A5111884722- Amyotrophic Lateral Sclerosis Research
- Neuroblastoma Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- CNS Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Thyroid Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Neurological diseases and metabolism
- Neurogenetic and Muscular Disorders Research
- Prion Diseases and Protein Misfolding
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Intensive Care Unit Cognitive Disorders
- Lipid metabolism and biosynthesis
- Temporomandibular Joint Disorders
- Hereditary Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
- Proteoglycans and glycosaminoglycans research
- 14-3-3 protein interactions
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Histone Deacetylase Inhibitors Research
- Folate and B Vitamins Research
Hangzhou Hospital of Traditional Chinese Medicine
2025
First Affiliated Hospital of Jiangxi Medical College
2022-2024
Beijing Sanbo Brain Hospital
2022-2024
Jiangxi Provincial People's Hospital
2020-2024
Capital Medical University
2022-2024
Central South University
2023-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Creative Commons
2023
Nanchang University
2020-2022
Sichuan University
2021
BackgroundNeuroblastomas are characterized by chromosomal alterations with biological and clinical significance. We analyzed paired blood primary tumor samples from 22 children high-risk neuroblastoma for loss of heterozygosity (LOH) DNA copy number change using the Affymetrix 10K single nucleotide polymorphism (SNP) array.FindingsMultiple areas LOH gain were seen. The most commonly observed area was on chromosome arm 11q (15/22 samples; 68%). Chromosome highly associated occurrence 3p LOH:...
Hydrogen sulfide (H(2)S) is considered as the third gasotransmitter after nitric oxide and carbon monoxide. This gas molecule participates in regulation of renal function. Diabetic nephropathy (DN) one major chronic complications diabetes. The present study aimed to explore changes H(2)S metabolism early stage DN effects on cultured rat glomerular mesangial cells (MCs).Cultured MCs streptozotocin (STZ)-induced diabetic rats were used this study. Expression levels cystathionine γ-lyase (CSE),...
Abstract Amyotrophic lateral sclerosis (ALS) involves the abnormal posttranslational modifications and fibrillization of copper, zinc superoxide dismutase (SOD1) TDP-43. However, how SOD1-catalyzed reaction product hydrogen peroxide affects amyloid formation SOD1 TDP-43 remains elusory. 90% ALS cases are sporadic remaining familial ALS. In this paper, we demonstrate that H 2 O at pathological concentrations triggers wild-type both in vitro SH-SY5Y cells. Using an anti-dimedone antibody...
Osteonecrosis of the femoral head (ONFH) is a debilitating condition characterized by death bone cells in hip joint, resulting profound disability. This has significant global prevalence. Glucocorticoid (GC)-induced apoptosis serves as crucial cellular mechanism underlying ONFH. The protein kinase C zeta (PKCζ) and c-Jun N-terminal (JNK)/c-Jun cascades have been implicated progression ONFH, yet their interrelationship contributions to disease development remain unclear. objective this study...
Background: Nicotinamide adenine dinucleotide (NAD+) metabolism has drawn more attention on neurodegeneration research; however, the role in Amyotrophic Lateral Sclerosis (ALS) remains to be fully elucidated. Here, purpose of this study was investigate whether circulating NAD+ metabolic-related gene signature could identified as a reliable biomarker for ALS survival. Methods: A retrospective analysis whole blood transcriptional profiles and clinical characteristics 454 patients conducted...
Stromal contamination is one of the major confounding factors in analysis solid tumor samples by single nucleotide polymorphism (SNP) arrays. As we propose to use genome-wide SNP microarray as a diagnostic platform for neuroblastoma, sensitivity, specificity, and accuracy these studies must be optimized. To investigate effects stromal contamination, derived early-passage cell lines from nine primary tumors compared their genomic signature with that using 100K The average concordance between...
The present study aimed to investigate the effect of microRNA-150 (miRNA/miR-150) in osteosarcoma (OS) cell invasion and metastasis by regulation Ezrin. To compare differences expression miR-150 Ezrin, models OS were established exogenous transfection on basis different levels miR-150. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used estimate these levels. Ezrin detected western blot assay. Methylthiazolyldiphenyl-tetrazolium bromide assay performed determine...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, and its candidate biomarkers have not yet been fully elucidated in previous studies. Therefore, with the present study, we aim to define verify effective of ALS by bioinformatics. Here, employed differentially expressed gene (DEG) analysis, weighted co-expression network analysis (WGCNA), enrichment immune infiltration protein–protein interaction (PPI) identify ALS. To validate biomarkers, isolated lumbar spinal cord...
The development of amyotrophic lateral sclerosis (ALS) may be related to the abnormal alterations multiple proteins. Our previous study revealed that expression phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4) was decreased in ALS. However, role PIK3R4 ALS pathogenesis remains unknown. This first find transfection PC12 cells with small interfering RNA against gene significantly levels and autophagy-related proteins p62 LC3. Additionally, vivo experiments protein extensively expressed...
Pain was considered a common and neglected symptom in amyotrophic lateral sclerosis (ALS) had substantial impact on the quality of life ALS patients their caregivers. However, pain mainly evaluated from perspective nociceptive pain; only three studies referred to neuropathic ALS, there has been yet no study considering characteristics China. Therefore, purpose our determine (nociceptive pain) by different types questionnaires. The correlation between clinical parameters also evaluated....
<title>Abstract</title> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, the accurate pathogenesis of ALS hasn’t been found up to now. The previous studied results revealed that abnormal alterations some non-motor neurons (MN) were one potential MN death in ALS. Therefore, we altered features 5-hydroxytryptamine (5-HT) distribution and expression spinal cord brainstem both Tg(SOD1*G93A)1Gur (TG) wild-type (WT) mice through fluorescent immunohistochemistry Western...
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Abstract Primary central nervous system lymphoma (PCNSL) are rare extranodal large B-cell lymphomas. There no standard-of-care treatment options for patients with relapsed and refractory PCNSL the overall prognosis is poor. We conducted a phase 2 clinical trial to evaluate efficacy adverse events of PD-1 antibody camrelizumab in relapsed/refractory PCNSL. Enrolled received 200mg intravenously every weeks. The primary endpoint was response rate (ORR). Here we present results 20 who treated...
JOURNAL/nrgr/04.03/01300535-202419110-00031/figure1/v/2024-03-08T184507Z/r/image-tiff Amyotrophic lateral sclerosis is a neurodegenerative disease, and the molecular mechanism underlying its pathology remains poorly understood. However, inflammation known to play an important role in development of this condition. To identify driver genes that affect inflammatory response amyotrophic sclerosis, as well potential treatment targets, it crucial analyze brain tissue samples from patients with...
Rationale and objectives Considering the great insufficiency in survival prediction therapy of amyotrophic lateral sclerosis (ALS), it is fundamental to determine an accurate for both clinical practices design treatment trials. Therefore, there a need more biomarkers that can be used identify subtype ALS which carries high risk progression guide further treatment. Methods The transcriptome profiles parameters total 561 patients this study were analyzed retrospectively by analysis four public...
Making a confident diagnosis is complex task for specific form of interstitial lung disease and providing appropriate management in an attempt to achieve normalization the can put up alarming process clinicians. A set diffuse restrictive diseases incorporate with idiopathic pneumonias, showing inflammation fibrosis interstitium due parenchymal damage. High-resolution computed tomography (HRCT) has magnified diagnostic standpoint stepwise identification classified various patterns evaluation...
Objective Delirium has been reported in all the course of COVID-19, especially aged patient with severe SARS-CoV-2 infection, but there are few studies on these millions patients none-severe omicron infection. To study incidence delirium and its factors hospitalized elderly non-severe Omicron infection，we this single-center observational study. Methods Patients tested positive for infection at hospital were included. We used 3-min diagnostic Confusion Assessment Method diagnosis. collected...
Supplementary Figure 2 from Comparison of Primary Neuroblastoma Tumors and Derivative Early-Passage Cell Lines Using Genome-Wide Single Nucleotide Polymorphism Array Analysis