A5066135422- Acute Myeloid Leukemia Research
- Telomeres, Telomerase, and Senescence
- Estrogen and related hormone effects
- Virus-based gene therapy research
- Retinoids in leukemia and cellular processes
- CRISPR and Genetic Engineering
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Menopause: Health Impacts and Treatments
- Glycosylation and Glycoproteins Research
- Multiple Myeloma Research and Treatments
- Toxoplasma gondii Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Chromatin Remodeling and Cancer
- Cancer, Hypoxia, and Metabolism
- Streptococcal Infections and Treatments
- Inflammasome and immune disorders
- Bone health and osteoporosis research
- T-cell and Retrovirus Studies
- Diabetes and associated disorders
- Hematopoietic Stem Cell Transplantation
- Diabetes Management and Research
- Advanced biosensing and bioanalysis techniques
- Cytomegalovirus and herpesvirus research
Alzheimer's Association of Israel
2025
Weizmann Institute of Science
2025
Medizinische Hochschule Hannover
2009-2018
Max Delbrück Center
2011-2012
University of Debrecen
2011
Leiden University Medical Center
2011
University of Tübingen
1995-1996
Universität Ulm
1995
Katharinenhospital
1995
Abstract Telomere shortening and chromosomal instability are believed to play an important role in the development of myeloid neoplasia. So far, published data only available on average telomere length myelodysplastic syndromes (MDS) acute leukemia (AML), but not individual chromosomes. We used a new technique, telomere/centromere‐fluorescence situ hybridization (T/C‐FISH), which combines fluorescence R‐banding FISH using probe against repeats measure each chromosome arm 78 patients with...
The Sleeping Beauty (SB) transposase and its newly developed hyperactive variant, SB100X, are of increasing interest for genome modification in experimental models gene therapy. potential cytotoxicity transposases requires careful assessment, considering that residual integration events expression vectors delivered by physicochemical transfection or episomal retroviral may lead to permanent resulting uncontrollable transposition. Comparing retrovirus-based approaches delivery mRNA, DNA...
The Sleeping Beauty (SB) transposase and its newly developed hyperactive variant, SB100X, are of increasing interest for genome modification in experimental models gene therapy. potential cytotoxicity transposases requires careful assessment, considering that residual integration events expression vectors delivered by physicochemical transfection or episomal retroviral may lead to permanent resulting uncontrollable transposition. Comparing retrovirus-based approaches delivery mRNA, DNA...
Abstract Lysine histone acetyltransferase 6 (KAT6A/B) is a MYST family member of acetyltransferases (HATs), known to regulate gene expression by acetylation both and non-histone substrates. KAT6A/B promising cancer drug target, specifically in estrogen receptor positive (ER+) breast cancer, but anti-cancer activity other indications has also been shown, suggesting potential benefit for wider patient populations. Despite antitumor observed clinical trials, KAT6i inhibitors are reported cause...
Serum oestrogen deficiency is one of the main causes osteoporosis in post-menopausal women. In premenopausal women, rare. 13 women with symptomatic coronary heart disease (CHD) and significantly reduced serum levels, bone mineral density, determined by quantitative computed tomography (QCT), was not reduce. these probably risk factor for development CHD. The level that protects from CHD might be different them early loss density. Seven had a history tubal sterilisation. This possible factor,...
Successful treatment of acute radiation syndromes relies on immediate supportive care. In patients with limited hematopoietic recovery potential, hematopoietic stem cell (HSC) transplantation is the only curative treatment option. We propose MSC as an alternative for severely radiation-affected individuals. In vitro differentiation human (hMSC) into progenitors and endothelial cells revealed that changed their morphology gene expression profile, suggesting that investigated...
Die Fr1dolin-Studie untersucht die Durchführbarkeit eines kombinierten Screenings auf präsymptomatischen Typ 1-Diabetes (T1D) und familiäre Hypercholesterinämie (FH) bei Kindern zwischen 2 6 Jahren in Niedersachsen. Eine Vorreiterrolle stellt Fr1da-Studie als T1D-Screening Bayern dar.
Hanke, Hartmut M.D.; Sybille Mick, Al-fred O. Ph.D. Ickrath, Oliver Lange, Kathrin; Bruck, Birgit Vois-ard, Rainer Seeger, Harald Ph.D.; Zwirner, Manfred Both, Anton Haasis, Hombach, Vinzenz M.D. Author Information