A5020303756- Food Allergy and Anaphylaxis Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Drug-Induced Adverse Reactions
- Long-Term Effects of COVID-19
- Contact Dermatitis and Allergies
- Exercise and Physiological Responses
- Allergic Rhinitis and Sensitization
- Intramuscular injections and effects
- Cardiomyopathy and Myosin Studies
- Electron and X-Ray Spectroscopy Techniques
- Dermatology and Skin Diseases
- Cellular Mechanics and Interactions
- Asthma and respiratory diseases
- Advanced Electron Microscopy Techniques and Applications
- Advanced X-ray Imaging Techniques
- Ocular Diseases and Behçet’s Syndrome
- Microtubule and mitosis dynamics
- Adrenal Hormones and Disorders
- Mobile Health and mHealth Applications
- thermodynamics and calorimetric analyses
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Systemic Lupus Erythematosus Research
Humboldt-Universität zu Berlin
2023-2025
Charité - Universitätsmedizin Berlin
2023-2025
Freie Universität Berlin
2023-2025
University of Pennsylvania
2024
Hospital for Sick Children
2022
California State University, Fullerton
2020
New York Structural Biology Center
2017-2019
University of British Columbia
2016-2018
Vanderbilt University
2018
AbbVie (United States)
2017
The Epipen® Jr and Allerject® 0.15 mg are currently the most commonly prescribed epinephrine auto-injectors (EAIs) for management of anaphylaxis in pediatric patients North America Canada. To ensure rapid absorption, it should be administered intramuscularly into anterolateral aspect thigh. We examined whether 12.7-mm needle length is adequate delivering who weighed <15 kg.Consecutive with food allergy weighing kg required an EAI were included. Ultrasounds mid-anterolateral thigh performed...
Epinephrine auto-injectors are the standard first aid treatment for anaphylaxis. Intramuscular delivery into anterolateral aspect of thigh is recommended optimal onset action epinephrine. The most frequently prescribed auto-injector in North America and Canada EpiPen®, which has a needle length 15.2 mm. Currently, it unknown whether this adequate intramuscular epinephrine adult patients at risk One hundred consecutive with confirmed food allergy requiring an were recruited. Skin to muscle...
There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). SARS-CoV-2 has now become the main trigger ME/CFS. We have already conducted two small proof-of-concept studies on IgG depletion by immunoadsorption (IA) ME/CFS, which showed efficacy most patients. This observational study aims to evaluate of IA patients with post-COVID-19 The primary objective was assess improvement functional ability. Due urgency finding...
Background/Objectives: According to the World Health Organization (WHO) and Centers for Disease Control Prevention (CDC), an estimated 3–6% of people suffer from post-COVID condition or syndrome (PCS). A subset meets diagnostic criteria myalgic encephalomyelitis/chronic fatigue (ME/CFS). Studies have reported that SARS-CoV-2 proteins RNA can persist after acute infection in serum tissues, but their role PCS is unclear. Methods: Here, spike protein was analyzed 121 patients with predominant...
Food allergy is the most common cause of anaphylaxis in children. Intramuscular delivery epinephrine auto-injectors (EAI) standard care for treatment anaphylaxis. We examined if children and adolescents at risk weighing 15–30 kg >30 would receive into intramuscular space with currently available EAI North America Europe. The distance from skin to muscle (STMD) bone (STBD) on mid third anterolateral area right thigh was measured by ultrasound applying either high pressure (max) or slight...
Background: Post-COVID syndrome (PCS) encompasses a diverse array of symptoms persisting beyond 3 months after acute SARS-CoV-2 infection, with mental as well physical fatigue being the most frequent manifestations. Methods: In 144 female patients PCS, hand grip strength (HGS) parameters were assessed an objective measure muscle fatigue, 78 meeting Canadian Consensus Criteria for postinfectious myalgic encephalomyelitis/chronic (ME/CFS). The severity disability and key was evaluated using...
Post-COVID Syndrome (PCS) refers to a diverse array of symptoms that persist beyond 3 months the acute phase SARS-CoV-2 infection. The most frequent symptom is fatigue, which can manifest both mentally and physically. In this study, handgrip strength (HGS) parameters were determined as an objective measure muscle fatigue fatigability. HGS correlated with other fre-quent among 144 female PCS patients suffering from exertional intolerance, cognitive impairment. Seventy-eight met Canadian...
Allergen-specific subcutaneous immunotherapy is an effective treatment for certain allergic disorders. Ideally, it should be administered into the space in mid-posterolateral upper arm. Injections are commonly given using a standard allergy syringe with needle length of 13 mm. Therefore, there risk intramuscular administration if patients have skin-to-muscle depth <13 mm, which may increase anaphylaxis. The objective this study was to determine whether appropriate receiving...
Fatigue is the most commonly reported and debilitating extraglandular symptom of primary Sjögren′s syndrome (pSS). exertional intolerance are hallmark symptoms myalgic encephalomyelitis/chronic fatigue (ME/CFS). We aimed to characterize further among pSS patients determine whether there a overlap in ME/CFS. In 19 with pSS, we assessed severity disease activity via questionnaires as well Canadian Consensus Criteria (CCC) for Hand grip strength (HGS) levels α1-, α2-, β1-, β2-, M3-...
<ns4:p>This article was migrated. The marked as recommended. Physician advocacy and leadership is increasingly recognized an important part of our social responsibility. Frameworks, such CanMEDS, have set out definitions health for medical education. Despite calls mandatory teaching potential wellness benefits, presently curricula do not usually teach practical skills to learners. There also a demonstrated disconnect between staff resident perceptions advocacy. Our group create innovative...
Background Omalizumab is a humanized antibody utilized for patients with moderate/severe allergic asthma. There an estimated risk of anaphylaxis to omalizumab in 0.1% patients. should be received the subcutaneous tissue mid-posterolateral upper arm. may increased if injections are intramuscularly (IM). In our clinic, given BD EclipseTM Needle, which routinely provided drug and has needle length 16mm. If patient skin muscle depth (STMD) less than 16mm, there being injected IM.
Background Subcutaneous immunotherapy (SIT) injections for aeroallergens are often utilized in patients. SIT should be injected into the subcutaneous space mid-posterolateral upper arm. If given intramuscularly (IM), there may an increased risk of anaphylaxis. In our allergy clinic, is with BD Safety Glide™ Allergy syringes needle length 13mm. There a being IM if patients have skin to muscle depth (STMD) less than Methods Charts were reviewed clinic on where ultrasound left posterolateral...
Background: The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which can be applied the study ON. Objective: objective this was investigate ON abnormalities by means magnetization evaluate their association other structural functional parameters visual pathway...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with 5-year survival rate of only 10%. One hallmark PDAC’s tumor microenvironment dense desmoplasia, due to abnormal accumulation extracellular matrix and proliferative fibroblasts. During tumorigenesis, pancreatic stellate cells (PSCs) obtain myofibroblast-like signatures contribute the fibrotic environment PDAC. Desmoplasia-induced hypovascularity severely limits oxygen nutrient delivery. Our laboratory...
Abstract According to the World Health Organization (WHO) and Centers for Diseases Control Prevention (CDC), currently an estimated 3 – 6 % of people suffer from post-COVID condition or syndrome (PCS). A subset meets diagnostic criteria myalgic encephalomyelitis/chronic fatigue (ME/CFS). Several studies have reported persistence SARS-CoV-2 proteins RNA in serum tissues both recovered individuals PCS patients. In this exploratory study, we investigated whether spike protein is associated with...
Methods This study was performed in a referral allergist’s office Ontario. Prospectively, all patients (<18 years old) with peanut allergy who were tested for specific IgE (PN IgE) also had Vit D measured. All measurements done between December 2010 and May 2011. The measure 25-hydroxy vitamin D. Patients divided into three groups: deficient (less than 25 nmol/L), insufficient (25-75 nmol/L) sufficient (75-250 nmol/L). levels compared to PN IgE, sex, age, body mass index (BMI) other allergies.
Background Epinephrine delivered by an auto-injector to the anterolateral aspect of thigh is standard care for emergency treatment anaphylaxis. For most pediatric patients in Canada, EpipenJr prescribed, which has a needle length 12.7mm. The route epinephrine administration affects its onset action, and intramuscular delivery recommended rapid absorption. If injected subcutaneously, absorption will be slower. Conversely, if it into bone, unpredictable. There are no published clinical studies...
Studies have shown that postpartum weight retention is a key contributor to obesity among women. also resources dedicated loss are scarce. Weight tracking has been found help with management during pregnancy. However, weight-loss tracker (PPWLT) was yet exist. This article describes the creation and initial impressions of PPWLT were collected via focus groups (FG) discussions WIC participants. Methods: Two FG (English Spanish) conducted at clinic in Southern California. All audio-recorded...