A5042677552- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Animal Behavior and Reproduction
- Gout, Hyperuricemia, Uric Acid
- Advanced Drug Delivery Systems
- Insect and Pesticide Research
- Neurobiology and Insect Physiology Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Drug Solubulity and Delivery Systems
- Alcohol Consumption and Health Effects
- Drug Transport and Resistance Mechanisms
- Hydrogels: synthesis, properties, applications
- Pharmacological Effects of Natural Compounds
- Insect symbiosis and bacterial influences
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Metabolism and Genetic Disorders
- Fossil Insects in Amber
- Conducting polymers and applications
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Systemic Sclerosis and Related Diseases
- Pharmaceutical studies and practices
- Liver Disease Diagnosis and Treatment
Tamagawa University
2017-2024
Tokyo Medical and Dental University
2024
Juntendo University
2022-2023
Okayama University
2016-2017
Hokkaido University
2005-2015
Tokyo Women's Medical University
2015
Kajima Corporation (Japan)
2012-2014
University of Toyama
2012-2014
University of Miyazaki
2010
Japan Society for the Promotion of Science
2010
Significance Gene duplication is a major source of evolutionary innovation and associated with the increases in biological complexity adaptive radiation. Termites are model social organisms characterized by sophisticated caste system. We analyzed genome Japanese subterranean termite, an ecologically economically important insect acting as destructive pest. The analyses revealed significance gene evolution. caste-biased expression was prevalent termite genome. Many duplicated genes were...
Abstract Background Numerous cases of predator-induced polyphenisms, in which alternate phenotypes are produced response to extrinsic stimuli, have been reported aquatic taxa date. The genus Daphnia (Branchiopoda, Cladocera) provides a model experimental system for the study developmental mechanisms and evolutionary processes associated with polyphenisms. In D. pulex , juveniles form neckteeth predatory kairomones released by Chaoborus larvae (Insecta, Diptera). Results Previous studies...
Abstract Eusocial insects exhibit various morphological castes associated with the division of labor within a colony. Termite soldiers possess defensive traits including mandibles that are greatly exaggerated and enlarged, as compared to termite reproductives workers. The enlarged known result from dynamic morphogenesis during soldier differentiation can be induced by juvenile hormone its analogs. However, detailed developmental mechanisms still remain unresolved. Because...
In social Hymenoptera with no morphological caste, a dominant female becomes an egg layer, whereas subordinates become sterile helpers. The physiological mechanism that links dominance rank and fecundity is essential part of the emergence females, which reflects primitive phase eusociality. Recent studies suggest brain biogenic amines are correlated ranks in hierarchy. However, actual causality between aminergic systems phenotype (i.e. aggressiveness) largely unknown due to pleiotropic...
Hypouricemia was reported as a risk factor for exercise-induced acute renal injury (EIAKI) and urinary stones. However, the prevalence of kidney diseases among hypouricemic subjects has not been evaluated. This study conducted to clarify hypouricemia association with by using large-scale Japanese population data.This is retrospective cross-sectional at Center Preventive Medicine, St. Luke's International Hospital, Tokyo, Japan, Sanin Rousai Yonago, Japan. We analyzed medical records 90,143...
<b>Background:</b> Although urate impaired the endothelial function, its underlying mechanism remains unknown. We hypothesized that nitric oxide (NO) production in human umbilical vein cells (HUVECs) via activation of uric acid transporters (UATs). <b>Purpose and method:</b> In present study, we studied effects on NO eNOS protein expression HUVEC presence absence lowering agents using molecular biological biochemical assays. <b>Results:</b> HUVECs expressed 4 kinds UATs, URATv1, ABCG2, MRP4...
Abstract Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) well controlled. Xanthine oxidoreductase inhibitors (XORi) reduce levels and have several other potential effects. This multicenter, randomized, open‐label study compared the effects of two XORi, topiroxostat febuxostat, on arterial stiffness, levels, BP hypertensive hyperuricemia. Patients received 40–160 mg/day or febuxostat 10–60 mg/day, titrated to maintain <6...
Most hymenopteran species exhibit conspicuous sexual dimorphism due to ecological differences between the sexes. As genomes, under haplodiploid genetic system, quantitative sexes while remaining qualitatively identical, phenotypes are assumed be expressed through sex-specific gene usage. In present study, molecular basis for expression of in a queenless ant, Diacamma sp., which exhibits distinct color dimorphism, was examined. Worker females appear bluish-black, winged males yellowish-brown...
The sex determination gene doublesex (dsx) encodes a transcription factor with two domains, oligomerization domain 1 (OD1) and OD2, is present throughout insects. Sex-specific Dsx splicing isoforms regulate the of target genes trigger differentiation in all Holometabola examined to date. However, some hemimetabolous insects, dsx not spliced sexually its sequence less conserved. Here, elucidate evolutionary changes organisation regulation termites, we searched genome and/or transcriptome...
Social communication among castes is a crucial component of insect societies. However, the genes involved in soldier determination through regulation inter-individual interactions are largely unknown. In an incipient colony damp-wood termite Zootermopsis nevadensis , first larva to develop into third instar always differentiates via frequent trophallactic feeding from reproductives. Here, by performing RNA-seq analysis larvae, homologue Neural Lazarillo (named ZnNLaz1 ) was found be most...
A case of infantile neuropathy with signs respiratory distress and impaired abdominal movements from the neonatal period was reported.Muscle biopsy revealed type II fiber predominance atrophy, sural nerve demonstrated absence myelin in almost all axons. Onion bulb formation or debris not observed. The features deficit without active breakdown onion formation, finding muscle pathology, indicating spinal muscular suggested that under study identical to hypomyelination neuropathy.
Eusocial insects such as termites, ants, bees, and wasps exhibit a reproductive division of labor. The developmental regulation organ (ovaries testes) is crucial for distinguishing between sterile castes. development in regulated by sex-determination pathways. sex determination gene Doublesex (Dsx), encoding transcription factors, plays an important role this pathway. Therefore, clarifying the function Dsx sexual traits to understand social evolution eusocial insects. However, no studies...
Caste polyphenism in social insects provides us with excellent opportunities to examine the plasticity and robustness underlying developmental pathways. Several ant species have evolved unusual castes showing intermediate morphologies between alate queens wingless workers. In some low-temperature habitats, Myrmecina nipponica produces such reproductives (i.e. ergatoids), which can mate store sperm but cannot fly. To gain insight into evolutionary aspects associated ergatoid production, we...