A5103032451- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Sperm and Testicular Function
- Renal and related cancers
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Ectopic Pregnancy Diagnosis and Management
University of Missouri Health System
2023-2025
University of Missouri
2023-2025
National Institute of Environmental Health Sciences
2024-2025
National Institutes of Health
2024-2025
Washington State University
2020-2022
Journal Article Accepted manuscript Loss of progesterone receptor in smooth muscle cells has no impact on oviductal contraction and preimplantation embryo development Get access Emily A McGlade, McGlade Department OB/GYN & Women's Health, School Medicine, University Missouri, Columbia, 65211, USAReproductive Developmental Biology Laboratory, National Institute Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA Search for other works by this author on: Oxford...
More than 60% of pregnancy losses occur during the first trimester, highlighting need to understand role oviduct in early pregnancy. In this study, we conditionally ablated classical progesterone receptor ( Pgr ) oviductal epithelial cells, called d/d mouse model. We found that 40% embryos collected from females were nonviable or developmentally delayed, indicating PGR expression is crucial for embryonic development. Single-cell RNA sequencing revealed up-regulation proinflammatory genes,...
One of the endogenous estrogens, 17β-estradiol (E2) is a female steroid hormone secreted from ovary. It well established that E2 causes biochemical and histological changes in uterus. However, it not completely understood how regulates oviductal environment vivo. In this study, we assessed effect on each cell type, using an ovariectomized-hormone-replacement mouse model, single-cell RNA-sequencing (scRNA-seq), situ hybridization, cell-type-specific deletion mice. We found type oviduct...
Abstract Ciliary action performs a critical role in the oviduct (Fallopian tube) during pregnancy establishment through sperm and egg transport. The disruption of normal ciliary function affects oocyte pick-up is contributing factor to female infertility. Estrogen an important regulator promotes ciliogenesis several species. Global loss estrogen receptor α (ESR1) leads We have previously shown that ESR1 oviductal epithelial cell layer required for fertility. Here, we assessed on...
Abstract The epithelial cell lining of the oviduct plays an important role in oocyte pickup, sperm migration, preimplantation embryo development, and transport. layer comprises ciliated nonciliated secretory cells. ciliary function has been shown to support gamete movement oviduct, yet not well characterized. Therefore, our goal was generate a cell-specific Cre recombinase mouse model study oviductal A knock-in model, Ovgp1Cre:eGFP, created by expressing from endogenous Ovgp1 (oviductal...
Abstract One of the endogenous estrogens, 17β-estradiol (E 2 ) is a female steroid hormone secreted from ovary. It well established that E causes biochemical and histological changes in uterus. The oviduct response to virtually unknown an vivo environment. In this study, we assessed effect on each oviductal cell type, using ovariectomized-hormone-replacement mouse model, single RNA-sequencing (scRNA-seq), situ hybridization, cell-type-specific deletion mice. We found type responded...