A5082519209- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Mobile Health and mHealth Applications
- Fetal and Pediatric Neurological Disorders
- Congenital Heart Disease Studies
- Vaccine Coverage and Hesitancy
- Ectopic Pregnancy Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Child Development and Digital Technology
- Influenza Virus Research Studies
- Digital Mental Health Interventions
- Electronic Health Records Systems
- Medical and Agricultural Research Studies
- Congenital Anomalies and Fetal Surgery
- Viral gastroenteritis research and epidemiology
- Pregnancy and preeclampsia studies
- Health Literacy and Information Accessibility
- Smoking Behavior and Cessation
- Esophageal and GI Pathology
- Healthcare Policy and Management
- Infectious Aortic and Vascular Conditions
- Genetic Syndromes and Imprinting
- Vascular Malformations Diagnosis and Treatment
- Autism Spectrum Disorder Research
- Congenital limb and hand anomalies
Children's Hospital of Philadelphia
2020-2024
Fetal Medicine Foundation
2017
Research Centre for Medical Genetics
2010
University of Cambridge
2009
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2006-2007
Abstract Objective To investigate the potential value of maternal serum matrix metalloproteinase‐9 (MMP‐9) in first‐trimester screening for preeclampsia and spontaneous early preterm delivery. Methods The concentrations MMP‐9, tumour necrosis factor soluble receptor‐1 (TNF‐R1), pregnancy‐associated plasma protein‐A (PAPP‐A) uterine artery pulsatility index (UA‐PI) were measured at 11 +0 − 13 +6 weeks cases ( n = 128), gestational hypertension 88), small age 296), delivery 57) controls 569)....
Helping parents quit smoking is a public health priority. However, are rarely, if ever, offered tobacco use treatment through pediatric settings. Clinical decision support (CDS) systems developed for the workflows of primary care may consistent screening, treatment, and referral.This study aimed to develop CDS system by using human-centered design (HCD) that identifies who smoke, provides motivational messages (informed behavioral science), supports delivery evidence-based treatment.Our...
To receive adequate protection against influenza, some children 6 months through 8 y old need two doses of influenza vaccine in a given season. Currently, only half those receiving the first dose second. Our objective was to assess hesitancy and disease knowledge, attitudes, beliefs among caregivers who received their needed doses. As part national-randomized control trial second text-message reminders (2017–2018 season), telephone survey collected caregiver index child demographic...
Among children requiring 2 influenza doses in a given season, second dose receipt nearly halves the odds of influenza. Nationally, many do not receive both needed doses. This study sought to compare effectiveness text message reminders with embedded interactive educational information versus usual care on and timeliness vaccine.This trial took place over 2017 2018 2019 seasons among 50 pediatric primary offices across 24 states primarily from American Academy Pediatrics' Pediatric Research...
Abstract Background Research is needed to identify how clinical decision support (CDS) systems can communication about and engagement with tobacco use treatment in pediatric settings for parents who smoke. We developed a CDS system that identifies smoke, delivers motivational messages start treatment, connects supports pediatrician–parent discussion. Objective The objective of this study assess the performance practice, including receipt acceptance rates. Methods was evaluated at one large...
Introduction. Management of multiple pregnancy complicated by twin-to-twin transfusion syndrome (TTTS) is one the most difficult parts contemporary obstetrics. This develops only in presence anastomoses common placenta monochorionic twins. Without intrauterine correction severe TTTS 80-100% cases or both twins die utero.
 The aim this study to define signs that can help differentiation low high risk group needs be managed centers secondary level care. We investigated 115 twin...
In monochorionic twins there exist some specific complications as twin-to-twin transfusion syndrome and selective growth restriction that could have common features. Also in case of non-immune hydrops one the fetuses it mimic clinical features severe transfusion. this article we describe three cases with different conditions discuss best way to differentiate between these diagnoses.
The aim of this study was to assess the diagnostic value 4-chamber view, 3-vessel and trachea view using high definition power flow Doppler during 11–13 weeks' scan. We conducted a prospective observational in which we check calculated time needed obtain both views displayed at ultrasound image saved beginning end heart assessment. A total 9500 patients were included study. median maternal age 29 years. Crown–rump length 67 mm (range, 45–84 mm). Overall, there 64 cases with congenital...
The aim of the study was to evaluate clinical usefulness two-dimensional B-flow imaging in visualising fetal cardiac blood flow during 11–13 weeks scan. We examined 70 normal singleton fetuses between 11 and 13 + 6 gestation, using VOLUSON E8 Expert ultrasound device with transabdominal 3D/4D transducer. After 4-chamber view 3-vessels trachea 2D mode we applied mode. defined ventricular inflow patterns V sign high definition power Doppler. calculated time needed obtain assess both views HD...
Mobile health (mHealth) is quickly expanding as a method of promotion, but some interventions may not be familiar or comfortable for potential users. SMS text messaging has been investigated low-cost, accessible way to provide vaccine reminders. Most (97%) US adults own cellphone and those most use messaging. However, understanding patterns message plan type in diverse primary care populations needs more investigation.We sought survey examine baseline data among families willing accept...
To assess whether the intertwin discrepancy in crown–rump length (CRL) between two twins at 11+0 to 13+6 weeks of gestation, is predictive poor pregnancy outcome IFV with known date embryo transfer and gestational age (GA). This was a retrospective analysis data collected prospectively over 2 years. Women dichorionic twin after IVF were scanned pregnancy. monochorionic excluded from study because CRL those could be sign early TTTS. The ratio fetuses calculated. CRL-based GA actual compared....
We present a case of prenatal diagnosis trisomy 18 in fetus with diastematomyelia. This diastematomyelia diagnosed at 16 weeks 3 days gestation. The patient was 27-year-old G2P1 who conceived naturally. First ultrasound scan done 11–14 screening and biochemical test for PAPP-F beta-HCG missed. During the examination, we discovered an additional bony structures arising from vertebrae level T10-T11. There some widening spinal canal as well. no sign spina bifida. Another findings were bilateral...
The twin-to-twin transfusion syndrome and twin reversed arterial perfusion are a serious complication of monochorionic pregnancies. Partly as result an inadequate understanding the pathophysiology syndromes, there is lack consensus in clinical management. We sought to review available information on etiology both identify parameters that contribute severity propose rational management plan based pathophysiology, presentation efficacy therapies.
Text messages can be an effective and low-cost mechanism for patient reminders; however, they are yet to consistently integrated into pediatric primary care.
The purpose of this study is to analyse the natural history isolated choroid plexus cysts (CPC) and assess postnatal outcomes in fetuses with prenatal finding. A retrospective review ultrasound records CPC known outcome was performed. Data stratified according maternal age, gestational fetal gender localization cysts. 462 cases were identified within 7 years (2001–2007). Gestational age at time diagnosis varied from 10 29 weeks (mean 19 + 3 weeks). Isolated slightly more common among male...
The purpose of this study is to analyse prenatal sonographic findings and assess postnatal outcomes in fetuses with vein Galen malformation. A retrospective review the ultrasound postnatally confirmed malformation was performed. Four cases were identified within 10 years (2000–2009) all on MRI postmortem study. Gestational age at time diagnosis varied from 24 35 + 1 weeks. Three males one female. In size aneurism remained unchanged during follow-up (14*10 mm, 12*12 25*15 mm 75*30...
To estimate the effectiveness of combined ultrasound and biochemical screening in first second trimesters pregnancy. Assessment fetal chromosomal diseases risk based on maternal age, concentration PAPP-A, free β-hCG, value nuchal translucency (NT) presence/absence nasal bone trimester. In trimester we studied AFP, hCG detailed US for protocol. We used scanners Aloka SSD-2000 Medison SA-8000 Live to study more than 3000 fetuses at 10–13 18–24 weeks singleton Since 2003 first-trimester markers...
To assess the performance of first trimester ultrasound in identifying isolated major congenital heart defects (CHD) fetuses with normal anatomy and nuchal translucency (NT). This was a retrospective two-centre study 15778 pregnant women examined at 11 to 13+6 gestational weeks. Women were using 4-chambers 3-vessels views fetal both 2D mode High Definition (HD) Power Flow Doppler mode. A total patients included study. The median maternal age 29 years. Crown–rump length 67 mm (range, 45-84...
To assess the potential of first trimester sonography in detection congenital heart defects (CHD) using 4 chamber view only and 3 vessel addition to heart. This was a retrospective two-centre study 15778 pregnant women examined at 11 13+6 gestational weeks. Women were views fetal both 2D mode High Definition (HD) Power Flow Doppler mode. A total patients included study. The median maternal age 29 years. Crown–rump length 67 mm (range, 45-84 mm). Overall, there 201 cases with CHD. Only major...
Congenital abdominal aortic aneurysms (AAA) are rare in newborns and infants. The etiology of congenital AAA remains unknown. We report prenatal ultrasound postnatal computer tomography (CT) findings outcome a case AAA. Supporting information can be found the online version this abstract Please note: publisher is not responsible for content or functionality any supporting supplied by authors. Any queries (other than missing content) should directed to corresponding author article.