A5047023660- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- Signaling Pathways in Disease
- Renal and related cancers
- Cell Adhesion Molecules Research
- Genetic and Kidney Cyst Diseases
- Bone and Joint Diseases
- NF-κB Signaling Pathways
- Oral microbiology and periodontitis research
- Heme Oxygenase-1 and Carbon Monoxide
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Endodontics and Root Canal Treatments
- S100 Proteins and Annexins
- Inflammasome and immune disorders
Chonnam National University
2017-2020
The cause of chronic inflammatory periodontitis, which leads to the destruction periodontal ligament and alveolar bone, is multifactorial. An increasing number studies have shown clinical significance NLRP3-mediated low-grade inflammation in degenerative disorders, but its causal linkage age-related periodontitis has not yet been elucidated. In this study, we investigated involvement NLRP3 inflammasome therapeutic potential inhibition bone loss by using vivo vitro models. poor quality bones...
The peroxisome proliferator-activated receptor (PPAR)-α agonist fenofibrate is used as a lipid-lowering agent to reduce cholesterol and triglyceride in blood. In this study, we investigated whether affects osteoblast differentiation of osteogenic precursor cells. Quantitative real-time PCR alkaline phosphatase (ALP) staining assays revealed that can enhance the C3H10T1/2 MC3T3-E1 contrast with fenofibrate, PPARγ rosiglitazone decreased or did not affect expression genes these Fenofibrate...
Abstract Plant homeodomain finger protein 20 (PHF20), a methyl lysine effector protein, is component MOF-NSL acetyltranferase complex. Global deletion of PHF20 has shown spinal bone defects and reduced skeletal formation. However, the molecular basis involved in development not been elucidated yet. The objective this study was to determine role osteoblast differentiation mineralization. Expression gradually increased during differentiation. Overexpression enhanced ALP activity mineralized...
The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues regulate cellular functions, including cell migration. migration of mesenchymal stem cells (MSCs) bone remodeling sites is important for homeostasis. Recently, we have suggested that osteopontin (OPN) significant chemoattractant in MSC sites. objective this study was determine whether the unit OPN control We found loss induced by silencing IFT88 reduced OPN-induced MSCs. effect...
The CUE domain-containing 2 (CUEDC2) protein plays critical roles in many biological processes, such as the cell cycle, inflammation, and tumorigenesis. However, whether CUEDC2 is involved osteoblast differentiation a role bone regeneration remains unknown. This study investigated of osteogenesis its underlying molecular mechanisms. We found that expressed tissues. expression decreased during development BMP2-induced differentiation. overexpression suppressed osteogenic precursor cells,...
Abstract Aim To explore the involvement of TLR5 in pulp inflammation and to examine effects activation with its ligand, FlaB protein, on pro‐inflammatory gene expression. Methodology expression dental tissues human cells (hDPCs) were determined by immunohistochemistry, immunocytochemistry, Western blots RT‐PCR analyses. role TLR5, hDPCs treated recombinant protein (500 ng mL −1 ) activate receptor or a small interfering RNA against (si‐TLR5) downregulate receptor. After exposure FlaB,...