A5044701151- Japanese History and Culture
- Hong Kong and Taiwan Politics
- Asian Culture and Media Studies
- Toxoplasma gondii Research Studies
- Chinese history and philosophy
- Translation Studies and Practices
- Antimicrobial Resistance in Staphylococcus
- Simulation and Modeling Applications
- Bacterial biofilms and quorum sensing
- Evaluation and Optimization Models
- Advanced Algorithms and Applications
- Mycobacterium research and diagnosis
- Philippine History and Culture
- Hepatitis B Virus Studies
- Antimicrobial Peptides and Activities
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Hepatitis C virus research
- Industrial Technology and Control Systems
- Environmental Quality and Pollution
- Tuberculosis Research and Epidemiology
- Power Systems and Technologies
- Antibiotic Resistance in Bacteria
- Long-Term Effects of COVID-19
- Education and Work Dynamics
Shenzhen University
2023-2025
ShenZhen People’s Hospital
2025
Union Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
University of Electronic Science and Technology of China
2024
Southwest University
2023
First Hospital of Lanzhou University
2004-2023
Lanzhou University
2004-2023
Shenzhen University Health Science Center
2022
Nanfang Hospital
2014-2021
Abstract Understanding the mechanism that leads to immune dysfunction in severe coronavirus disease 2019 (COVID-19) is crucial for development of effective treatment. Here, using single-cell RNA sequencing, we characterized peripheral blood mononuclear cells (PBMCs) from uninfected controls and COVID-19 patients paired broncho-alveolar lavage fluid (BALF). We found a close association decreased dendritic (DCs) increased monocytes resembling myeloid-derived suppressor (MDSCs), which...
The rapid proliferation of multidrug-resistant (MDR) bacterial pathogens poses a serious threat to healthcare worldwide. Carbapenem-resistant (CR) Enterobacteriaceae, which have near-universal resistance available antimicrobials, represent particularly concerning issue. Herein, we report the identification AMXT-1501, polyamine transport system inhibitor with antibacterial activity against Gram-positive and -negative MDR bacteria. We observed minimum inhibitory concentration (MIC)50/MIC90...
This study aims to evaluate the in vitro antibacterial and anti-biofilm activities of licochalcone A on Enterococcus faecalis investigate possible target genes E. faecalis. found that had against faecalis, with MIC50 MIC90 were 25 μM. Licochalcone (at 4 × MIC) indicated a rapid bactericidal effect planktonic cells, killed more cells least 3-log10 cfu/ml) than vancomycin, linezolid, or ampicillin at 2, 4, 6 h time-killing test. 10 significantly reduced production persister 2-log10 24, 48, 72,...
Toxoplasma gondii is one of the most important apicomplexan parasites and infects one-third human population worldwide. Transformation between tachyzoite bradyzoite stages in intermediate host central to chronic infection life-long risk. There have been some transcriptome studies on T. gondii; however, we are still early our understanding kinds levels gene expression that occur during conversion stages. We used high-throughput RNA-sequencing data assemble transcripts using genome-based de...
Infections caused by Gram-positive bacteria pose a serious threat to global public health. Drug resistance, dormant persister cells, and biofilm formation are the key challenges affecting efficacy of antibiotics against bacterial infections. In this study, cinacalcet exhibited good inhibitory activity multidrug-resistant bacteria, with minimum concentrations (MICs) ranging from 3.13 μg/mL 25 μg/mL. Cinacalcet displayed more rapid stronger bactericidal planktonic cells Staphylococcus aureus...
Abstract Understanding the mechanism that leads to immune dysfunction induced by SARS-CoV2 virus is crucial develop treatment for severe COVID-19. Here, using single cell RNA-seq, we characterized peripheral blood mononuclear cells (PBMC) from uninfected controls and COVID-19 patients, in paired broncho-alveolar lavage fluid (BALF). We found a close association of decreased dendritic (DC) increased monocytes resembling myeloid-derived suppressor (MDSC) which correlated with lymphopenia...
Enterococcus faecalis infections pose a significant clinical challenge due to their multidrug resistance and propensity for biofilm formation. Exploring alternative treatment options, such as repurposing existing drugs, is crucial in addressing this issue. This study investigates the antibacterial activity of candesartan cilexetil against E. elucidates its mechanism action. Candesartan exhibited notable both faecium, with minimum inhibitory concentration (MIC) ≤25 μM. Time-kill curves...
Lung nodules are a diagnostic challenge. Current clinical management of lung nodule patients is inefficient and therefore causes patient misclassification, which increases healthcare expenses. However, precise robust classifier to minimize discomfort for costs still lacking. The aim the present protocol evaluate effectiveness using liquid biopsy diagnose compared physician estimates whether can reduce number unnecessary biopsies in benign cases.A prospective cohort 10,560 enrolled at 23...
Chronic obstructive pulmonary disease (COPD) patients with osteoporosis (OP) usually experience more frequent exacerbations, worse quality of life, and heavier economic burden, however, few studies have investigated common molecular mechanisms COPD OP.To explore the relationship between OP through bioinformatics analysis.The miRNA microarray data were retrieved from Gene Expression Database (GEO), differentially expressed microRNAs (DEmiRNAs) screened intersection was obtained. The...
Achieving hepatitis B e antigen (HBeAg) seroconversion is a satisfactory endpoint during antiviral treatment for chronic (CHB). This study aimed to develop and validate novel scoring system predict HBeAg entecavir (ETV) treatment. A total of 526 patients with HBeAg-positive CHB treated ETV at least 1 year were randomly assigned the training validation cohorts. Baseline parameters including virus DNA, surface (HBsAg), core antibody (HBcAb), alanine aminotransferase level quantified. Patients...
To investigate the effects of fine particulate matter with a mean aerodynamic diameter ≤2.5 μm (PM2.5) collected from Lanzhou city on phagocytic function alveolar macrophages (AM) in chronic obstructive pulmonary disease (COPD) mice.Forty male mice were randomly divided into four groups: healthy group, PM2.5 COPD group and group. established by cigarette smoking. (10 mg/kg) air sampler was intratracheally instilled Mice sacrificed after 14 days, isolated. Mean fluorescence intensity (MFI)...
Abstract Liver cirrhosis is associated with defective vaccine responses and increased infections. Dysregulated B cell compartments in cirrhotic patients have been noticed but not well characterized, especially the spleen. Here, we comprehensively investigated perturbations from spleens peripheral blood of patients. We found that liver significantly depleted both switched nonswitched splenic memory cells, which was further confirmed histologically. Bulk RNA-seq revealed significant metabolic...
Both in academic and industrial research, building a green energy-saving network has become hot topic.Combined with hardware division adaptive algorithm, this paper proposes an frequency control mechanism based on traffic to reduce power consumption.By calculating real-time traffic, the device can adjust its operating frequency.On premise of maintaining performance, could consumption significantly.Besides, been verified realized NetFPGA Reference Router.Experimental data show that under...
Synthesizing controllable, photo-realistic images and videos is one of the fundamental goals computer graphics. Neural rendering a rapidly emerging field in image synthesis that allows compact representation scenes, by utilizing neural networks, can be learned from existing observations. Radiance Fields (NeRF) implement an effective combination graphics component Volume rendering. It achieves first photo-level view effect using implicit representation. Unlike previous approaches, NeRF...
The rise of antibiotic-resistant Gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA), presents a significant challenge in clinical settings. There is critical need for new antibacterial agents to combat these resistant strains. Our study reveals that the uricosuric drug Benzbromarone (Benz) exhibits potent activity against with minimum inhibitory concentrations (MICs) ranging from 8 32 μg/mL and bactericidal (MBCs) 128 isolates S. aureus, epidermidis,...
Abstract Multi-drug-resistant Staphylococcus aureus infections necessitate novel antibiotic development. D-3263, a transient receptor potential melastatin member 8 (TRPM8) agonist, has antineoplastic properties. Here, we reported the antibacterial and antibiofilm activities of D-3263. Minimum inhibitory concentrations (MICs) against S. , Enterococcus faecalis E. faecium were ≤ 50 µM. D-3263 exhibited bactericidal effects clinical methicillin-resistant (MRSA) strains at 4× MIC. Subinhibitory...