A5075446566- Hormonal and reproductive studies
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Estrogen and related hormone effects
- Multiple and Secondary Primary Cancers
- Pituitary Gland Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Glioma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Cancer Treatment and Pharmacology
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Long-Term Effects of COVID-19
- Cardiac Imaging and Diagnostics
Pikeville Medical Center
2021-2025
University of Pikeville
2022-2024
University of Wisconsin–Madison
2024
Siemens Healthcare (United States)
2023
University Hospital Cologne
2023
University of Cologne
2023
University of Kentucky
2017-2022
Appalachian Regional Healthcare
2022
Palmetto Hematology Oncology
2022
Markey Cancer Center
2017-2022
<title>Abstract</title> Colorectal cancer (CRC) is the 2nd leading cause of death in United States (US). Rural Appalachia suffers highest CRC incidence and mortality rates. There are several non-clinical health-related social determinant factors (SDOH) associated with mortality. This study describes novel predictive modeling that uses demographic, clinical, SDOH features from health records data Appalachian community centers to predict 5-year survival. We trained, validated, tested four...
Overall survival advantage of chemotherapy before versus after metastasectomy liver or lung lesion is not clear for colon cancer with synchronous metastasis.Adults 20 years older primary and single organ metastatic disease either in the at diagnosis were identified between 2010 2015 through National Cancer Database (NCDB). Patients categorized into 2 cohorts: pre-operative/peri-operative (neoadjuvant -[NAC]) post-operative (adjuvant [AC]). Survivals factors associated compared groups.A total...
Understanding of the molecular mechanisms prostate cancer has led to development therapeutic strategies targeting androgen receptor (AR). These androgen-receptor signaling inhibitors (ARSI) include synthesis inhibitor- abiraterone and antagonists- enzalutamide, apalutamide, darolutamide. Although these medications provide significant improvement in survival among men with cancer, drug resistance develops nearly all patients time. This could be through androgen-dependent or...
<h3>Importance</h3> Despite the benefit of peptide receptor radionuclide therapy (PRRT) for patients with well-differentiated neuroendocrine tumors (WD NETs), no clinical metric to anticipate from individual has been previously defined. <h3>Objective</h3> To assess whether prognostic ability score (CS) could be validated in an external cohort WD NETs. <h3>Design, Setting, and Participants</h3> This multicenter study's analysis included NETs who were under consideration lutetium-177...
An 80-year-old Caucasian male presented with fever of 3-week duration. Outpatient workup for infectious etiologies was negative and due to persistent fever, he hospitalized further evaluation unknown origin (FUO). Physical examination laboratory studies remained unremarkable; however a follow-up CT scan chest, abdomen, pelvis contrast done rule out malignancy as an underlying cause FUO revealed heterogeneous thyroid gland surrounding hazy changes suggestive thyroiditis. Thyroid function...
Hairy cell leukemia (HCL) is a rare mature B-cell lymphoproliferative disorder and most often presents as classic hairy leukemia. This entity characterized by an indolent course the presence of BRAF V600E mutation. We report case 80-year-old man with history classical who presented fatigue, dizziness, shortness breath, blurring vision, headache. His initial diagnosis was 9 years prior, he received treatments cladribine, pentostatin, rituximab. The workup showed elevated white blood count...
Takotsubo cardiomyopathy (TTC) is a transient systolic dysfunction of the left ventricle which usually seen in elderly women, often following physical or emotional stressful event. Little known about prognostic factors affecting recovery function. Thirty-six patients diagnosed with TTC from January 2006 to 2017 at our hospital were included. Median time ejection fraction (EF) was calculated be 25 days. Early defined as less than equal days (group 1) and late more 2). Demographic clinical...
Studies have reported second malignancies occurring in patients with chronic myeloid leukemia (CML) or lymphoid (CLL). We discuss the case of a 77-year-old man diagnosed CLL who later developed CML. The was managed surveillance after diagnosis for 3 years and treated ibrutinib venetoclax. While on treatment venetoclax 4 months, patient had worsening leukocytosis shown via peripheral flow cytometry fluorescence situ hybridization, presence lineage cells positive BCR-ABL complete disappearance...
5-fluorouracil (5FU) and capecitabine are fluoropyrimidine anti-neoplastic drugs commonly used in the treatment of different types cancer. Hereditary dihydropyrimdine deaminase (DPD), thymidylate synthase mutations drug overdose may lead to life-threatening toxicities. Uridine triacetate (UTA) is an emergency for overdoses early onset, severe or toxicities from fluoropyrimidines. It approved use adults children within 96 h last administration. We present case a 64-year-old male treated with...
Gastrointestinal tract is the most common site of extranodal non-Hodgkin lymphoma (EN-NHL). Most published data have been on gastric NHL with limited studies primary intestinal (PI-NHL) considering rare incidence. We performed epidemiological and survival analysis for PI-NHL from Surveillance, Epidemiology, End Results (SEER) 18 database.A total 9,143 cases age ≥ years were identified SEER database period 2000 - 2015. Totally, 8,568 patients included analysis. Cause-specific (CSS) overall...
A twenty-two-year-old male with no significant past medical history who presented chest pain was found to have ST-segment elevation in leads II, III, aVF, and V4–V6. On subsequent EKGs, patient had new elevations anterolateral dynamic changes. Cardiac catheterization showed acute dissection thrombosis of the distal left main coronary artery leading into ostial anterior descending artery. The cardiac risk factors including hypertension, hyperlipidemia, diabetes, or family early disease....
Immobilization is an uncommon etiology of hypercalcemia. It usually seen in conditions associated with limited movements such as spinal cord injuries, vascular events, or following prolonged hospitalization. Hereby, we present a case young patient who had hospitalization infection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). During her and complicated hospital stay, she developed hypercalcemia secondary to immobilization, which was resistant treatment hydration, calcitonin,...
A 38-year-old female patient with well-controlled type II diabetes mellitus treated canagliflozin underwent ureteral stent placement for obstructive renal calculi. Ten days following ureteroscopy and stenting, she developed fevers blood cultures grew Candida glabrata (C. glabrata). The was successfully an extended course of broad-spectrum antibiotic antifungal agents. clinical presentation candidemia is nearly indistinguishable from bacteremia can result in a delay diagnosis treatment....
An 83-year-old female patient with rheumatoid arthritis and hypertension presented to the emergency department fever chills of 1 day duration. On examination, temperature was 100.9 F, heart rate 111/min she had orthostatic hypotension. Laboratory tests showed elevated blood urea nitrogen white cell count. The underwent treatment for symptomatic urinary tract infection while her leucocytosis resolved, tachycardia persisted. EKG done T inversions in leads II, III, arteriovenous fistula, V2 V3....
Pituitary apoplexy (PA) is a clinical condition characterised by sudden increase in pituitary gland volume secondary to ischaemia and/or necrosis. Most cases occur non-functioning adenoma but can also functioning adenoma. Certain predisposing factors result PA and the use of gonadotropin-releasing hormone (GnRH) agonists for prostate cancer (PCa) one such condition. Once diagnosed, both surgical conservative management has been used treatment PA. We present case man his late 50s who...
A 24-year-old man with no significant medical history was presented to our emergency department 5 days of fever chills, rigors and abdominal pain. He had recently travelled the Southern part India. Physical examination showed a temperature 101.2°F, conjunctival pallor, left upper quadrant tenderness and moderate splenomegaly. Complete blood count revealed haemoglobin: 9.0 g/dL (normal: 12–16 g/dL), white cell count (WBC): 2600/cu mm (normal: 4000–11 000/cumm) platelets: 80 000/cu mm...
Although opiate use can result in various endocrine disorders, isolated adrenocorticotropic hormone (ACTH) deficiency resulting secondary adrenal insufficiency remains uncommon. We present a case of 54-year-old woman with history chronic who presented four-month worsening fatigue and syncopal episodes. Laboratory workup revealed low ACTH baseline cortisol normal levels rest the anterior pituitary hormones. The imaging study did not reveal any abnormality. patient was diagnosed opiate-induced...
Objective: American College of Graduate Medical Education (ACGME) recommends ongoing care 10 patients per resident however its implication is unclear. We hypothesized EMR quality to vary based on patient load and call status. Methods: conducted a double-blind, single-center, retrospective observational study between 2017 2019 investigate the accuracy documentation using Responsible Electronic Documentation (RED) Checklist, validated scoring system. Results: A total 234 independent charts...