A5087217752- Lung Cancer Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cancer Genomics and Diagnostics
- Blood disorders and treatments
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Platelet Disorders and Treatments
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cancer-related cognitive impairment studies
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Urinary and Genital Oncology Studies
- Global Cancer Incidence and Screening
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Bladder and Urothelial Cancer Treatments
- Neuroendocrine Tumor Research Advances
- Pharmacological Effects and Toxicity Studies
- Thyroid Cancer Diagnosis and Treatment
- Genomics and Rare Diseases
University of Kentucky
2018-2024
University of Kentucky HealthCare
2023
Markey Cancer Center
2018-2021
Saint Peter's University Hospital
2020
e18095 Background: The incidence of thyroid cancer is increasing worldwide, especially in high income countries. A large proportion such an increase attributed to the phenomenon over-diagnosis. It occurs when a disease which would have otherwise not caused any symptoms or death diagnosed. In countries where over-diagnosis reported, majority these diagnoses young and middle-aged women (age < 60 years). Developing regions may be immune cancers. We had recently reported that could reason for...
Abstract Monoclonal gammopathy of uncertain significance associated acquired von Willebrand syndrome is a serious bleeding condition driven by immunological clearance factor and has limited treatment options. We present patient who achieved durable remission through eradication the monoclonal paraprotein with clonal directed therapy bortezomib.
Comprehensive genomic profiling (CGP) assay is increasingly used in low-middle-income countries to detect clinically relevant alterations despite its clinical benefits not being well known. Here, we describe the proportion of patients with advanced cancer India who received targeted therapy for an actionable genetic alteration identified on CGP assays.This was a multicenter, retrospective cohort study adult nonhematologic malignancies underwent test. If ≥ 6 months, they were considered have...
5-fluorouracil (5FU) and capecitabine are fluoropyrimidine anti-neoplastic drugs commonly used in the treatment of different types cancer. Hereditary dihydropyrimdine deaminase (DPD), thymidylate synthase mutations drug overdose may lead to life-threatening toxicities. Uridine triacetate (UTA) is an emergency for overdoses early onset, severe or toxicities from fluoropyrimidines. It approved use adults children within 96 h last administration. We present case a 64-year-old male treated with...
e18555 Background: Stage IIIA non-small cell lung cancer (NSCLC) is a heterogeneous disease treated by surgery-based approach or definitive chemoradiation (CRT) and immunotherapy (ICI) consolidation. Studies have shown that black patients in general are diagnosed at advanced stages, less likely to receive ICI, lower overall survival (OS) compared whites. Importantly, ICI was impart similar even better OS among advanced-stage NSCLC patients, Geographical location socioeconomic status also...
Introduction: Obesity has been well recognized as a marker of poor outcome in AP.[1] Nonalcoholic fatty liver disease (NAFLD), diagnosed by abdominal ultrasound (US), is metabolic obesity. The aim this study to evaluate the correlation between NAFLD US with outcomes AP. Although opportunity diagnose there all patients who have an (less often CT abdomen), test currently performed solely biliary system. Methods: In retrospective electronic medical record-based study, pooled data from 2...
Abstract Background Monoclonal gammopathy of uncertain significance (MGUS) associated acquired von Willebrand syndrome (AvWS) is a rare life-threatening bleeding disorder driven by immunologic clearance circulating factor (vWF). Treatments including replacement and intravenous immunoglobulin (IVIG) provide short-term control. Achieving sustained response frequently challenging there remains lack data regarding long-term management MGUS-associated AvWS, specifically plasma cell depleting...
509 Background: Neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with bilateral pelvic lymph node dissection is the current standard of care for MIBC. Pathologic downstaging NAC an important surrogate endpoint and associated overall survival benefit. There have been questions about impact delay in definitive surgery because NAC. The optimal timing from start uncertain. We studied this question using National Cancer Database (2004-2015). Methods: identified patients MIBC...
Incidence and mortality of colorectal cancers (CRC) have decreased among patients older than 65 years but increased younger 65, especially under 50 age. Precision medicine has improved outcomes through targeted therapies based on molecular features, gene expression, other features tumors. Newer risk prediction models like genetic score (G-score) were shown to increase discriminatory accuracy that further refines CRC risk. Non-invasive blood-based tests the mSEPT9 assay potential improve...