A5042193298- Infant Nutrition and Health
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Metabolism and Genetic Disorders
- Fatty Acid Research and Health
- Pregnancy and preeclampsia studies
- Child Nutrition and Water Access
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Infant Development and Preterm Care
- Growth Hormone and Insulin-like Growth Factors
- Neonatal and fetal brain pathology
- Cardiovascular Conditions and Treatments
- Gout, Hyperuricemia, Uric Acid
- Breastfeeding Practices and Influences
- Neonatal and Maternal Infections
- Bacterial Infections and Vaccines
- Genetics and Neurodevelopmental Disorders
- Sepsis Diagnosis and Treatment
- Renal and related cancers
- Eicosanoids and Hypertension Pharmacology
- Platelet Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Trace Elements in Health
Juntendo University
2014-2024
South Australian Health and Medical Research Institute
2024
Juntendo University Shizuoka Hospital
2018-2023
Tottori University
2000-2016
<b>Background:</b> Although urate impaired the endothelial function, its underlying mechanism remains unknown. We hypothesized that nitric oxide (NO) production in human umbilical vein cells (HUVECs) via activation of uric acid transporters (UATs). <b>Purpose and method:</b> In present study, we studied effects on NO eNOS protein expression HUVEC presence absence lowering agents using molecular biological biochemical assays. <b>Results:</b> HUVECs expressed 4 kinds UATs, URATv1, ABCG2, MRP4...
Abstract Kyphomelic dysplasia is a heterogeneous group of skeletal dysplasias characterized by severe bowing the limbs associated with other variable findings, such as narrow thorax and abnormal facies. We searched for genetic etiology this disorder. Four individuals diagnosed kyphomelic were enrolled. performed whole‐exome sequencing evaluated pathogenicity identified variants. All had de novo heterozygous variants in KIF5B encoding kinesin‐1 heavy chain: two c.272A>G:p.(Lys91Arg), one...
Abstract Background Given that preterm infants are born at a time of rapid fetal growth, they risk deficiency essential nutrients for brain development, including zinc (Zn) and copper (Cu). This study evaluate the relationship between serum Cu or Zn, gestational age ( GA ) anthropometric parameters birth in infants. Methods was retrospective <35 weeks’ from January 2010 to August 2012. We collected data medical records 59 with regard , parameters, Zn levels. Correlation Cu, then done....
Reactive oxygen species may be involved in serious diseases premature infants. The objective of this study was to assess the relationship between neurodevelopmental outcome and oxidative stress marker level urine very low-birthweight (VLBW) infants.Spot samples were collected from 35 VLBW Urinary excretion 8-hydroxy-2″-deoxyguanosine (8-OHdG), a DNA damage, 8-iso-prostaglandin F2α (8-isoPGF), lipid peroxidation, measured at 1, 2, 4, 6 weeks age. Neurodevelopmental 18 months' corrected age...
Evidence suggests that breastfeeding during infancy lowers the risk of metabolic syndrome (MS) and its attendant factors in adult life. To investigate influence feeding type on MS, we assessed insulin sensitivity lipid apolipoprotein metabolism preterm infants. Blood samples were collected from infants at time discharge. Infants separated into two groups: a breast milk (BM) group receiving ⩾90% their intake BM, mixed-fed (MF) ⩾50% formula. The following indices then compared between groups....
Abstract Objective: Little is known about physical constitution outcomes for very preterm infants. Here, we compare z-scores of anthropometric parameters up to 6 years age in children born with low birth weight (VLBW) at less than 30 weeks gestation, or without intrauterine growth restriction (IUGR). Design: Participants were divided into four subgroups: male (M), small gestational (SGA) ( n = 30); M, appropriate (AGA) 59); female (F), SGA 24); and F, AGA 61). z-Scores body (BW), length...
IGF1 is a key molecule in the regulation of growth and metabolism. Low secretion known to cause restriction childhood, as well deregulated lipid metabolism, cardiovascular disease, diabetes adulthood. The gene P2 promoter highly methylated, resulting low small infants children. However, it unknown when this methylation occurs. aim study was clarify point epigenetic program occurs during intrauterine development. We analyzed 56 preterm born before 32 weeks gestation, including 19 (IUGR) whose...
This study aimed to examine the nutritional effect of breast feeding on healthy term infants by using urinary metabolome analysis.Urine samples were collected from 19 and 14 at 1 6 months, respectively. Infants separated into two groups: breast-fed group receiving <540 mL/week their intake formula (n=13 month; n=9 months); formula-fed no milk (BM) (n=6 n=5 months). Urinary analysis was performed capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS).A total 29 metabolites...
Objective: This study was performed to examine the choline status on term and preterm infants using urinary metabolome analysis.Material methods: Samples were collected from 19 20 between 15 days 1 month, respectively. The separated into four groups: term-breast group (TB, n = 13), term-formula (TF, 6), preterm-breast (PB, 11), preterm-mixed (PM, 9). Urinary analysis capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS). We also of infant formulas.Results: excretion...
Aim Poor post‐natal growth is related to later morbidity and poor cognitive development in preterm infants. We investigated the relationship between plasma insulin‐like factor 1 ( IGF ‐1), leptin, active ghrelin levels infants small for gestational age SGA ). Methods Plasma ‐1, leptin were measured at birth 2, 4, 6 8 weeks after 42 very low birthweight VLBW ) (born 27 31 of gestation), including 14 with extrauterine restriction EUGR ), without 22 appropriate‐for‐gestational‐age Results At...
The development of neonatology has been associated with improved survival among infants born extremely preterm, and understanding their long-term outcomes is becoming increasingly important. However, there little information on body mass index (BMI) these children.To determine factors BMI at ages 18 months 36 preterm.This retrospective, multicenter cohort study was conducted using data from the Neonatal Research Network Japan database for 8838 gestational 23 to 28 weeks months. Data were...
Abstract Aim The metabolic changes that occur during the postnatal weaning period appear to be particularly important for future health, and breast milk is considered provide optimal source of infant nutrition. This pilot study from September 2013 May 2015 examined effect breastfeeding on prostaglandin metabolism in healthy term infants. Methods Urine samples were collected 19 infants at one month age Juntendo University Hospital, Tokyo, Japan. 13 breast‐fed group received less than 540...
To investigate the relationship between early-life stress and glucocorticoid receptor (GR) gene methylation, which may result in long-lasting neurodevelopmental impairment, we performed a longitudinal analysis of methylation ratio within GR promoter 1F region using next-generation sequencing preterm infants. Cell-free DNA was extracted from frozen serum 19 birth infants at 1 2 months after birth. All were admitted to neonatal intensive care unit Juntendo University Shizuoka Hospital August...
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the incretin hormones secreted from intestine in response to enteral feeding stimulate insulin secretion. We investigated relationship serum GIP GLP-1 levels with gestational age, secretion preterm infants. Serum were measured at birth 1, 2 4 weeks after 30 infants, including 12 born before 30th week of gestation (early group) 18 (late group). Blood glucose measured, quantitative sensitivity check...
Abstract Background Insulin‐like growth factor‐I (IGF‐I) is essential for perinatal and development; low serum IGF‐I has been observed during intrauterine restriction (IUGR). We investigated the effects of recombinant human (rh) in IUGR rats early postnatal period. Methods Intrauterine was induced by bilateral uterine artery ligation pregnant rats. pups were divided into two groups injected daily with rhIGF‐I (2 mg/kg; IUGR/IGF‐I, n = 16) or saline (IUGR/physiologic solution (PSS), from day...
Enterococcus faecalis is rarely involved in neonatal meningitis. Several studies have indicated that the cytokines related to bacterial infection may induce nerve cell damage; therefore, cytokine levels cerebrospinal fluid (CSF) could represent a valuable hallmark for rapid recognition of disease and evaluation degree neurological involvement. We analyzed CSF neonate with E. meningitis over time. Tumor necrosis factor-α (TNF-α) tended be elevated during acute phase infection, then decreased...
Several studies have reported association of altered levels lipids and some trace elements with risk factors for cardiovascular disease development in adulthood. Accordingly, the present study aimed to determine relationship among serum copper (Cu), zinc (Zn), lipids, lipoproteins apolipoproteins preterm infants through an assessment atherogenic indices shortly after birth. Blood samples were collected within 20 min birth from 45 gestational ages ranging 32 35 weeks. Serum Cu, Zn, total...
There is limited evidence on the association between clinical course of patent ductus arteriosus (PDA) and prostaglandin (PG) metabolites. This study aimed to determine influence PDA treatment urinary PG metabolite excretion in very-low-birth-weight (VLBW) infants.
Abstract Background Intrauterine growth restriction (IUGR) has been shown to be associated with increased risk of renal disease or hypertension in later life. Glomerular dysfunction, however, mainly reported, and limited information is available link IUGR tubular damage. The aim this study was therefore investigate urinary markers damage a rat model induced by bilateral uterine artery ligation. Methods Pregnant Sprague–Dawley rats underwent ligation, while the control group sham surgery....
<b>Background:</b> Besides its antiarrhythmic action, carvedilol has an activity to suppress cardiac tissue damage. However, it is unknown whether any effect on cellular apoptosis and ion channel remodelling. <b>Purpose:</b> To know remodeling of HL-1 cells expressing E334K MyBPC, comparing with bisoprolol. <b>Method:</b> We examined effects bisoprolol the levels pro- anti-apoptotic proteins channels as well transfected MyBPC using Western blot flow cytometry. <b>Results:</b> Carvedilol...