A5028461564- Gout, Hyperuricemia, Uric Acid
- Cardiac electrophysiology and arrhythmias
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Pulmonary Hypertension Research and Treatments
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- Urinary Bladder and Prostate Research
- Metabolomics and Mass Spectrometry Studies
- Receptor Mechanisms and Signaling
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Heart Failure Treatment and Management
- Ion Transport and Channel Regulation
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
Dokkyo Medical University
2007-2025
National Hospital Organization
2025
National Institute of Technology, Yonago College
2024-2025
Oita University
2017-2024
Tottori University Hospital
2024
Niigata University of Health and Welfare
2024
Oita University Hospital
2019-2023
<b>Background:</b> Although urate impaired the endothelial function, its underlying mechanism remains unknown. We hypothesized that nitric oxide (NO) production in human umbilical vein cells (HUVECs) via activation of uric acid transporters (UATs). <b>Purpose and method:</b> In present study, we studied effects on NO eNOS protein expression HUVEC presence absence lowering agents using molecular biological biochemical assays. <b>Results:</b> HUVECs expressed 4 kinds UATs, URATv1, ABCG2, MRP4...
The drug K201 (JTV-519) increases inotropy and suppresses arrhythmias in failing hearts, but the effects of on normal hearts is unknown.The effect excitation-contraction (E-C) coupling myocardium was studied by using voltage-clamp intracellular Ca(2+) measurements intact cells. Sarcoplasmic reticulum (SR) function assessed permeabilised cardiomyocytes.Acute application <1 micromol/L had no significant E-C coupling. at 1 decreased transient amplitude (to 83+/-7%) without affecting I(Ca,L) or...
Intracellular uric acid is known to increase the protein level and channel current of atrial Kv1.5; however, mechanisms acid-induced enhancement Kv1.5 expression remain unclear. Methods Results: The effects on mRNA levels Kv1.5, as well those Akt, HSF1 Hsp70, in HL-1 cardiomyocytes were studied by using qRT-PCR Western blotting. uptake was measured radio-labeled acid. Kv1.5-mediated also patch clamp techniques. Uric up-taken cells significantly increased proteins a concentration-dependent...
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among all infants worldwide and remains a significant morbidity mortality. To address this unmet medical need, MK-1654, half-life extended RSV neutralizing monoclonal antibody, in clinical development for prevention disease infants. This was phase I, randomized, placebo-controlled, single-site, double-blind trial MK-1654 44 healthy Japanese adults. The safety, tolerability, pharmacokinetics, antidrug...
Intermittent claudication is a major barrier to establishing an exercise routine in patients with peripheral artery disease (PAD). This study investigated the preconditioning effects of neuromuscular electrical stimulation (NMES) on walking capacity PAD and intermittent claudication. Additionally, it aimed determine optimal NMES settings underlying mechanisms its effects. A total 15 (Fontaine II) participated crossover study. Each patient underwent 10-min sessions at two frequencies (4 20...
The Japanese Society of Gout, Uric, and Nucleic Acid developed the Guideline for Management Hyperuricemia Gout (JGMHG) third edition, which contains seven clinical questions (CQs) corresponding recommendations. Questionnaire surveys were conducted to clarify how recommendations regarding CQs influence decision-making in practice. surveillances twice 2018, just after publication JGMHG, 2020, 2 years later. participants members Acid. While 2018 contained questionnaires on as well three status...
Cancer-related venous thromboembolism (VTE) is a significant concern owing to its frequent occurrence and status as leading cause of death in patients with cancer. VTE carries higher risk hemorrhage than without carcinoma. A 74-year-old woman pancreatic head cancer presented complaints loss appetite weight loss. Contrast-enhanced computed tomography (CT) was performed for stage classification cancer, which incidentally revealed pulmonary thromboembolism. The patient remained clinically...
Background Belt electrode skeletal muscle stimulation (B-SES) is an alternative exercise therapy for those with difficulty performing voluntary exercise. However, it unknown whether oxygen uptake (VO2) in B-SES comparable to cardiopulmonary test (CPX) as assessed by This study aimed evaluate and lactate (LA) production incremental compared ergometer CPX determine the relationship CPX. Methods included 10 healthy young Japanese participants. Using a crossover design, all participants...
K201 has previously been shown to reduce diastolic contractions in vivo during β-adrenergic stimulation and elevated extracellular calcium concentration ([Ca(2+)](o)). The present study characterised the effect of on electrically stimulated spontaneous sarcoplasmic reticulum (SR)-mediated Ca(2+) release contractile events isolated rat cardiomyocytes [Ca(2+)](o). Parallel experiments using confocal microscopy examined at an enhanced spatiotemporal resolution. 1.0 μmol/L presence 150 nmol/L...
Ischemia/reperfusion (I/R) injury triggers cardiac dysfunctions via creating reactive oxygen species (ROS). Because xanthine oxidase (XO) is one of the major enzymes that generate ROS, inhibition XO expected to suppress ROS-induced I/R injury. However, it remains unclear whether really yields cardioprotection during I/R. The protective effects inhibitors, topiroxostat and allopurinol, on were evaluated.Methods Results:Using isolated rat hearts, ventricular functions, occurrence arrhythmias,...
The purpose of this study was to create novel urate under-excretion animal models using pyrazinamide and evaluate whether dihydropyridine calcium channel blockers (CCBs) have uricosuric effects in vivo. Adult male ICR mice were treated with pyrazinamide, vehicle (dimethyl sulfoxide: DMSO), or tap water. Thirty minutes later, pyrazinamide-treated given benzbromarone, losartan, nilvadipine, nitrendipine, nifedipine azelnidipine. Six hours after the second administration, urine (by urinary...
Background: The low implementation rate of guideline-directed medical therapy for heart failure (HF) remains a problem worldwide. To address this issue, we hypothesized that smartphone application (app) based on behavioral economics nudges physicians and patients towards optimal would be scalable approach.