A5101657749- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Proteoglycans and glycosaminoglycans research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Treatment of Major Depression
- Pelvic floor disorders treatments
- Cancer, Lipids, and Metabolism
- Kidney Stones and Urolithiasis Treatments
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Renal function and acid-base balance
- Phytochemical Studies and Bioactivities
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Berberine and alkaloids research
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Autophagy in Disease and Therapy
- Intraocular Surgery and Lenses
- Bladder and Urothelial Cancer Treatments
- Synthesis and Biological Activity
- Renal and Vascular Pathologies
First Affiliated Hospital of Jinan University
2020-2023
Castration-resistant prostate cancer (CRPC) inevitably arises after androgen deprivation therapy (ADT). Therefore, there is an urgent need to search for novel treatment strategies CRPC. Polyphyllin I (PPI), one of the steroidal saponins in paris polyphylla, has been shown have anticancer effect. This study investigated role and mechanism PPI CRPC cell ferroptosis.Protein levels GPX4, p-extracellular regulated protein kinases (ERK), ERK, DNMT1, ACSL4 were measured by Western blot. DNMT1 mRNA...
The present study was aimed to observe the effect of berberine (Ber) on epirubicin (EPI)-induced growth inhibition, apoptosis, and cell cycle arrest in T24 bladder cancer cells.The cells were exposed EPI, with or without different concentrations Ber. viability measured by counting Kit-8, apoptosis determined Hoechst 33258 staining expression cleaved caspase-3, caspase-9, Bcl-2, Bax, P53 proteins detected Western blot assay. In addition, production reactive oxygen species (ROS) also...
Metastatic prostate cancer (PCa) remains incurable and fatal. Previous studies have proven that circulating tumor cells (CTCs) Ezrin are involved in PCa progression, metastasis, diagnosis, prognosis. Therefore, we aimed to investigate the roles of CTCs metastasis. The expression was measured by qRT–PCR immunohistochemical staining. migration invasion were evaluated. Additionally, clinical data from patients collected analyze potential PCa. results showed significantly upregulated tissues...
To investigate the clinical and non-clinical characteristics that may affect prognosis of patients with renal collecting duct carcinoma (CDC) to develop an accurate prognostic model for this disease.The 215 CDC were obtained from U.S. National Cancer Institute's surveillance, epidemiology end results database 2004 2016. Univariate Cox proportional hazard Kaplan-Meier analysis used compare impact different factors on overall survival (OS). 10 variables included establish a machine learning...
This study determined the predictive value of CRMP4 promoter methylation in prostate tissues collected by core needle biopsies for a postoperative upgrade Gleason Score (GS) to ≥8 patients with low-risk PCa.A retrospective analysis clinical data was conducted from 631 diagnosed PCa biopsy at multiple centers and then underwent Radical Prostatectomy (RP) 2014-2019. Specimens were detect methylation. The pathologic factors correlated GS analyzed logistic regression. cut-off estimated ROC curve...
The treatment of ketamine-induced bladder contractures remains poorly studied. We therefore evaluated the efficacy cystectasia with a sodium hyaluronate balanced solution in this kind contracture.Eighteen patients presenting contracture between July 2010 and February 2018 were selected analysed. Ketamine was discontinued all patients, who then treated weekly (0.09% solution) 3 times. volume first perfusion twice preoperatively measured capacity, subsequent two perfusions increased by 100 mL...
Objective: Prostate cancer (PCa) is one of the leading causes death by solid tumors in men, and autophagy plays an important role tumor progression treatment. This study was designed to construct evaluate autophagy-related prognosis model PCa with long noncoding RNAs (lncRNAs). Materials Methods: RNA sequencing data clinical features were obtained from The Cancer Genome Atlas (TCGA) prostate adenocarcinoma (PRAD) dataset. These analyzed Pearson correlation Lasso regression enrich for six...