A5044195260- Sinusitis and nasal conditions
- Atrial Fibrillation Management and Outcomes
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Allergic Rhinitis and Sensitization
- Infectious Diseases and Mycology
- Wireless Body Area Networks
- Inflammasome and immune disorders
- Cardiovascular Disease and Adiposity
- Obstructive Sleep Apnea Research
- Meningioma and schwannoma management
- Meat and Animal Product Quality
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Takotsubo Cardiomyopathy and Associated Phenomena
St. Josef-Hospital
2025
St. Josefs Hospital
2025
Witten/Herdecke University
2022-2024
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2023
West German Heart and Vascular Center Essen
2018-2020
University of Duisburg-Essen
2017-2018
Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome mediates caspase-1 activation interleukin-1β release in immune cells but not known to play a role cardiomyocytes (CMs). Here, we assessed the of CM AF.
Postoperative atrial fibrillation (POAF) is a common and troublesome complication of cardiac surgery. POAF generally believed to occur when postoperative triggers act on preexisting vulnerable substrate, but the underlying cellular molecular mechanisms are largely unknown.To identify in right samples from patients without history undergoing open-heart surgery.Multicellular action potentials, membrane ion-currents (perforated patch-clamp), or simultaneous membrane-current (ruptured...
Introduction In the case of recurrence CRSwP, there is option revision sinus surgery (RSS) vs. biologica therapy. This raises question extent to which ethmoid bone cells (EBC) are still present despite previous surgery. These may be a contributory factor in exacerbating local Th2-inflammation. study, EBC were left place and not removed operations was investigated. For this purpose, score developed assess CT-NNH findings after
Einleitung Beim Rezidiv der CRSwP gibt es die Option Re-NNH-OP vs. Biologika-Therapie. Hier stellt sich Frage, inwieweit trotz vorangegangener NNH-OP Siebbeinzellen (SBZ) weiterhin vorhanden sind. Diese können mitursächlich sein, lokale Th2-Inflammation zu verschlimmern. In vorliegenden Studie wurde untersucht, SBZ in vorangegangenen Operationen belassen und nicht entfernt wurden. Hierzu ein Score zur Beurteilung CT-NNH Befunde bei Z.n. Vor-OP entwickelt.
Introduction Curative DTT represents an ENT medical challenge. In addition to close cooperation with the radiation therapists, management of side effects must be so effective that, on one hand, few interruptions are necessary and, other desired cumulative dose cisplatin is achieved. Particularly in multimorbid patients, question arises what extent can guaranteed by sole care.
Einleitung Die kurative MT stellt eine HNO-ärztliche Herausforderung dar. Neben der engen Kooperation mit den Strahlentherapeuten muss das Management Nebenwirkungen so effektiv sein, dass möglichst wenig Unterbrechungen Radiatio notwendig werden und die angestrebte Cisplatin-Kumulativdosis erreicht wird. Insbesondere bei multimorbiden Patienten sich Frage, inwieweit durch alleinige Versorgung gewährleistet kann.
Background Chronic rhinosinusitis with nasal polyps is commonly caused by a complex Th-2 cell-based inflammatory response in Western countries. However, the exact pathomechanism still largely unknown. In order to enable further sufficient investigations and new insights, it necessary develop an investigation tool that can reflect this complexity. Research question present study, potential of organ culture tissue from as was evaluated.
Hintergrund Die chronische Rhinosinusitis mit Nasenpolypen wird in den westlichen Ländern häufig durch eine komplexe, auf Th-2-Zellen basierende Entzündungsreaktion verursacht. Der genaue Pathomechanismus ist jedoch noch weitgehend unbekannt. Um weitergehende suffiziente Untersuchungen und neue Erkenntnisse ermöglichen zu können, es erforderlich, ein Untersuchungsinstrument entwickeln, welches diese Komplexität widerspiegeln kann.
Background: Inflammation is a known risk factor of atrial fibrillation (AF), the most common arrhythmia; however, mechanistic link between inflammatory signaling and pathophysiology AF has not been established. ‘NACHT, LRR PYD domains-containing protein 3’ (NLRP3) inflammasome platform that responsible for activation caspase-1 interleukin (IL)-1b release. The activity NLRP3 enhanced in tissues paroxysmal or long-lasting persistent patients. Thus, we tested hypothesis promotes development AF....
Post-operative atrial fibrillation (poAF) is the most common perioperative arrhythmia associated with increased hospital morbidity and mortality. It known that myocyte Ca 2+ handling changes can play a crucial role in AF pathogenesis, although specific mechanisms involved poAF have not been elucidated. Our lab has previously identified Striated Muscle Preferentially Expressed Protein Kinase (SPEG) as binding partner of major cardiac release channel RyR2 its negative regulator JPH2, which are...
Introduction Intracranial tumor resection using an ultrasonic aspirator are well established in neurosurgery. Ultrasonic aspirators use frequency vibrations generated by a piezoelectric element the handpiece to remove tissue. In present study, of frontal skull base is reported.
Einleitung Tumorresektionen im Cranium mittels Ultraschallaspirator sind in der Neurochirurgie etabliert. Ultraschallaspiratoren verwenden Ultraschallfrequenzvibrationen, die von einem piezoelektrischen Element Handstück erzeugt werden, um Gewebe zu entfernen. In vorliegenden Untersuchung wird Resektion eines Frontobasistumors Ultaschallaspirator berichtet.