A5027455810- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanofluid Flow and Heat Transfer
- Microplastics and Plastic Pollution
- Polymer Surface Interaction Studies
- Alzheimer's disease research and treatments
- Laser-Ablation Synthesis of Nanoparticles
- Effects and risks of endocrine disrupting chemicals
- Barrier Structure and Function Studies
- Membrane Separation and Gas Transport
- Field-Flow Fractionation Techniques
- Extracellular vesicles in disease
- Graphene research and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Metal-Organic Frameworks: Synthesis and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
University of Illinois Urbana-Champaign
2023-2024
Pennsylvania State University
2021
Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials applications in mitigating IRI-induced cell tissue damage through modulating inflammatory responses, enhancing angiogenesis, promoting repair. Despite these advances, a more systematic understanding of exosomes from different sources their biotransport is critical for optimizing therapeutic efficacy accelerating clinical...
Nanoparticles have emerged as potential transporters of drugs targeting Alzheimer's disease (AD), but their design should consider the blood-brain barrier (BBB) integrity and neuroinflammation AD brain. This study presents that aging is a significant factor for brain localization retention nanoparticles, which we engineered to bind with reactive astrocytes activated microglia. We assembled 200 nm-diameter particles using block copolymer poly(lactic-co-glycolic acid) (PLGA) CD44-binding...
Nanoparticles tethered with vasculature-binding epitopes have been used to deliver the drug into injured or diseased tissues via bloodstream. However, extent that blood flow dynamics affects nanoparticle retention at target site after adhesion needs be better understood. This knowledge gap potentially underlies significantly different therapeutic efficacies between animal models and humans. An experimentally validated mathematical model accurately simulates effects of on retention, thus...
Abstract Delivery of drug using nanocarriers tethered with vasculature-targeting epitopes aims to maximize the therapeutic efficacy while minimizing side effects. Circadian rhythm which is governed by central nervous system has implications for targeted delivery due sleep-wake cycle changes in blood flow dynamics. This paper presents an advanced fluid dynamics modeling method that based on viscous incompressible shear-rate (blood) coupled advection-diffusion equation simulate formation...
Finned hierarchical MOF particles (Cu(BDC) nanosheets as fins grown perpendicularly on Ni2(BDC)2(DABCO) hexagonal prisms) were synthesized modified cellulose support. The exposed the open Cu(II) sites Cu(BDC) to enable selective 1-hexene/n-hexane separation.