing IFT88 reduced OPN-induced MSCs. effect...
Granulocyte macrophage-colony stimulating factor (GM-CSF) has immuno-stimulatory effects.We hypothesized that GM-CSF plays an important role both in lipopolysaccharide (LPS)-and hemorrhage-induced acute lung injury (ALI).We also postulated augments LPS-induced inflammation by priming neutrophils.ALI was induced GM-CSF-/-or control C57BL mice either LPS injection or hemorrhage.Lung (by expression for tumor necrosis factor-(TNF-), macrophage inflammatory protein-2 (MIP-2), interleukin-1 (IL-1...
The CUE domain-containing 2 (CUEDC2) protein plays critical roles in many biological processes, such as the cell cycle, inflammation, and tumorigenesis. However, whether CUEDC2 is involved osteoblast differentiation a role bone regeneration remains unknown. This study investigated of osteogenesis its underlying molecular mechanisms. We found that expressed tissues. expression decreased during development BMP2-induced differentiation. overexpression suppressed osteogenic precursor cells,...
Abstract Objective Various surface modification techniques that can further improve the function and usability of stainless steel as a medical device have been reported. In present study, physical biological properties nanoporous well its usefulness for drug delivery were assessed. Methods The specimen was prepared with circular disk shape (15 mm in diameter 1 thickness). subjected to electropolishing at constant voltage 20 V 10 A min an acidic environment (50% H 2 SO 4 ). Everolimus (EVL)...
Current treatment for leukemia largely depends on chemotherapy. Despite the progress in efficacy of chemotherapy, a poor outcome consequent upon chemoresistance against conventional anti-cancer drugs still remains to be solved. In this study, we report 5-diphenylacetamido-indirubin-3'-oxime (LDD398) as novel mitochondria-targeting anti-leukemic agent, which is derivative indirubin used traditional medicine. Treatment with LDD398 resulted caspase activation, cell death, and growth arrest at...
Many sesquiterpene lactone compounds either induce or enhance the cell differentiation of human leukemia cells. However, we reported in a previous study that santonin, eudesmanolide lactone, exerts no effects on In this report, to evaluate possibility chemically modifying santonin into its derivatives with inducing activity, synthesized series derivatives, and determined their cellular promyelocytic HL-60 system. A diacetoxy acetal derivative (DAAS) was found significant dose-dependent...