A5101419756- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Histone Deacetylase Inhibitors Research
- Lipid Membrane Structure and Behavior
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- Phytochemical and Pharmacological Studies
- Food Quality and Safety Studies
- Pancreatic and Hepatic Oncology Research
- Enhanced Recovery After Surgery
- Protein Tyrosine Phosphatases
- Gastric Cancer Management and Outcomes
- Metal complexes synthesis and properties
- Coronary Interventions and Diagnostics
Vanderbilt University
2023-2024
Third Xiangya Hospital
2024
Central South University
2024
The high potential of siRNAs to silence oncogenic drivers remains largely untapped due the challenges tumor cell delivery. Here, divalent lipid-conjugated are optimized for in situ binding albumin improve pharmacokinetics and Systematic variation siRNA conjugate structure reveals that location linker branching site dictates tendency toward association versus self-assembly, while lipid hydrophobicity reversibility also contribute intracellular lead increases accumulation 12-fold orthotopic...
Abstract Background Combination therapy involving immune checkpoint blockade (ICB) and other drugs is a potential strategy for converting immune-cold tumors into immune-hot to benefit from immunotherapy. To achieve drug synergy, we developed homologous cancer cell membrane vesicle (CM)-coated metal-organic framework (MOF) nanodelivery platform the codelivery of TLR7/8 agonist with an epigenetic inhibitor. Methods A novel biomimetic system (MCM@UN) was constructed by MOF nanoparticles UiO-66...
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due the challenges tumor cell delivery. Here, were optimized
Peripheral artery disease is commonly treated with balloon angioplasty, a procedure involving minimally invasive, transluminal insertion of catheter to the site stenosis, where inflated open blockage, restoring blood flow. However, peripheral angioplasty has high rate restenosis, limiting long-term patency. Therefore, sometimes paired delivery cytotoxic drugs like paclitaxel reduce neointimal tissue formation. We pursue intravascular drug strategies that target underlying cause restenosis -...
siRNA therapeutics have considerable potential as molecularly-targeted in malignant disease, but identification of effective delivery strategies that mediate rapid intracellular while minimizing toxicity has been challenging. Our group recently developed and optimized an conjugate platform termed "siRNA-L