A5026609544- Bladder and Urothelial Cancer Treatments
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Urinary and Genital Oncology Studies
- RNA Research and Splicing
- Immune cells in cancer
- Colorectal Cancer Surgical Treatments
- Moringa oleifera research and applications
- Mycotoxins in Agriculture and Food
- Circular RNAs in diseases
- Estrogen and related hormone effects
- Diet and metabolism studies
- Head and Neck Cancer Studies
- Advanced oxidation water treatment
- Sulfur Compounds in Biology
- Free Radicals and Antioxidants
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Copper-based nanomaterials and applications
- Colorectal Cancer Screening and Detection
- Drug-Induced Hepatotoxicity and Protection
- Advanced Photocatalysis Techniques
- Silymarin and Mushroom Poisoning
- Cardiac, Anesthesia and Surgical Outcomes
Roswell Park Comprehensive Cancer Center
2020-2024
Northeast Agricultural University
2024
Lanzhou University
2013-2023
First Hospital of Lanzhou University
2013-2023
Importance Tobacco smoking is an established risk factor associated with bladder cancer, yet its impact on cancer prognosis unclear. Objective To examine associations of use tobacco (cigarettes, pipes, and cigars), e-cigarettes, marijuana recurrence progression non–muscle-invasive (NMIBC) to explore cessation interventions. Design, Setting, Participants The Be-Well Study a prospective cohort study patients NMIBC diagnosed from 2015 2019 followed-up for 26.4 months in the Kaiser Permanente...
Abstract Cruciferous vegetables are primary sources of dietary isothiocyanates (ITCs), a group phytochemicals showing promising cancer‐chemopreventive activities in multiple cancer models. However, no study has thoroughly examined how cooking affects the yields ITCs from cruciferous vegetables. In this study, high‐performance liquid chromatography (HPLC)‐based cyclocondensation assay was performed to examine ITC four major (broccoli, cabbage, cauliflower, and kale) under six conditions...
Dietary isothiocyanates (ITCs) from cruciferous vegetables have shown potent anti-breast cancer activities in preclinical models, but their anticancer effects vivo breast patients remain elusive. A proof-of-principle, presurgical window of opportunity trial is conducted to assess the dietary ITCs patients.
As one of the 10 most common cancers in United States, bladder cancer is expensive to treat. Most (70%-80%) are diagnosed at early stages as non-muscle-invasive (NMIBC), which can be removed. However, 50% 80% NMIBC recurs within 5 years, and 15% 30% progresses with poor survival. Besides life-long surveillance, current treatment limited. Preclinical epidemiologic evidence suggest that dietary isothiocyanates (ITCs) cruciferous vegetables (Cruciferae) could a noninvasive cost-effective...
Accumulating evidence insists that circular RNAs (circRNAs) play important roles in the development of human cancers, including gastric cancer. This study aimed to investigate role circ-SFMBT2 and provide a potential mechanism explain its function. The expression circ-SFMBT2, miR-885-3p chromodomain-helicase-DNA-binding protein 7 (CHD7) mRNA was determined by quantitative real-time PCR (qRT-PCR), level CHD7 western blot. To function vitro, effects on cell viability, colony formation,...
Approximately 80% of patients with advanced bladder cancer do not respond to immune checkpoint inhibitor (ICI) immunotherapy. Therefore, there is an urgent unmet need develop clinically relevant preclinical models so that factors governing immunotherapy responses can be studied in immunocompetent mice. We developed a line mouse triple knockout (TKO: Trp53, Pten, Rb1) urothelial carcinoma organoids transplanted into These tumors recapitulate the molecular phenotypes and heterogeneous observed...
Abstract Background: Androgen receptor signaling is crucial to prostate cancer aggressiveness. Members of the solute carrier family organic anion transporting peptides (SLCO) are potential regulators androgen availability in tissue. It remains unknown whether genetic variations SLCOs contribute differences aggressiveness African Americans (AA) and European (EA). Methods: SNPs 11 SLCO members were selected, with addition 139 potentially functional 128 ancestry informative markers. A total...
Dietary isothiocyanate (ITC) exposure from cruciferous vegetable (CV) intake may improve non-muscle invasive bladder cancer (NMIBC) prognosis. This study aims to investigate whether genetic variations in key ITC-metabolizing/functioning genes modify the associations between dietary ITC and NMIBC prognosis outcomes.
No AccessJournal of UrologyTranslational Research Article7 Jun 2024The Influence Dietary Isothiocyanates on the Effectiveness Mitomycin C and Bacillus Calmette-Guérin in Treating Nonmuscle-Invasive Bladder CancerThis article is commented by following:Editorial CommentEditorial Comment Marilyn L. Kwan, Zinian Wang, Reina Haque, Valerie S. Lee, Janise M. Roh, Isaac J. Ergas, Kimberly Cannavale, Rachel Pratt, Maciej Goniewicz, Ronald K. Loo, David Aaronson, Charles P. Quesenberry, Yuesheng...
Abstract Bladder cancer is primarily diagnosed as non–muscle-invasive bladder (NMIBC), with high recurrence and progression rates. Environmental occupational exposures to carcinogens are well-known risk factors for developing cancer, yet their effects on prognosis remain unknown. In the Be-Well Study, a population-based prospective cohort study of 1472 Kaiser Permanente patients newly NMIBC in California from 2015 2019, we examined history environmental relation tumor stage grade at initial...
Objective:To investigate surgical treatment of carotid artery diseases in neck tumor surgery. Methods:A retrospective analysis the clinical data on was conducted five cases surgeries treated at Department Surgical Oncology, First Peoples Hospital Lanzhou from March 2010 to May 2020. methods, including resection and ligation, tumor-involved vascular reconstruction, peeling rupture repairing were used, respectively. Results:Five successfully operated on. One case ligation followed by...