A5033348128- Developmental Biology and Gene Regulation
- Invertebrate Immune Response Mechanisms
- Marine Ecology and Invasive Species
- Neurobiology and Insect Physiology Research
- Ubiquitin and proteasome pathways
- Silk-based biomaterials and applications
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Renal and related cancers
- Animal Behavior and Reproduction
- Immunotherapy and Immune Responses
- Reproductive Biology and Fertility
- RNA Research and Splicing
- Plant Molecular Biology Research
- Neurogenesis and neuroplasticity mechanisms
- 14-3-3 protein interactions
- Hippo pathway signaling and YAP/TAZ
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Marine and coastal plant biology
- Neuroinflammation and Neurodegeneration Mechanisms
National University of Singapore
2009-2013
Temasek Life Sciences Laboratory
2009-2013
Stowers Institute for Medical Research
2005-2011
University of Kansas Medical Center
2005-2011
University of Kansas
2008
Hungarian Academy of Sciences
2007
Eötvös Loránd University
1999-2004
Stem cells, which can self-renew and generate differentiated have been shown to be controlled by surrounding microenvironments or niches in several adult tissues. However, it remains largely unknown what constitutes a functional niche how formation is controlled. In the Drosophila ovary, germline stem cells (GSCs), are adjacent cap two other cell types, maintained niche. this study, we show that Notch signaling controls maintenance of GSC help determine size ovary. Expanded activation causes...
Stem cell self-renewal is controlled by concerted actions of niche signals and intrinsic factors in a variety systems. In the Drosophila ovary, germline stem cells (GSCs) continuously self-renew generate differentiated germ that interact physically with escort (ECs). It has been proposed (ESCs), which directly contact GSCs, ECs to maintain EC population. However, it remains unclear whether differentiation status affects behavior how interaction between regulated. this study, we have found...
Pruning that selectively eliminates unnecessary axons/dendrites is crucial for sculpting the nervous system during development. During Drosophila metamorphosis, dendrite arborization neurons, ddaCs, prune their larval dendrites in response to steroid hormone ecdysone, whereas mushroom body γ neurons specifically eliminate axon branches within dorsal and medial lobes. However, it unknown which E3 ligase directs these two modes of pruning. Here, we identified a conserved SCF ubiquitin plays...