A5100682435- Biosimilars and Bioanalytical Methods
- Protein purification and stability
- Coal Combustion and Slurry Processing
- Thermochemical Biomass Conversion Processes
- Autophagy in Disease and Therapy
- Identification and Quantification in Food
- Immunotherapy and Immune Responses
- Thermal and Kinetic Analysis
- Microscopic Colitis
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Bowel Disease
- Aquaculture disease management and microbiota
- Cytomegalovirus and herpesvirus research
- Coal and Its By-products
- Hepatitis B Virus Studies
- Toxoplasma gondii Research Studies
- Immune Cell Function and Interaction
- Oral microbiology and periodontitis research
- Vibrio bacteria research studies
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
Jeonbuk National University
2014-2023
Pusan National University Hospital
2020
Celltrion (South Korea)
2016-2018
Case Western Reserve University
2017
University School
2017
Pukyong National University
2013
CT-P10 (Truxima™) was recently approved as the world's first rituximab biosimilar product in European Union (EU) and South Korea. To demonstrate biosimilarity of with reference medicinal (RMP), extensive 3-way similarity assessment has been conducted between CT-P10, EU-Rituximab US-Rituximab, focusing on physicochemical biological quality attributes. A multitude state-of-the-art analyses revealed that identical primary higher order structures compared to original product. Purity/impurity...
Targeting of Toxoplasma gondii by autophagy is an effective mechanism which host cells kill the protozoan. Thus, parasite must avoid autophagic targeting to survive. Here we show that mammalian cytoplasmic molecule Focal Adhesion Kinase (FAK) becomes activated during invasion cells. Activated FAK appears accompany formation moving junction (as assessed expression protein RON4). activation was inhibited approaches impaired β1 and β3 integrin signaling. caused Src in turn mediated Epidermal...
Abstract Background High-grade serous carcinoma (HGSC) of the ovary is most common subtype epithelial ovarian cancer (EOC) and has an overall poor prognosis. There increasing awareness importance immune cell populations tumor-infiltrating lymphocytes (TILs) in various pathways tumor microenvironment. The present study evaluated immune-related gene expressions TIL levels, as well associated chemotherapeutic responses, to elucidate correlation between expression levels HGSC. Materials methods...
CT-P13 is the first biosimilar monoclonal antibody to infliximab, and was recently approved in European Union, Japan, Korea, USA for all six indications of infliximab. However, studies directly assessing biologic activity versus inflximab context inflammatory bowel disease [IBD] are still scanty. In present study, we aimed compare biological activities infliximab with specific focus on intestinal cells so as gain insight into potential biosimilarity these two agents treatment IBD.CT-P13 were...
In this study, the catalytic effects of impregnated catalysts K2CO3, alkali earth, and transition metal salts in lignite-CO2 gasification were investigated. The experiments conducted over a temperature range 800–900 °C at atmospheric pressure. Catalysts such as Ca(OH)2, CaCO3, Ce(NO3)3, Fe(NO3)3 on Mongolia coal using aqueous solutions rotary evaporator. modified volumetric reaction model gas-solid was applied to experimental data obtain kinetic information. activity single followed sequence...
최근 울산광역시 소재의 넙치 양식장에서 체색 흑화, 간 위축, 장관 백탁 등의 증상을 보이며 넙치의 대량 폐사가 빈번히 발생하여, 병원체를 분리하고 감염 특성에 관하여 연구하였다. 2012년 5월 병어로부터 분리한 원인균은 생화학 시험과 16S rRNA, dnaJ gene을 이용한 염기서열 분석을 통해 V. scophthalmi로 동정하였다. 병원성 시험 결과, 본 균주가 <TEX>$10^6$</TEX> CFU/fish에서 75%의 누적 폐사율을 보여 강한 병원성이 확인되었다. scophthalmi 감염어는 조직병리학적 병변으로서 장 상피 탈락, 장내 세포 물질 유출 및 장관백탁증 등이 Recently high mortality of cultured olive flounder, Paralichthys olivaceus occurred frequently at the fish farms in Ulsan, Korea. The diseased showed skinny body...
We performed the steam gasification of lignite char physically mixed with three kinds waste catalysts obtained from hydrotreating process petroleum plants. Steam and K2CO3 was investigated on a fixed bed reactor gas chromatography analyzer at temperature range 800–900 °C. The reaction rate, carbon conversion maximum release rate major gases increased increasing temperature. conversions were more than 90% similar to K2CO3. higher index largest H2 gross production, 203.3 mmol/gc, observed...
Abstract Background There are reports of false qualitative HBsAg results because several causes, such as samples with low concentrations that may produce positives. The main aims this study to validate the analytical accuracy and operational cutoff value Elecsys II Quant assay. secondary goal is assess role assay in resolving equivocal quali-tative compared those medical laboratory. Methods limit blank (LoB), detection (LOD), quantification (LoQ), linearity were first estimated To according...