A5077759733- Immune cells in cancer
- Congenital heart defects research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Neuroscience of respiration and sleep
- Protein Kinase Regulation and GTPase Signaling
- COVID-19 Clinical Research Studies
- Brain Metastases and Treatment
- SARS-CoV-2 detection and testing
- Ethics and Legal Issues in Pediatric Healthcare
- Ion Transport and Channel Regulation
- Neonatal Respiratory Health Research
- Cardiovascular Syncope and Autonomic Disorders
- Psoriasis: Treatment and Pathogenesis
- Advanced Glycation End Products research
- Atherosclerosis and Cardiovascular Diseases
- Patient Safety and Medication Errors
- Prenatal Screening and Diagnostics
- Management of metastatic bone disease
Altius Institute for Biomedical Sciences
2017-2022
Swedish Medical Center
2020-2022
Loma Linda University
2018
Medical Discovery Partners (United States)
2017
Reproductive Science Center
2016
California Institute for Regenerative Medicine
2015
Shady Grove Fertility Center
2015
Human Genome Sciences (United States)
2015
University of Washington
2011-2014
University of Illinois Urbana-Champaign
2001-2008
The coronavirus disease 2019 (COVID-19) pandemic is dominated by variant viruses; the resulting impact on severity remains unclear. Using a retrospective cohort study, we assessed hospitalization risk following infection with 7 severe acute respiratory syndrome 2 (SARS-CoV-2) variants.Our study includes individuals positive SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) in Washington Disease Reporting System available viral genome data, from 1 December 2020 to 14 January...
The outbreak of novel coronavirus (SARS-CoV-2) that causes the respiratory illness COVID-19 has led to unprecedented efforts at containment due its rapid community spread, associated mortality, and lack immunization treatment. We herein detail a case young patient who suffered life-threatening disease multiorgan failure. His clinical course involved profound decompensation such he required support with venovenous extracorporeal membrane oxygenation (VV-ECMO). He also demonstrated...
Abstract Chronic inflammation appears to play a critical role in type 2 diabetes and its complications. Here we tested the hypothesis that this inflammatory dysregulation affects IL-1β system has functional consequences brain. Diabetic, db/db, nondiabetic, db/+, mice were administered i.p. LPS, potent cytokine inducer, at dose of 100 μg/kg/mouse. db/db mouse innate immune-associated sickness behavior was 14.8, 33, 44.7, 34% greater than db/+ 2, 4, 8, 12 h, respectively. When fixed LPS used...
Abstract Background The COVID-19 pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed hospitalization risk following infection with seven SARS-CoV-2 variants. Methods Our study includes individuals positive RT-PCR in Washington Disease Reporting System available viral genome data, from December 1, 2020 to January 14, 2022. analysis was restricted cases specimens collected through sentinel...
The cytotoxic side effects of anti-neoplastic drugs are increased in patients with either type 1 or 2 diabetes mellitus by a mechanism that is not clearly defined. We report the circulating glucose metabolite, methylglyoxal (MGO), enhances cisplatin-induced apoptosis activating protein kinase Cdelta (PKCdelta). found treatment myeloma cells antioxidant N-acetylcysteine completely blocked cisplatin-dependent intracellular GSH oxidation, reactive oxygen species (ROS) generation,...
Acute hypoxia is experienced in an array of ailments and conditions, including asthma, chronic obstructive pulmonary disease, heart failure, sleep apnea, acute hypotension, blast lung injury. Classically, infection activates the neuroimmune system, causing loss interest social environment. We report that non-infectious stimulus triggers system activation (NSA), environment, recovery from hypoxia-induced NSA impaired a mouse model type 2 diabetes. Importantly, behavioral consequences was...
We have shown previously that hyperinsulinemia inhibits interferon-α-dependent activation of phosphatidylinositol 3-kinase (PI3-kinase) through mammalian target rapamycin (mTOR)-induced serine phosphorylation insulin receptor substrate (IRS)-1. Here we report chronic and high glucose synergistically inhibit interleukin (IL)-4-dependent PI3-kinase in macrophages via the mTOR pathway. Resident peritoneal (PerMΦs) from diabetic (db/db) mice showed a 44% reduction IRS-2-associated activity...
There was a greater than 50% decline in central nervous system (CNS) drug discovery and development programs by major pharmaceutical companies from 2009 to 2014. This paralleled rise the number of university led centers, many CNS area, growth public–private partnerships. Diverse operating models have emerged as academic centers adapt this changing ecosystem.
CHF1/Hey2 is a Notch-responsive basic helix–loop-helix transcription factor involved in cardiac development. Common variants Hey2 are associated with Brugada syndrome. We hypothesized that absence of would result abnormal cellular electrical activity, altered conduction system (CCS) development, and increased arrhythmogenesis. isolated neonatal CHF/Hey2-knockout (KO) myocytes measured action potentials ion channel subunit gene expression. also crossed myocardial-specific CHF1/Hey2-KO mice...
Generating cardiomyocytes from embryonic stem cells is an important technique for understanding cardiovascular development, the origins of diseases and also providing potential reagents cardiac repair. Numerous methods have been published but often are technically challenging, complex, not easily adapted to assessment specific gene contributions myocyte differentiation. Here we report development optimized protocol induce differentiation mouse myocytes that simplified genetic studies....
The purpose of this study was to compare the incidence anterior capsular contraction syndrome (ACCS) in cataract patients after implantation with one two most commonly used hydrophobic acrylic lenses.This included from Loma Linda University, Linda, CA, USA.This is a retrospective chart review.In study, 1,047 eyes 811 and without known ACCS risk factors who underwent successful phacoemulsification intraocular lens (IOL) were included. Eyes that sustained intraoperative tears postoperative...
Type 2 diabetes (T2D) is associated with accelerated atherosclerosis, which accounts for approximately 75% of all diabetes-related deaths. Here we investigate the link between and macrophage cholesteryl ester accumulation. When diabetic (db/db) mice are given intraperitoneally (IP), peritoneal macrophages (PerMPhis) recovered from these animals showed a 58% increase in intracellular accumulation over PerMPhis heterozygote control (db/+) mice. Notably, PerMPhi fluid-phase endocytosis large...
Macrophages are capable of assuming numerous phenotypes in order to adapt endogenous and exogenous challenges but many the factors that regulate this process still unknown. We report Ca2+/calmodulin-dependent kinase α (CaMKKα) is expressed human monocytic cells demonstrate its inhibition blocks type-II cell activation promotes classical activation. Affinity chromatography with paramagnetic beads isolated an approximately 50 kDa protein from nuclear lysates U937 activated...
1. The oxygen uptake of renal cortex slices 29 control rats and 42 animals in which the nephrotic syndrome had been induced by intravenous injection nephrotoxic sera was studied. 2. In Krebs-Ringer solution, without added substrates, average did not differ from that controls. 3. Addition glucose or fructose resulted invariably an increase slices. No consistent after addition these two hexoses noted when kidney were obtained rats. 4. produced lactate, succinate, glutamate, acetoacetate...
Abstract We have shown that SurePath when compared to conventional Paps fails increase HSIL detection. In this study, assessment of test performance characteristics for the FocalPoint showed sensitivity was 96% manual screening used as “gold standard.” When cervical biopsy, however, standard” decreased 93%, which same screening. Examination “no further review” cases 4/296 were SIL. To understand better implication an SIL diagnosis, biopsies generated from and compared. Conventional diagnosed...
SOCIETY OF CRITICAL CARE MEDICINE 32ND CONGRESS SAN ANTONIO, TEXAS, USA JANUARY 28-FEBRUARY 2, 2003: ORAL/SANDWICH PRESENTATIONS: Poster Presentation: Ethics and End of Life: PDF Only
SOCIETY OF CRITICAL CARE MEDICINE 32ND CONGRESS SAN ANTONIO, TEXAS, USA JANUARY 28-FEBRUARY 2, 2003: ORAL/SANDWICH PRESENTATIONS: Poster Presentation: Epidemiology Outcomes II: PDF Only
The mouse vaginal assay was modified to study mechanisms of drug action in epithelial cells relation the cell cycle. An evaluation labeling index, mitotic and percent labeled mitoses epithelium used determine site Systemic absorption from also monitored by these same measurements rectal mucosa. Thirty drugs tested; 17 showed kinetic perturbations mucosa four had both (local) (systemic) effects. Thirteen no effect, suggesting inadequate concentration, penetration, duration exposure, or lack...