A5102927018- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ectopic Pregnancy Diagnosis and Management
- Plant Stress Responses and Tolerance
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Chemical Synthesis and Analysis
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Microbial Natural Products and Biosynthesis
Kunming Institute of Botany
2023
University of Chinese Academy of Sciences
2023
Chinese Academy of Sciences
2023
Nanchang University
2020-2021
Second Affiliated Hospital of Nanchang University
2020-2021
National Cancer Institute
2013
Abstract Touch induces marked morphological changes in plants, including reduced rosette diameters and delayed flowering, a process called thigmomorphogenesis. Previous studies have revealed that thigmomorphogenesis Arabidopsis (Arabidopsis thaliana) results from touch-induced accumulation of jasmonic acid (JA) GIBBERELLIN 2-OXIDASE7 (GA2ox7) transcripts, which encode gibberellin (GA) catabolism enzyme, leading to levels active GAs. However, the mechanisms underlying remain uncharacterized....
Bufalin (BF) exhibited antiproliferation and antimigration effects on human A549 lung cancer cells. To search its target-related proteins, protein expression profiles of BF-treated control cells were compared using two quantitative proteomic methods, iTRAQ-based label-free analysis. A total 5428 proteins identified in analysis while 6632 The number common both methods was 4799 proteins. By application 1.20-fold for upregulated 0.83-fold downregulated cutoff values, 273 802 differentially...
Abstract Non-small cell lung cancer (NSCLC) carrying sensitizing epidermal growth factor receptor (EGFR) mutations can initially benefit from erlotinib (EGFR inhibitor) treatment. However, patients invariably develop resistance through secondary EGFR mutations, c-MET amplification, epithelial-mesenchymal transition (EMT), small transformation, PIK3CA mutation and other unknown mechanisms. Here we examined whether Cripto1, which has been shown to induce EMT, could cause resistance. We show...
Objective: This study aims to investigate the etiological and bleeding risk factors of cesarean scar pregnancy (CSP) attempts determine clinical value uterine artery embolization (UAE) combined with curettage, methotrexate (MTX) chemotherapy curettage alone in terminating CSP. Materials methods: A total 154 patients CSP 155 cicatricial uterus termination same period who were hospitalized Department Obstetrics Gynecology, Second Affiliated Hospital Nanchang University from January 2013 March...
Abstract Background: Ovarian cancer (OC) is one of the most common gynecological malignancies and has highest mortality rate worldwide. Therefore, identification novel targets development more effective therapeutic treatments are essential. Methods: We identified genes with somatic copy number alterations (SCNAs) amplification (AMP) according to The Cancer Genome Atlas (TCGA) OC data. performed a meta-analysis five independent datasets from Gene Expression Omnibus (GEO) database. retrieved...
Abstract The tumor suppressor p21 inhibits cell proliferation during the stress response. However, can also directly regulate gene expression by repressing specific transcription factors. Here, we identified p21-regulated miRNAs sequencing small RNAs from HCT116-p21+/+ and HCT116-p21-/- cells. Three abundant clusters, miR-200b-200a-429, miR-200c-141 miR-183-96-182 were down-regulated in p21-depleted HCT116 MCF10A Loss of induced epithelial-mesenchymal transition (EMT) enhanced migration...