A5042992461- Bladder and Urothelial Cancer Treatments
- Cancer Risks and Factors
- Pelvic floor disorders treatments
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Urinary Tract Infections Management
- Cancer, Lipids, and Metabolism
- Pressure Ulcer Prevention and Management
- Endometrial and Cervical Cancer Treatments
- Pharmaceutical Practices and Patient Outcomes
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Metabolism, Diabetes, and Cancer
- Body Contouring and Surgery
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Chronic Kidney Disease and Diabetes
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- Stoma care and complications
- Lung Cancer Treatments and Mutations
RTI International
2024
Kaiser Permanente
2013-2024
Pasadena City College
2018
National Institutes of Health
2007-2010
National Cancer Institute
2007-2010
Vanderbilt University Medical Center
2010
Brigham and Women's Hospital
2006-2009
Harvard University
2006-2009
AARP
2009
University Hospital Regensburg
2009
Pulmonary nodules are common incidental findings, but information about their incidence in the era of computed tomography (CT) is lacking.To examine recent trends pulmonary nodule identification.We used electronic health records and natural language processing to identify members an integrated system who had measuring 4 30 mm. We calculated rates chest CT imaging, identification, receipt a new lung cancer diagnosis within 2 years standardized by age sex estimate frequency identification U.S....
Abstract BACKGROUND: Convincing epidemiologic evidence links excess body mass to increased risks of endometrial and postmenopausal breast cancers, but the relation between index (BMI) ovarian cancer risk remains inconclusive. Potential similarities regarding a hormonal mechanism in etiology female cancers highlight importance investigating associations according menopausal hormone therapy (MHT) use. However, authors' knowledge, data addressing whether BMI differs by MHT use are very sparse....
To describe the relations between body mass index (BMI; kg/m(2)), weight gain, and incident urinary incontinence in middle-aged women.This was a prospective study Nurses' Health Study II. Participants reported their at age 18 years, current height 1989; updated on subsequent biennial questionnaires. From 2001-2003, cases with least monthly were identified among 30,982 women aged 37 to 54 years who no 2001. Information type collected from weekly incontinence. Multivariable-adjusted odds...
In Brief OBJECTIVE: To examine the association between physical activity and risk of developing urinary incontinence (UI). METHODS: Prospective analysis from Nurses' Health Study women aged 54–79 years. Physical was reported in 1986 biennially afterward. determine stable, long-term levels, data were averaged across all questionnaires (bottom quintile: 6.2 metabolic equivalent task hours per week or less; top more than 28.6 week). From 2000 to 2002, 2,355 cases incident UI identified using...
To improve the understanding of etiological relation between type 2 diabetes and urinary incontinence, we examined associations incontinence in 71,650 women 37 to 79 years old Nurses' Health Study II.From 1976 2000 1989 2001 II participants reported diagnoses diabetes. Women with incident at least weekly were identified from 2002 2003 II. We pooled data cohorts, estimated odds ratios 95% confidence intervals using multivariable logistic regression adjusting for age, parity, body mass index,...
The relationship between postmenopausal hormone use (PMH) and ovarian cancer risk is unclear, particularly for specific formulations, but recent studies suggest that there a positive association. We conducted prospective observational study with 82 905 women, including 389 cancers, in the Nurses' Health Study from 1976 to 2002. Compared never users of PMH, both current past ⩾5 years had significantly elevated (RR=1.41, 95% confidence interval (CI) 1.07–1.86 relative (RR)=1.52, CI 1.01–2.27,...
A history of diabetes has been fairly consistently related to a reduced prostate cancer risk, but previous investigations have not always addressed whether the relation with varies by aggressiveness or association between and is modified physical activity level body mass, variables closely glucose metabolism.We prospectively examined diabetes-prostate risk relationship among 33,088 men in screening arm Prostate, Lung, Colorectal Ovarian (PLCO) Cancer Screening Trial.During 8.9 years...
Abstract Biliary tract cancers, encompassing the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, predominant risk factor for biliary linked with hyperlipidemia. As part a population‐based case‐control study conducted in Shanghai, China, we examined associations serum lipid levels stones cancers. We included 460 cancer cases (264 141 duct, 55 Vater), 981 stone 858 healthy individuals randomly selected from population. Participants...
While strenuous, high impact activity may provoke urinary incontinence, little is known about relations with moderate physical activity. We examined recreational and incident incontinence in middle-aged women.This a prospective study of women 37 to 54 years old the Nurses' Health Study II. Repeated reports from 1989 2001 were averaged estimate long-term levels. From 2003 we identified 4,081 cases at least monthly incontinence. Incontinence type was further determined among weekly...
Although androgens may play an etiologic role in breast, ovarian and endometrial cancers, little is known about factors that influence circulating androgen levels. We conducted a cross-sectional analysis among 646 postmenopausal women the Nurses' Health Study to examine associations between adult risk for cancer, including Rosner/Colditz breast cancer score, plasma levels of testosterone, free androstenedione, dehydroepiandrosterone (DHEA) DHEA sulfate (DHEAS). All analyses were adjusted...
A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some dietary intake genetic polymorphisms the receptor. However, few have examined association circulating 25-hydroxyvitamin (25(OH)D), an integrated measure status, with risk. nested case-control study was conducted among 7 prospective to evaluate 25(OH)D concentration relation epithelial Logistic regression models were used estimate odds ratios 95%...
Efforts to improve patient safety have largely focused on inpatient or emergency settings, but the importance of in ambulatory care is increasingly being recognized as a key component overall health quality. Care gaps outpatient settings may include missed diagnoses, medication errors, insufficient monitoring patients with chronic conditions certain medications. Further, occur across wide range clinical conditions. We report here an innovative approach - Kaiser Permanente Southern California...
The relationship between cigarette smoking and breast cancer risk has been inconsistent, potentially due to modification by other factors or confounding. We examined in a prospective cohort of 186 150 female AARP (formerly American Association Retired Persons) members, ages 50–71 years, who joined the study 1995–96 responding questionnaire. Through 2006, 7481 cancers were diagnosed. Multivariable-adjusted hazard ratios (HRs) estimated, overall stratified factors, using Cox proportional...
Patients who undergo cystectomy due to bladder cancer can elect an ileal conduit or a neobladder for urinary diversion. Decision regret related this choice is important and undesirable patient reported outcome. Our objective was compare the severity of decision experienced by patients with vs conduit.We analyzed data from longitudinal cohort study underwent 2013 2015. We applied multivariable linear regression examine associations diversion method (neobladder conduit) measured DRS (Decision...
Women using unopposed estrogens during menopause are at increased risk of ovarian cancer. It is uncertain whether oestrogen plus progestin therapy exerts similar effects. We evaluated menopausal hormone use and incident cancer (n=426) in 92 601 post-menopausal women enrolled the National Institutes Health-AARP (NIH-AARP) Diet Health Study. Participants were administered questionnaires 1996–1997 followed through 2006. Hazard rate ratios (RR) 95% confidence intervals (CIs) estimated Cox...
Abstract Cruciferous vegetables are primary sources of dietary isothiocyanates (ITCs), a group phytochemicals showing promising cancer‐chemopreventive activities in multiple cancer models. However, no study has thoroughly examined how cooking affects the yields ITCs from cruciferous vegetables. In this study, high‐performance liquid chromatography (HPLC)‐based cyclocondensation assay was performed to examine ITC four major (broccoli, cabbage, cauliflower, and kale) under six conditions...
Abstract BACKGROUND Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but relationship between TNF variants and remains unclear. METHODS We examined associations six single nucleotide polymorphisms (SNPs) (rs1799964, rs1800630, rs1799724, rs1800629, rs361525, rs1800610) risk among 2,321 cases 2,560 controls from two nested case‐control studies within Prostate, Lung, Colorectal, Ovarian Cancer...
OBJECTIVE To examine whether use of insulin glargine, compared with another long-acting insulin, is associated risk breast, prostate, colorectal cancer, or all cancers combined. RESEARCH DESIGN AND METHODS Computerized health records from Kaiser Permanente Northern and Southern California regions starting in 2001 ending 2009 were used to conduct a population-based cohort study among patients diabetes aged ≥18 years. With Cox regression modeling, cancer users glargine (n = 27,418) was NPH...
Chronic inflammation has been hypothesized to increase prostate cancer risk. Prostaglandin-endoperoxide synthase 2 ( PTGS2 ) encodes the proinflammatory cyclooxygenase enzyme believed be rate-limiting step in synthesis of prostaglandins, important mediators inflammation. We investigated associations between polymorphisms and risk among 2321 cases 2560 controls two large case–control studies nested within Prostate, Lung, Colorectal Ovarian (PLCO) Cancer Screening Trial Prevention Study II...