A5043570761- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Mass Spectrometry Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Extracellular vesicles in disease
- Inflammatory Bowel Disease
- Molecular Biology Techniques and Applications
- Immune Response and Inflammation
- Lipid metabolism and biosynthesis
Health Research Institute of the Balearic Islands
2019-2025
Hospital Universitario Son Espases
2021-2024
Glioblastoma (GBM) represents one of the deadliest tumors owing to a lack effective treatments. The adverse outcomes are worsened by high rates treatment discontinuation, caused severe side effects temozolomide (TMZ), reference treatment. Therefore, understanding TMZ’s on GBM and healthy brain tissue could reveal new approaches address chemotherapy effects. In this context, we have previously demonstrated membrane lipidome is highly cell type-specific very sensitive pathophysiological...
Even though colorectal cancer (CRC) is one of the most preventable cancers, it deadliest, and recent data show that incidence in people <50 years has unexpectedly increased. While new techniques for CRC molecular classification are emerging, no feature as yet firmly associated with prognosis. Imaging mass spectrometry (IMS) lipidomic analyses have demonstrated specificity lipid fingerprint differentiating pathological from healthy tissues. During IMS analysis, formation ionic adducts...
Macrophages (Mφ) are immune cells that play a crucial role in both innate and adaptive immunity as they involved wide range of physiological pathological processes. Depending on the microenvironment signals present, Mφ can polarize into either M1 or M2 phenotypes, with macrophages exhibiting pro-inflammatory cytotoxic effects, while having immunosuppressive tissue repair properties. have been shown to key roles development progression inhibition various diseases, including cancer. For...