A5070555363- Veterinary Equine Medical Research
- Osteoarthritis Treatment and Mechanisms
- Veterinary Orthopedics and Neurology
- Veterinary Medicine and Surgery
- Musculoskeletal synovial abnormalities and treatments
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- Diabetes and associated disorders
- Exercise and Physiological Responses
- Bone Tissue Engineering Materials
- Tendon Structure and Treatment
- Dental Implant Techniques and Outcomes
- Viral Infections and Vectors
- Virus-based gene therapy research
- Animal Nutrition and Physiology
- Veterinary Pharmacology and Anesthesia
- Reproductive Physiology in Livestock
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Rabbits: Nutrition, Reproduction, Health
- Advanced Glycation End Products research
- Viral gastroenteritis research and epidemiology
- Endodontics and Root Canal Treatments
- Veterinary Oncology Research
- Growth Hormone and Insulin-like Growth Factors
Swedish University of Agricultural Sciences
2015-2025
Swedish Veterinary Agency
2022-2023
Abstract ‘Staggering disease’ is a neurological disease entity considered threat to European domestic cats ( Felis catus ) for almost five decades. However, its aetiology has remained obscure. Rustrela virus (RusV), relative of rubella virus, recently been shown be associated with encephalitis in broad range mammalian hosts. Here, we report the detection RusV RNA and antigen by metagenomic sequencing, RT-qPCR, in-situ hybridization immunohistochemistry brain tissues 27 out 29 non-suppurative...
Congenital tremor is associated with demyelination of the brain and spinal cord clinically noted as outbreaks trembling shaking in newborn piglets during a limited time-period. Six forms disease have been described, where form AII may be caused by an, yet, unidentified viral infection. This study aimed to investigate presence astrovirus circovirus sequencing polymerase chain reaction (PCR) analysis relating findings occurrence lesions brain, 4-6 days-old obtained from clinical outbreak...
Abstract Background Osteoarthritis (OA) is a common, age-related joint disease in cats. The common finding of bilateral symmetric involvement may suggest influence from systemic factors, and could imply that body parameters such as excess fat cat size are important for OA development. We aimed to investigate associations between composition whole-body scores 72 cats, using computed tomography (CT), if serum concentrations the metabolic mediators leptin, adiponectin insulin-like growth...
Summary The carpal joints are common sites of traumatic arthritis and osteoarthritis (OA) in athletic horses. pro‐inflammatory cytokines interleukin (IL)‐6 tumour necrosis factor (TNF) may be great importance the development intra‐articular lesions. aim present study was to investigate possible associations between synovial fluid levels bioactive IL‐6 TNF different types joint lesions seen OA. Synovial collected from horses with lameness immediately before arthroscopic surgery. Articular...
Echinococcus multilocularis is a zoonotic tapeworm with sylvatic lifecycle and an expanding range in Europe. Monitoring efforts following its first identification 2011 Sweden have focused on the parasite's definitive host, red fox (Vulpes vulpes). However, identifying rodent intermediate hosts important to recognize opportunities for parasite transmission. During 2013-2015, livers from total of 1566 rodents four regions were examined E. metacestode lesions. Species identity suspect lesions...
The effects of high mobility group box protein (HMGB)-1, interleukin (IL)-1β, and IL-6 on equine articular chondrocytes were investigated, with emphasis detecting differences between anatomical sites exposed to different loading in vivo, using three-dimensional (3D) cell cultures established from dorsal radial facet (DRF, highly loaded) palmar condyle (PC, less the third carpal bone (C3). Expression important genes involved cartilage metabolism, presence glycosaminoglycans oligomeric matrix...
Abstract Background Obesity is associated with insulin resistance (IR) and considered a risk factor for diabetes mellitus (DM) in cats. It has been proposed that homeostasis model assessment (HOMA-IR), which the product of fasting serum (mU/L) glucose (mmol/L) divided by 22.5, can be used to indicate IR. The objectives this study were threefold: (i) evaluate associations between body fat, insulin, HOMA-IR, (ii) determine population-based reference interval HOMA-IR healthy lean cats, (iii)...
Abstract Formation of synovial joints includes phenotypic changes the chondrocytes and organisation their extracellular matrix is regulated by different factors signalling pathways. Increased knowledge normal processes involved in joint development may be used to identify similar regulatory mechanisms during pathological conditions joint. Samples distal radius were collected from prenatal postnatal equine growth plates, zones Ranvier articular cartilage with aim identifying Notch components...
Abstract Objective —To determine the effects of interleukin (IL)-6 and IL-1β stimulation on expression growth differentiation factor (GDF)-5 Wnt signaling pathway genes in equine chondrocytes. Sample —Macroscopically normal articular cartilage samples from 6 horses osteochondral fragments (OCFs) 3 horses. Procedures —Chondrocyte pellets were prepared cultured without or following with IL-6 for 1, 2, 12, 48 hours; GDF-5 was determined a quantitative real-time PCR assay. Expression various...
Osteoarthritis is a pain-associated progressive disease and pain mediators, such as opioid receptors, expressed in articular cartilage could represent novel therapeutic targets. Acute chronic stages of OA indicate different metabolic abilities the chondrocytes depending on inflammatory state. This study aimed to investigate response healthy osteoarthritic their expression release mediators acute inflammation. Interleukin-1 beta (IL-1β) lipopolysaccharide (LPS) were used induce an cultured...
Abstract Long bone fractures are common and sometimes difficult to treat. Autologous (AB), bovine calcium phosphates used stimulate growth with varying results. In the present study, a phosphate cement (CPC) that previously showed promising grafting capabilities was evaluated for first time in long defect. A radius defect of 20 mm created rabbits. The filled by either hollow CPC implant had been manufactured as replica rabbit through indirect 3D printing, or particulate AB control. Defect...
Feline diabetes mellitus is a common endocrine disease with increasing prevalence. It shows similarities human type 2 and characterized by insulin resistance deficient secretion. Moreover, cats humans belong to the very few species that form amyloid depositions in pancreatic islets. However, little known about cat islet function no studies have addressed secretion from isolated islets ex vivo. The aim of this study was establish protocol for isolation Langerhans pancreata euthanized due...
The development and early morphological features of feline hip osteoarthritis (OA) are largely unknown. Tears in the acetabular labrum at chondrolabral transition zone suggested to be important pathogenesis human OA, but cats such lesions have not been described. We investigated associations between computed tomography (CT)-detected joint changes microscopic articular cartilage lesions, distribution detected changes, histologically evaluated margin (AM) joints from 20 cats. Histologic...
Elbow osteoarthritis (OA) is common in cats and radiography typically used for diagnosis. However computed tomography (CT), with its multiplanar three-dimensional characteristics, could have significant advantages assessment of OA compared to radiography, particularly early the disease process. The study objectives were compare CT histologic changes, investigate stage that detect, search specific changes images strongly predictive feline elbow OA. Right elbows from 29 evaluated by CT,...
In animal studies on bone healing, the effect of housing space and physical activity are seldom taken into account. Bone formation was evaluated in New Zealand White rabbits (mean ± SEM BW: 3.9 0.11 kg) with a critical defect after 12 weeks rehabilitation pair-housing 3 m2 large floor pens (Floor, n = 10) or standard single 0.43 cages (Cage, 10). randomised full-factorial study, replica calcium phosphate cement (CPC, autologous (AB, implanted unilateral 20 mm radius defect. Post-mortem,...
Hypophysitis has been reported occasionally in dogs, with most cases resembling primary lymphocytic hypophysitis man. Although it is generally assumed that lymphocytes are not present normally the canine pituitary gland, few studies have investigated this hypothesis. However, recognized gland of people and horses without signs disease. It unknown to what degree lymphocyte infiltration might occur as an incidental finding dogs. The aim study was investigate presence distribution dogs clinical...
Determination of the nutritional condition, including estimation amounts total body fat (tBF), at routine postmortem examination cats is typically based on subjective visual assessment. Subjective assessment may result in uncertainties regarding degree overweight, and objective methods that provide a numerical value reflecting tBF could be valuable to accurately judge excess fat. We investigated if falciform pad weight (FFPW) was correlated used detect overweight obesity cats. The FFPW femur...
Development of whole-body multidetector computed tomography (MDCT) methods have the potential to allow investigations into relations between feline osteoarthritis (OA) and obesity. In one MDCT examination all joints in an animal total body fat content can be evaluated. However, studies investigating correlation presence joint lesions detected by macroscopic evidence OA are lacking.