A5000267996- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Bone health and osteoporosis research
- Urological Disorders and Treatments
- Pressure Ulcer Prevention and Management
- Bone health and treatments
- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Nutrition and Health in Aging
- Anorectal Disease Treatments and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Angiogenesis and VEGF in Cancer
- Hip and Femur Fractures
- Intensive Care Unit Cognitive Disorders
- Thermoregulation and physiological responses
- Prostate Cancer Treatment and Research
- Menopause: Health Impacts and Treatments
- Stoma care and complications
- Bone and Joint Diseases
- Aging, Elder Care, and Social Issues
- Bone Metabolism and Diseases
- Sleep and related disorders
- Prostate Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
University of Pittsburgh
2015-2024
University of Pittsburgh Medical Center
2004-2023
Institute on Aging
1998-2019
Magee-Womens Hospital
2015-2016
Brigham and Women's Hospital
1995-2011
National Institutes of Health
2007-2011
Pittsburg State University
2011
Geriatric Research Education and Clinical Center
1989-2010
National Institute on Aging
1998-2010
North Florida/South Georgia Veterans Health System
2010
Delirium (or acute confusional state) affects 35% to 65% of patients after hip-fracture repair, and has been independently associated with poor functional recovery. We performed a randomized trial in an orthopedic surgery service at academic hospital determine whether proactive geriatrics consultation can reduce delirium hip fracture.Prospective, randomized, blinded.Inpatient tertiary medical center.126 consenting 65 older (mean age 79 +/- 8 years, 79% women) admitted emergently for surgical...
To evaluate the role of delirium in natural history functional recovery after hip fracture surgery, independent prefracture status.Prospective cohort study.Orthopedic surgery service at a large academic tertiary hospital, with follow-up extending into rehabilitation hospitals, nursing homes, and community.One hundred twenty-six consenting subjects older than 65 years (mean age 79 +/- 8 years, 79% women) admitted emergently for surgical repair fracture.Detailed assessment enrollment to...
The endothelial lining of blood vessels is constantly exposed to fluid mechanical forces generated by flowing blood. In vitro application shear stresses cultured cells influences the expression multiple genes, as reflected changes in their steady-state mRNA levels. We have utilized B chain platelet-derived growth factor (PDGF-B) a model investigate mechanisms shear-stress-induced gene regulation bovine aortic (BAECs). Northern blot analysis revealed elevated endogenous PDGF-B transcript...
Hemodynamic forces induce various functional changes in vascular endothelium, many of which reflect alterations gene expression. We have recently identified a cis-acting transcriptional regulatory element, the shear stress response element (SSRE), present promoters several genes, that may represent common pathway by biomechanical influence In this study, we examined effect on endothelial expression three adhesion molecules: intercellular molecule-1 (ICAM-1), contains SSRE its promoter, and...
Little is known about the causes of urinary incontinence in institutionalized elderly people, despite fact that $8 billion annually devoted to diapering those afflicted. We have identified a specific physiological abnormality— detrusor hyperactivity with impaired contractile function (DHIC)—that, although previously unrecognized, second most common (33%) cause this setting. Detrusor distinct subset hyperreflexia and presents seemingly paradoxical set findings: bladder overactive but empties...
Although 1 million institutionalized elderly persons have urinary incontinence, little is known about the causes of this problem. We conducted clinical and physiologic studies to determine established incontinence in a representative sample 605 (mean age, 89 years), whom 40 percent were chronically incontinent urine. Detailed urodynamic 94 245 patients (77 women 17 men; 38 percent) showed that detrusor overactivity was predominant cause 61 percent, with concomitant impaired contractility...
Context: Although androgen deprivation therapy (ADT) for prostate cancer is associated with bone loss, little known about when this loss occurs. Objective: We postulated that men on ADT would experience the greatest acutely after initiation of ADT. Design and Setting: conducted a 12-month prospective study at an academic medical center. Patients or Other Participants: studied 152 (30 acute ADT, <6 months; 50 chronic ≥6 72 no ADT) 43 healthy age-matched controls. Main Outcome Measures:...
Background: Androgen deprivation therapy (ADT) in men with prostate cancer is associated bone loss and fractures. Objective: To determine whether once-weekly oral bisphosphonate can prevent reduce turnover receiving ADT. Design: Randomized, double-blind, placebo-controlled, partial crossover trial. First-year, preplanned analysis of a 2-group, parallel-design phase. Setting: University medical center. Patients: 112 nonmetastatic Intervention: Alendronate, 70 mg once weekly, or placebo. All...
Injuries from falls are major contributors to complications and death in older adults. Despite evidence efficacy trials that many can be prevented, rates of resulting injury have not declined.
Hemodynamic forces, such as fluid shear stress, that act on the endothelial lining of cardiovascular system can modulate expression an expanding number genes crucial for homeostasis and pathogenesis vascular disease. A 6-bp core element (5'-GAGACC-3'), defined previously a shear-stress response is present in promoters many genes, including PDGF B-chain, whose modulated by stress. The identity nuclear protein(s) binding to this has not yet been elucidated. Using electrophoretic mobility shift...
To validate the Memorial Delirium Assessment Scale (MDAS) as a measure of delirium severity in cohort patients aged 65 and older; to examine association between patient outcomes; psychomotor variants each those outcomes.Prospective assessment sample.Hospital.One hundred twenty-two older (mean age +/- standard deviation = 79 8) who had undergone acute hip fracture surgery.We used standardized instruments assess prefracture activities daily living (ADLs), ambulatory status, cognition,...
No AccessJournal of Urology1 Nov 1993Structural Basis Geriatric Voiding Dysfunction. II. Aging Detrusor: Normal Versus Impaired Contractility Ahmad Elbadawi, Subbarao V. Yalla, and Neil M. Resnick ElbadawiAhmad Elbadawi , YallaSubbarao Yalla ResnickNeil View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35867-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Little information on the structural norm aging...
No AccessJournal of Urology1 Nov 1993Structural Basis Geriatric Voiding Dysfunction. III. Detrusor Overactivity Ahmad Elbadawi, Subbarao V. Yalla, and Neil M. Resnick ElbadawiAhmad Elbadawi More articles by this author , YallaSubbarao Yalla ResnickNeil View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35868-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail overactivity in the absence outlet obstruction is...
No AccessJournal of UrologyAdult Urology: Voiding Dysfunction1 Nov 2005BRAIN CONTROL OF NORMAL AND OVERACTIVE BLADDER DEREK GRIFFITHS, STUART DERBYSHIRE, ANDY STENGER, and NEIL RESNICK GRIFFITHSDEREK GRIFFITHS More articles by this author , DERBYSHIRESTUART DERBYSHIRE STENGERANDY STENGER RESNICKNEIL View All Author Informationhttps://doi.org/10.1097/01.ju.0000177450.34451.97AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked...
No AccessJournal of Urology1 Nov 1993Structural Basis Geriatric Voiding Dysfunction. IV. Bladder Outlet Obstruction Ahmad Elbadawi, Subbarao V. Yalla, and Neil M. Resnick ElbadawiAhmad Elbadawi , YallaSubbarao Yalla ResnickNeil View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35869-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Several aspects the pathogenesis voiding dysfunction in bladder outlet...
Abstract Wall shear stress has been implicated in the genesis of atherosclerosis because a strong correlation exists between location developing arterial lesions and regions where particular gradients occur. Studying behavior endothelial cells such may contribute to our understanding disease etiology. We report detailed migratory history subjected large caused by surface protuberance an vitro model system. The cell migration, division, loss from was continuously monitored confluent human...
OBJECTIVES: To identify age‐associated changes in female lower urinary tract function across a wide age spectrum, controlling for detrusor overactivity (DO). DESIGN: Secondary analysis of cross‐sectional study DO and aging. Eligible volunteers were stratified by group presence DO. SETTING: Community‐based volunteers, evaluated research laboratory. PARTICIPANTS: Eighty‐five ambulatory, nondemented, community‐dwelling with without bladder symptoms suggestive DO, recruited advertising, mean 54...
We have examined functions of the cytoplasmic domain E-selectin, an inducible endothelial transmembrane protein, especially its ability to associate with cytoskeleton during leukocyte adhesion. Confocal microscopy interleukin-1 beta (IL-1 beta)-activated human umbilical vein cells (HUVEC) visualized clustering E-selectin molecules in vicinity leukocyte-endothelial cell attachment sites. A detergent based extraction and Western blotting procedure demonstrated association insoluble...
Eighty-five percent of institutionalized elderly people have osteoporosis and bone fracture rates 8 to 9 times higher than observed among community-dwelling people. Nevertheless, most these persons are left untreated excluded from pivotal trials.To determine the efficacy safety zoledronic acid treat in frail women long-term care facilities.We conducted a 2-year, randomized, placebo-controlled, double-blinded study December 2007 through March 2012. Included were 181 65 or older with...