Evan McDermot
A5066345442- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Data-Driven Disease Surveillance
- COVID-19 and Mental Health
- Advanced biosensing and bioanalysis techniques
- Human Mobility and Location-Based Analysis
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Clinical Laboratory Practices and Quality Control
- CRISPR and Genetic Engineering
University of Washington
2020-2025
Brotman Baty Institute
2020-2025
Abstract Many studies have used mobile device location data to model SARS-CoV-2 dynamics, yet relationships between mobility behavior and endemic respiratory pathogens are less understood. We studied the effects of population on transmission 17 viruses in Seattle over a 4-year period, 2018-2022. Before 2020, visits schools daycares, within-city mixing, visitor inflow preceded or coincided with seasonal outbreaks viruses. Pathogen circulation dropped substantially after initiation COVID-19...
The coronavirus disease 2019 (COVID-19) pandemic is dominated by variant viruses; the resulting impact on severity remains unclear. Using a retrospective cohort study, we assessed hospitalization risk following infection with 7 severe acute respiratory syndrome 2 (SARS-CoV-2) variants.Our study includes individuals positive SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) in Washington Disease Reporting System available viral genome data, from 1 December 2020 to 14 January...
Structured Abstract Background The urgent need for massively scaled clinical testing SARS-CoV-2, along with global shortages of critical reagents and supplies, has necessitated development streamlined laboratory protocols. Conventional nucleic acid SARS-CoV-2 involves collection a specimen nasopharyngeal swab in transport medium, extraction, quantitative reverse transcription PCR (RT-qPCR) (1). As across the world, supply chain buckled, rendering materials scarce (2). To address shortages,...
Novel variants continue to emerge in the SARS-CoV-2 pandemic. University testing programs may provide timely epidemiologic and genomic surveillance data inform public health responses. We conducted from September 2021 February 2022 a university population under vaccination indoor mask mandates. A total of 3,048 24,393 individuals tested positive for by RT-PCR; whole genome sequencing identified 209 Delta 1,730 Omicron genomes 1,939 sequenced. Compared Delta, had shorter median serial...
SARS-CoV-2 transmission is largely driven by heterogeneous dynamics at a local scale, leaving health departments to design interventions with limited information. We analyzed genomes sampled between February 2020 and March 2022 jointly epidemiological cell phone mobility data investigate fine scale spatiotemporal in King County, Washington, diverse, metropolitan US county. applied an approximate structured coalescent approach model within North County South alongside the rate of outside...
The urgent need for massively scaled clinical testing SARS-CoV-2, along with global shortages of critical reagents and supplies, has necessitated development streamlined laboratory protocols. Conventional nucleic acid SARS-CoV-2 involves collection a specimen nasopharyngeal swab in transport medium, extraction, quantitative reverse-transcription PCR (RT-qPCR). As across the world, supply chain buckled, rendering materials scarce. To address shortages, we developed SwabExpress, an end-to-end...
Abstract Background The COVID-19 pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed hospitalization risk following infection with seven SARS-CoV-2 variants. Methods Our study includes individuals positive RT-PCR in Washington Disease Reporting System available viral genome data, from December 1, 2020 to January 14, 2022. analysis was restricted cases specimens collected through sentinel...
Institutions of higher education (IHE) have been a focus SARS-CoV-2 transmission studies but there is limited information on how viral diversity and at IHE changed as the pandemic progressed.
Few US studies have reexamined risk factors for SARS-CoV-2 positivity in the context of widespread vaccination and new variants or considered cocirculating endemic viruses, such as rhinovirus.To evaluate how symptoms associated with test changed over course pandemic to compare these rhinovirus positivity.This case-control study used a test-negative design multivariable logistic regression assess associations between self-reported demographic symptom variables 25-month period. The was...
Abstract SARS-CoV-2 transmission is largely driven by heterogeneous dynamics at a local scale, leaving health departments to design interventions with limited information. We analyzed genomes sampled between February 2020 and March 2022 jointly epidemiological cell phone mobility data investigate fine scale spatiotemporal in King County, Washington, diverse, metropolitan US county. applied an approximate structured coalescent approach model within North County South alongside the rate of...
Abstract Many studies have used mobile device location data to model SARS-CoV-2 dynamics, yet relationships between mobility behavior and endemic respiratory pathogens are less understood. We studied the impacts of human on transmission 16 viruses in Seattle over a 4-year period, 2018-2022. Before 2020, school-related foot traffic large-scale population movements preceded seasonal outbreaks viruses. Pathogen circulation dropped substantially after initiation stay-at-home orders March 2020....
The COVID-19 pandemic spurred the development of innovative solutions for specimen collection and molecular detection large-scale community testing. Among these developments is
At-home respiratory specimen collection for pathogen testing enables community sampling. Furthermore, it requires neither a health care worker’s time nor personal protective equipment, and symptomatic individuals can continue to self-isolate. However, questions remain as whether unsupervised upper by in their homes reliably produce specimens that are of high enough quality testing. From October 2019 through May 2020, the Seattle Flu Study (1, 2) greater Coronavirus Assessment Network (SCAN;...
Institutions of higher education (IHEs) have been a focus SARS-CoV-2 transmission studies but there is limited information on how viral diversity and at IHEs changed as the pandemic progressed. Here we analyze 3606 genomes from unique COVID-19 episodes collected public university in Seattle, Washington (WA) September 2020 to 2022. Across study period, found evidence frequent among affiliates with 60% (n=2153) campus specimens genetically identical least one other specimen. Moreover, viruses...
Abstract Unsupervised upper respiratory specimen collection is a key factor in the ability to massively scale SARS-CoV-2 testing. But there concern that unsupervised may produce inferior samples. Across two studies included at-home mid-turbinate collection, ∼1% of participants used wrong end swab. We found molecular detection pathogens and human biomarker were comparable between specimens collected from handle swab those correctly. Older more likely use backwards. Our results suggest errors...
Abstract Novel variants continue to emerge in the SARS-CoV-2 pandemic. University testing programs may provide timely epidemiologic and genomic surveillance data inform public health responses. We conducted from September 2021 February 2022 a university population under vaccination indoor mask mandates. A total of 3,048 24,393 individuals tested positive for by RT-PCR; whole genome sequencing identified 209 Delta 1,730 Omicron genomes 1,939 sequenced. Compared Delta, had shorter median...
ABSTRACT Importance Few US studies have reexamined risk factors for SARS-CoV-2 positivity in the context of widespread vaccination and new variants or considered co-circulating endemic viruses, such as rhinovirus. Objective To understand how symptoms associated with test changed over course pandemic to compare these rhinovirus positivity. Design This test-negative design study used multivariable logistic regression assess associations between self-reported demographic symptom variables a...